Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu. [PDF]
Sci Rep, 2021 Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Although hyperglycaemia has been determined as the most important risk factor, hypoxia also plays a relevant role in the development of this disease.
Valdés A +5 more
europepmc +3 more sources
Molybdenum Nanofertilizer Boosts Biological Nitrogen Fixation and Yield of Soybean through Delaying Nodule Senescence and Nutrition Enhancement [PDF]
, 2023 Soybean (Glycine max) is a crop of global significance and has low reliance on N fertilizers due to its biological nitrogen fixation (BNF) capacity, which harvests ambient N2 as a critical ecosystem service.
Cao, Weidong +12 more
core +1 more source
HepatoDyn: a dynamic model of hepatocyte metabolism that integrates 13C isotopomer data [PDF]
, 2016 The liver performs many essential metabolic functions, which can be studied using computational models of hepatocytes. Here we present HepatoDyn, a highly detailed dynamic model of hepatocyte metabolism.
Atauri Carulla, Ramón de +7 more
core +1 more source
Allotetraploidization in Brachypodium May Have Led to the Dominance of One Parent’s Metabolome in Germinating Seeds [PDF]
, 2021 Seed germination is a complex process during which a mature seed resumes metabolic activity to prepare for seedling growth. In this study, we performed a comparative metabolomic analysis of the embryo and endosperm using the community standard lines of ...
Beckmann, Manfred +5 more
core +2 more sources
Zinc Treatment Reverses and anti-Zn-Regulated miRs Suppress Esophageal Carcinomas In Vivo [PDF]
, 2023 Esophageal squamous cell carcinoma (ESCC) is a deadly disease with few prevention or treatment options. ESCC development in humans and rodents is associated with Zn deficiency (ZD), inflammation, and overexpression of oncogenic microRNAs: miR-31 and miR ...
Brydges, Christopher R +7 more
core +1 more source
Bacterial Inoculation and Extracts of Opuntia Rackets or Marine Algae Trigger Distinct Proline Balances in Tomato Salt Stress Alleviation [PDF]
, 2023 High salt levels in soil can severely limit plant development and diminish the positive effect of plant-growth-promoting rhizobacteria (PGPR). However, extracts of organisms adapted to high salinity, such as Opuntia ficus-indica (OFI) and Enteromorpha ...
Cruz, Cristina +5 more
core +1 more source
Substraatvoorziening van de oxidatieve fosforylering in geisoleerde rattethymuskernen [PDF]
, 1969 It has been established that isolated thymus nuclei are, in contrast to nuclei isolated from liver, heart or kidney, capable of a respiratory-chain-linked oxidative phosphorylation.
Konings, Antonius Wilhelmus Theodorus
core +4 more sources
Current Challenges in Modeling Cellular Metabolism [PDF]
, 2016 Mathematical and computational models play an essential role in understanding the cellular metabolism. They are used as platforms to integrate current knowledge on a biological system and to systematically test and predict the effect of manipulations to ...
core +1 more source
Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria-causing parasites [PDF]
, 2021 The malaria-causing parasite Plasmodium falciparum is responsible for over 200 million infections and 400,000 deaths per year. At multiple stages during its complex life cycle, P. falciparum expresses several essential proteins tethered to its surface by
Frasse, Philip M +8 more
core +2 more sources
Deciphering the physiological response of Escherichia coli under high ATP demand [PDF]
, 2021 One long‐standing question in microbiology is how microbes buffer perturbations in energy metabolism. In this study, we systematically analyzed the impact of different levels of ATP demand in Escherichia coli under various conditions (aerobic and ...
Boecker, S. +6 more
core +1 more source