Results 1 to 10 of about 2,313 (194)

Multivalency To Inhibit and Discriminate Hexosaminidases [PDF]

Chemistry - A European Journal, 2017
AbstractA set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity ...
Dustin T King, Jérôme Désiré, Atsushi Kato   +2 more
exaly   +8 more sources

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF [PDF]

Orphanet Journal of Rare Diseases, 2023
Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Its classic motor symptoms may be preceded by non-motor symptoms (NMS).
Matheus Vernet Machado Bressan Wilke, Fabiano Poswar, Wyllians Vendramini Borelli, Kristiane Michelin Tirelli, Dévora Natalia Randon, Franciele Fátima Lopes, Fernanda Bender Pasetto, Fernanda Medeiros Sebastião, Gabrielle Dineck Iop, Larissa Faqueti, Layzon Antonio da Silva, Francyne Kubaski, Artur Francisco Schumacher Schuh, Roberto Giugliani, Ida Vanessa Doederlein Schwartz   +14 more
doaj   +2 more sources

β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins

Frontiers in Plant Science, 2021
Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
Nicolò Alvisi, Kim van Noort, Sarlita Dwiani, Nathan Geschiere, Octavina Sukarta, Koen Varossieau, Dieu-Linh Nguyen, Richard Strasser, Cornelis H. Hokke, Arjen Schots, Ruud H. P. Wilbers   +10 more
doaj   +3 more sources

Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]

Plants
Amorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash, Barbara Bartholomew, Yana B. Penkova, Ekaterina Kozuharova   +3 more
doaj   +2 more sources

Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 β-N-acetyl-D-hexosaminidases

Frontiers in Chemistry, 2019
β-N-acetyl-D-hexosaminidases have attracted significant attention due to their crucial role in diverse physiological functions including antibacterial synergists, pathogen defense, virus infection, lysosomal storage, and protein glycosylation.
Lili Dong, Shengqiang Shen, Yefei Xu, Leng Wang, Ruirui Feng, Jianjun Zhang, Huizhe Lu   +6 more
doaj   +3 more sources

Damage of tubule cells in diabetic nephropathy type 2: Urinary N-acetyl-β-D-glucosaminidasis and γ-glutamil-transferasis [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. A damage of tubular epithelial cells is followed by the release of cell enzymes and production of proinflammatory compounds, which lead to the tubulointerstitial damage.
Vlatković Vlastimir, Stojimirović Biljana, Obrenović Radmila   +2 more
doaj   +1 more source

Structural-Functional Analysis Reveals a Specific Domain Organization in Family GH20 Hexosaminidases. [PDF]

PLoS ONE, 2015
Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates.
Cristina Val-Cid, Xevi Biarnés, Magda Faijes, Antoni Planas   +3 more
doaj   +1 more source

Chitin Degradation Machinery and Secondary Metabolite Profiles in the Marine Bacterium Pseudoalteromonas rubra S4059

Marine Drugs, 2021
Genome mining of pigmented Pseudoalteromonas has revealed a large potential for the production of bioactive compounds and hydrolytic enzymes. The purpose of the present study was to explore this bioactivity potential in a potent antibiotic and enzyme ...
Xiyan Wang, Thomas Isbrandt, Mikael Lenz Strube, Sara Skøtt Paulsen, Maike Wennekers Nielsen, Yannick Buijs, Erwin M. Schoof, Thomas Ostenfeld Larsen, Lone Gram, Sheng-Da Zhang   +9 more
doaj   +1 more source

Characterization of inducible models of Tay-Sachs and related disease. [PDF]

PLoS Genetics, 2012
Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system.
Timothy J Sargeant, Deborah J Drage, Susan Wang, Apostolos A Apostolakis, Timothy M Cox, M Begoña Cachón-González   +5 more
doaj   +1 more source

Human kidney hexosaminidase A and hexosaminidase B form a complex [PDF]

European Journal of Biochemistry, 1991
The isolation and purification of human kidney hexosaminidases A and B was carried out. Regulation of the supramolecular organization and catalytic activity of hexosaminidases was investigated in the bis(2‐ethylhexyl)sulphosuccinate reversed micellar system modeling the enzyme microenvironment in the lysosomes. It was shown that hexosaminidases A and B
A V, Pshezhetsky, O A, Buneeva, V M, Dvorkin   +2 more
openaire   +2 more sources