Síntese de inibidores potenciais de hexosaminidases derivados de N-acetilglicosamina e D-glicose
Orbital: The Electronic Journal of Chemistry, 2012 We report herein the synthesis and characterization of N-acetylglucosamine and D-glucose derivates modified at C-1 for evaluation of antifungal activity as potential hexosaminidases inhibitors.
Lucas Lopardi Franco +3 more
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Neurobiology of Disease, 2010 Sandhoff disease is an autosomal recessive lysosomal disorder due to mutations in the β-hexosaminidase β-chain gene, resulting in β-hexosaminidases A (αβ) and B (ββ) deficiency and GM2 ganglioside accumulation in the brain.
Lionel Batista +6 more
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Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. [PDF]
PLoS Genetics, 2014 As newly synthesized glycoproteins move through the secretory pathway, the asparagine-linked glycan (N-glycan) undergoes extensive modifications involving the sequential removal and addition of sugar residues.
Erica E Rosenbaum +3 more
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Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica. [PDF]
PLoS Pathogens, 2012 Lysozymes and hexosaminidases are ubiquitous hydrolases in bacteria and eukaryotes. In phagocytic lower eukaryotes and professional phagocytes from higher eukaryotes, they are involved in the degradation of ingested bacteria in phagosomes.
Atsushi Furukawa +2 more
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N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases.
Chemical Communications, 2016 Mono-, di- and trisaccharide derivatives of 1,2-unsaturated N-acetyl-d-glucal have been synthesized and shown to function as tight-binding inhibitors/slow substrates of representative hexosaminidases.
A. Santana +3 more
semanticscholar +1 more source
Activities of Hexosaminidases and Hexosidases in the Brain and Spinal Cord of Rats (B. LIVING SCIENCE) [PDF]
, 1990 In the present study, activities of 4 kinds of hexosaminidases and 5 kinds of hexosidases in rat brain and spinal cord were examined. All hexosaminidases in the brain were significantly higher in activity than those in the spinal cord at p>N-acetyl-β-D ...
Katayama, Yoshiho +7 more
core +1 more source
Systematic Reviews, 2017 Background Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course.
Tatiana Raskovalova +8 more
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Molecular Phylogeny and Predicted 3D Structure of Plant beta-D-N-Acetylhexosaminidase
The Scientific World Journal, 2014 beta-D-N-Acetylhexosaminidase, a family 20 glycosyl hydrolase, catalyzes the removal of β-1,4-linked N-acetylhexosamine residues from oligosaccharides and their conjugates. We constructed phylogenetic tree of β-hexosaminidases to analyze the evolutionary
Md. Anowar Hossain, Hairul Azman Roslan
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Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives
Molecules, 2014 NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C ...
Jana Krejzová +10 more
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Agaricus bisporus Crude Extract: Characterization and Analytical Application
Molecules, 2020 In the present work crude Agaricus bisporus extract (ABE) has been prepared and characterized by its tyrosinase activity, protein composition and substrate specificity.
Maria A. Morosanova +3 more
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