Results 11 to 20 of about 7,764 (216)

The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases [PDF]

Journal of Biological Chemistry, 2021
Endo-β-N-acetylmuramidases, commonly known as lysozymes, are well-characterized antimicrobial enzymes that catalyze an endo-lytic cleavage of peptidoglycan; i.e., they hydrolyze the β-1,4-glycosidic bonds connecting N-acetylmuramic acid (MurNAc) and N ...
Maraike Müller, M. Calvert, Isabel Hottmann, R. Kluj, Tim Teufel, Katja Balbuchta, Alicia Engelbrecht, K. Selim, Qingping Xu, Marina Borisova, A. Titz, C. Mayer   +11 more
semanticscholar   +3 more sources

Bicistronic lentiviral vector corrects β-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts

Neurobiology of Disease, 2005
Sandhoff disease is an autosomal recessive neurodegenerative disease characterized by a GM2 ganglioside intralysosomal accumulation. It is due to mutations in the β-hexosaminidases β-chain gene, resulting in a β-hexosaminidases A (αβ) and B (ββ ...
Audrey Arfi, Christophe Bourgoin, Luisa Basso, Carla Emiliani, Brunella Tancini, Vanna Chigorno, Yu-Teh Li, Aldo Orlacchio, Livia Poenaru, Sandro Sonnino, Catherine Caillaud   +10 more
doaj   +2 more sources

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases [PDF]

Chemistry and Biology, 2010
Summary Posttranslational modification of metazoan nucleocytoplasmic proteins with N-acetylglucosamine (O-GlcNAc) is essential, dynamic, and inducible and can compete with protein phosphorylation in signal transduction.
H. Dorfmueller, V. Borodkin, M. Schimpl, Xiaowei Zheng, Robert Kime, K. Read, D. V. van Aalten   +6 more
semanticscholar   +2 more sources

Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

Molecules, 2018
From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors
Patrick Weber, Seyed A. Nasseri, Bettina M. Pabst, Ana Torvisco, Philipp Müller, Eduard Paschke, Marion Tschernutter, Werner Windischhofer, Stephen G. Withers, Tanja M. Wrodnigg, Arnold E. Stütz   +10 more
doaj   +2 more sources

Damage of tubule cells in diabetic nephropathy type 2: Urinary N-acetyl-β-D-glucosaminidasis and γ-glutamil-transferasis [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. A damage of tubular epithelial cells is followed by the release of cell enzymes and production of proinflammatory compounds, which lead to the tubulointerstitial damage.
Vlatković Vlastimir, Stojimirović Biljana, Obrenović Radmila   +2 more
doaj   +1 more source

Bioinformatic, Enzymatic, and Structural Characterization of <i>Trichuris suis</i> Hexosaminidase HEX-2. [PDF]

Biochemistry
Hexosaminidases are key enzymes in glycoconjugate metabolism and occur in all kingdoms of life. Here, we have investigated the phylogeny of the GH20 glycosyl hydrolase family in nematodes and identified a ?-hexosaminidase subclade present only in the ...
Dutkiewicz Z, Varrot A, Breese KJ, Stubbs KA, Nuschy L, Adduci I, Paschinger K, Wilson IBH.   +7 more
europepmc   +2 more sources

Human kidney hexosaminidase A and hexosaminidase B form a complex [PDF]

European Journal of Biochemistry, 1991
The isolation and purification of human kidney hexosaminidases A and B was carried out. Regulation of the supramolecular organization and catalytic activity of hexosaminidases was investigated in the bis(2‐ethylhexyl)sulphosuccinate reversed micellar system modeling the enzyme microenvironment in the lysosomes. It was shown that hexosaminidases A and B
A V, Pshezhetsky, O A, Buneeva, V M, Dvorkin   +2 more
openaire   +2 more sources

The subunits of human hexosaminidase A [PDF]

Biochemical Journal, 1976
Previous studies of the subunit structure of hexosaminidase gave ambiguous results, but suggested that the enzyme was composed of six equally sized subunits. Dissociation of hexosaminidase A with p-chloromercuribenzoate produces an alkylated fragment with mol.wt. approx.
E, Beutler, A, Yoshida, W, Kuhl, J E, Lee   +3 more
openaire   +2 more sources

Chitin Degradation Machinery and Secondary Metabolite Profiles in the Marine Bacterium Pseudoalteromonas rubra S4059

Marine Drugs, 2021
Genome mining of pigmented Pseudoalteromonas has revealed a large potential for the production of bioactive compounds and hydrolytic enzymes. The purpose of the present study was to explore this bioactivity potential in a potent antibiotic and enzyme ...
Xiyan Wang, Thomas Isbrandt, Mikael Lenz Strube, Sara Skøtt Paulsen, Maike Wennekers Nielsen, Yannick Buijs, Erwin M. Schoof, Thomas Ostenfeld Larsen, Lone Gram, Sheng-Da Zhang   +9 more
doaj   +1 more source

Characterization of inducible models of Tay-Sachs and related disease. [PDF]

PLoS Genetics, 2012
Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system.
Timothy J Sargeant, Deborah J Drage, Susan Wang, Apostolos A Apostolakis, Timothy M Cox, M Begoña Cachón-González   +5 more
doaj   +1 more source