Results 21 to 30 of about 2,313 (194)

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Molecules, 2018
From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors
Patrick Weber, Seyed A. Nasseri, Bettina M. Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G. Withers, Tanja M. Wrodnigg, Arnold E. Stütz   +10 more
doaj   +1 more source

Novel transmembrane receptor involved in phagosome transport of lysozymes and β-hexosaminidase in the enteric protozoan Entamoeba histolytica. [PDF]

PLoS Pathogens, 2012
Lysozymes and hexosaminidases are ubiquitous hydrolases in bacteria and eukaryotes. In phagocytic lower eukaryotes and professional phagocytes from higher eukaryotes, they are involved in the degradation of ingested bacteria in phagosomes.
Atsushi Furukawa, Kumiko Nakada-Tsukui, Tomoyoshi Nozaki   +2 more
doaj   +1 more source

Sialic acid utilization by Cronobacter sakazakii [PDF]

, 2013
Background: The Cronobacter genus is composed of seven species, and can cause infections in all age groups. Of particular concern is C. sakazakii, as this species is strongly associated with severe and often fatal cases of necrotizing enterocolitis and ...
Forsythe, S, Hariri, S, Joseph, S, Masood, N   +3 more
core   +2 more sources

Age dependence of serum beta-N-acetylhexosaminidase (NAG) activity [PDF]

, 2004
Serum Nacetyl-beta-Dglucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, bronchopulmonary dysplasia and necrotizing enterocolitis.
Goi G, Horak E, Jung K, Mandic L, O'Brien JS, Oláh VA, Price RG, Pócsi I, Shattuck KE   +8 more
core   +1 more source

Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases [PDF]

, 2016
The industrial conversion of cellulosic plant biomass into useful products such as biofuels is a major societal goal. These technologies harness diverse plant degrading enzymes, classical exo- and endo-acting cellulases and, increasingly, cellulose ...
Agirre, Agirre, Agrawal, Ask, Bacik, Barlow, Berlin, Bohlin, Bohlin, Bruno, Cannella, Cota, Cremer, Davies, Davies, Davies, Emsley, Engh, Evans, Gilbert, Harris, Henrissat, Himmel, Horn, Hudson, Imberty, Joosten, Karkehabadi, Kim, Krissinel, Krissinel, Kumar, Langston, Lima, Lombard, McNicholas, Murshudov, Pei, Pozzo, Quinlan, Ragauskas, Robinson, Rojas, Singhania, Stubbs, Suzuki, Sørensen, Thongpoo, Vagin, Vagin, Varghese, Vocadlo, Winn, Wirawan, Xin, Yoshida   +55 more
core   +2 more sources

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human : O-GlcNAcase [PDF]

, 2016
The modification of nucleocytoplasmic proteins with O-linked N-Acetylglucosamine (O-GlcNAc) plays diverse roles in multicellular organisms. Inhibitors of O-GlcNAc hydrolase (OGA), the enzyme that removes O-GlcNAc from proteins, lead to increased O-GlcNAc
Avalos Gonzalez, Bartlett, Beer, Borghgraef, Cetinbas, Copeland, Dennis, Dorfmueller, Dorfmueller, Dorfmueller, Ferrer, Gao, Graham, Greig, Haltiwanger, Hart, Khidekel, Kim, Kim, Kreppel, Kuntz, Kuzmic, Liu, Liu, Lombard, Lubas, Ma, Macauley, Macauley, Macauley, Macauley, Macauley, Mader, Mark, Mehdy, Morrison, Mosi, Murphy, Ortiz-Meoz, Ozcan, Perrin, Ranuncolo, Rao, Roeser, Ruan, Stubbs, Torres, Trinidad, Wang, Whelan, Whitworth, Yi, Yuzwa, Yuzwa, Yuzwa, Yuzwa, Zhu   +56 more
core   +1 more source

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry [PDF]

, 2018
The attachment of the sugar N-acetyl-D-glucosamine (GlcNAc) to specific serine and threonine residues on proteins is referred to as protein O-GlcNAcylation.
Aristotelous, Tonia, Borodkin, Vladimir S., Ferenbach, Andrew T., Navratilova, Iva, Rafie, Karim, Selvan, Nithya, Van Aalten, Daan M.F.   +6 more
core   +3 more sources

Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data

Systematic Reviews, 2017
Background Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course.
Tatiana Raskovalova, Patrick B. Deegan, Ruby Yang, Elena Pavlova, Jérome Stirnemann, José Labarère, Ari Zimran, Pramod K. Mistry, Marc Berger   +8 more
doaj   +1 more source

Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut [PDF]

, 2017
Bifidobacteria are common and frequently dominant members of the gut microbiota of many animals, including mammals and insects. Carbohydrates are considered key carbon sources for the gut microbiota, imposing strong selective pressure on the complex ...
Hevia, Arancha, Margolles Barros, Abelardo, Milani, Christian, Sánchez García, Borja, Ventura, Marco   +4 more
core   +1 more source

OGA Inhibition By GlcNAc-Selenazoline [PDF]

, 2010
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay.
Abdo, M., Darout, E., Hanover, J. A., Kim, E. J., Knapp, S., Love, D. C., Rablen, Paul R., Rempel, B., Withers, S. G.   +8 more
core   +2 more sources