Results 1 to 10 of about 7,764 (216)

β-Hexosaminidases Along the Secretory Pathway of Nicotiana benthamiana Have Distinct Specificities Toward Engineered Helminth N-Glycans on Recombinant Glycoproteins [PDF]

Frontiers in Plant Science, 2021
Secretions of parasitic worms (helminths) contain a wide collection of immunomodulatory glycoproteins with the potential to treat inflammatory disorders, like autoimmune diseases.
Richard Strasser, Arjen Schots, Ruud Wilbers   +2 more
exaly   +5 more sources

Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 β-N-acetyl-D-hexosaminidases [PDF]

Frontiers in Chemistry, 2019
β-N-acetyl-D-hexosaminidases have attracted significant attention due to their crucial role in diverse physiological functions including antibacterial synergists, pathogen defense, virus infection, lysosomal storage, and protein glycosylation.
Shen Shengqiang, Huizhe Lu, Jianjun Zhang   +2 more
exaly   +5 more sources

Multivalency To Inhibit and Discriminate Hexosaminidases [PDF]

Chemistry - A European Journal, 2017
AbstractA set of multivalent polyhydroxylated acetamidoazepanes based on ethylene glycol, glucoside, or cyclodextrin scaffolds was prepared. The compounds were assessed against plant, mammalian, and therapeutically relevant hexosaminidases. Multimerization was shown to improve the inhibitory potency with synergy, and to fine tune the selectivity ...
David Vočadlo, Atsushi Kato, Sébastien Gouin   +2 more
exaly   +9 more sources

Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris [PDF]

Universitas Scientiarum, 2016
β-hexosaminidases (Hex) are dimeric enzymes involved in the lysosomal degradation of glycolipids and glycans. They are formed by α- and/or β-subunits encoded byHEXA and HEXB genes, respectively.
Angela Johana Espejo Mojica, Angela Rocío Mosquera, Edwin Alexander Rodríguez-López, Dennis Johana Díaz, Laura Milena Betrán, Francy Liliana Hernández, Carlos Javier Alméciga Díaz, Luis Alejandro Barrera   +7 more
doaj   +14 more sources

Structural-Functional Analysis Reveals a Specific Domain Organization in Family GH20 Hexosaminidases. [PDF]

PLoS ONE, 2015
Hexosaminidases are involved in important biological processes catalyzing the hydrolysis of N-acetyl-hexosaminyl residues in glycosaminoglycans and glycoconjugates.
Cristina Val-Cid, Xevi Biarnés, Magda Faijes, Antoni Planas   +3 more
doaj   +5 more sources

Human recombinant lysosomal β‐Hexosaminidases produced in Pichia pastoris efficiently reduced lipid accumulation in Tay‐Sachs fibroblasts [PDF]

American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 2020
GM2 gangliosidosis, Tay‐Sachs and Sandhoff diseases, are lysosomal storage disorders characterized by the lysosomal accumulation of GM2 gangliosides. This accumulation is due to deficiency in the activity of the β‐hexosaminidases Hex‐A or Hex‐B, which ...
Alexander Rodríguez-López, Almeciga-Díaz Carlos J   +1 more
exaly   +3 more sources

Follow-up of pre-motor symptoms of Parkinson’s disease in adult patients with Gaucher disease type 1 and analysis of their lysosomal enzyme profiles in the CSF [PDF]

Orphanet Journal of Rare Diseases, 2023
Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Its classic motor symptoms may be preceded by non-motor symptoms (NMS).
Matheus Vernet Machado Bressan Wilke, Fabiano Poswar, Wyllians Vendramini Borelli, Kristiane Michelin Tirelli, Dévora Natalia Randon, Franciele Fátima Lopes, Fernanda Bender Pasetto, Fernanda Medeiros Sebastião, Gabrielle Dineck Iop, Larissa Faqueti, Layzon Antonio da Silva, Francyne Kubaski, Artur Francisco Schumacher Schuh, Roberto Giugliani, Ida Vanessa Doederlein Schwartz   +14 more
doaj   +2 more sources

Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]

Plants
Amorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash, Barbara Bartholomew, Yana B. Penkova, Ekaterina Kozuharova   +3 more
doaj   +2 more sources

Isolation and Relationship of Human Hexosaminidases

Journal of Biological Chemistry, 1974
A method for the preparation of highly purified β-hexosaminidase isozymes A and B from human placenta is presented. The purified enzymes possess identical molecular weight and exhibit similar kinetic parameters with artificial fluorogenic substrates.
J F, Tallman, R O, Brady, J M, Quirk, M, Villalba, A E, Gal   +4 more
openaire   +3 more sources

Automated Assay of Hexosaminidases in Serum

Clinical Chemistry, 1973
Abstract In serum there are two classes of hexosaminidase. One of these is heat-labile and is inactive in children with Tay—Sachs disease. Serum from heterozygotes for Tay—Sachs disease has half the normal activity of the heat-labile enzyme.
J A, Lowden, M A, Skomorowski, F, Henderson, M, Kaback   +3 more
openaire   +3 more sources