Results 21 to 30 of about 1,403 (75)

Measuring catalytic mechanism similarity – a new approach to study enzyme function and evolution

The FEBS Journal, Volume 292, Issue 16, Page 4200-4210, August 2025.
We introduce a previously undescribed computational method to measure the similarity of enzyme mechanisms, enabling comparison of catalytic steps across hundreds of enzymes. Applying this method to a database of enzyme mechanisms demonstrated its ability to automatically uncover functional and evolutionary relationships, independently of sequence and ...
Antonio J. M. Ribeiro, Ioannis G. Riziotis, Neera Borkakoti, Pedro A. Fernandes, Maria J. Ramos, Janet M. Thornton   +5 more
wiley   +1 more source

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

New Plant Protection, Volume 2, Issue 2, June 2025.
Applying population genomics, this study revealed that Pst exhibits slower linkage disequilibrium decay compared to rust fungi with known sexual reproduction, identified extensive hard and soft sweeps linked to Pst adaptation, and demonstrated that crop domestication and breeding programs have significantly influenced pathogen population sizes ...
Yun Xing, Chongjing Xia, Liang Huang, Na Zhao, Hongfu Li, Xingzong Zhang, Age Qiu, Wanqiang Tang, Meinan Wang, Xianming Chen, Bo Liu, Hao Zhang, Li Gao, Wanquan Chen, Taiguo Liu   +14 more
wiley   +1 more source

Comparative Transcriptomic Analysis of AtBBX29 Transgenic and Wild Type Sugarcane Exposed to Drought Stress

Physiologia Plantarum, Volume 177, Issue 3, May/June 2025.
ABSTRACT Previously, we produced drought‐tolerant transgenic sugarcane plants that overexpressed the AtBBX29 gene, which encodes a transcription factor (TF) B‐box protein. These plants displayed delayed senescence, were able to maintain photosynthesis, and accumulated high levels of antioxidants and osmolytes when exposed to water deficit stress ...
Christell van der Vyver, Preetom Regon, Kristen Fulton, Sanjib K. Panda   +3 more
wiley   +1 more source

Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
In Pggt1b‐deficient macrophages, TLR4 may be in a highly activated state and can be activated by R848 or DAMPS, which strongly correlated with increased cytokine production, interferon‐γ production, augmented amide binding and transferase activity, and the activation of NF‐κB and/or Nlrp3 inflammasome pathways.
Shanshan Yu, Xuecui Wei, Fangyuan Long, Heng Gu, Zhimin Hao   +4 more
wiley   +1 more source

De novo Whole‐Genome Assembly of the 10‐Gigabase Fokienia Hodginsii Genome to Reveal Differential Epigenetic Events Between Callus and Xylem

Advanced Science, Volume 11, Issue 40, October 28, 2024.
This study presents a chromosome‐level genome assembly of Fokienia hodginsii, a gymnosperm with valuable wood properties. Utilizing advanced sequencing technologies, the research constructs a 10G genome across 11 chromosomes, annotates over 50 000 genes.
Jundong Rong, Yushan Zheng, Zeyu Zhang, Jun Zhang, Yuying Gu, Tian Hua, Mengna Zhao, Lili Fan, Zhiwen Deng, Yanmei Pan, Bingjun Li, Liguang Chen, Tianyou He, Lingyan Chen, Jing Ye, Hangxiao Zhang, Lianfeng Gu   +16 more
wiley   +1 more source

Pathogenic DDOST Variant Is Associated with Humoral Immune Deficiency. [PDF]

J Clin Immunol, 2023
Sitek A, Ligezka A, Budhraja R, Morava E, Chiarella SE.   +4 more
europepmc   +1 more source

Innovative Immobilization of <i>Aspergillus aculeatus</i> OI4C2 Fructosyltransferase on MANAE-Agarose Cross-Linked with Genipin for Enhanced Production of Fructooligosaccharides. [PDF]

J Agric Food Chem
Inagaki TS, de Andrades D, Souza Alves Picciarelli G, Polizeli MLTM, Poleto de Oliveira D, Pereira de Carvalho Junior V, Helfenstein Rother PD, Fabricio MF, Ayub MAZ, Hertz PF, Kadowaki MK.   +10 more
europepmc   +1 more source

Expanded Clinical Spectrum of Autosomal-Dominant STT3A-CDG. [PDF]

Biomolecules
Al-Shahrani H, Szabó E, Staccone C, MacDonald G, Furuta Y, Schecter D, Edmondson AC, McRae A, Baker J, Morava E, Tinker RJ.   +10 more
europepmc   +1 more source

Transcriptomic dissection of floral identity and trichome-derived metabolite pathways in Cannabis sativa L. [PDF]

Planta
Barbosa-Xavier K, Venancio TM.
europepmc   +1 more source

HMGN2 induces pyroptosis in tumour cells by modulating the STT3B/PD‑L1/caspase‑1/GSDMD axis. [PDF]

Mol Med Rep
Han W, Chen H, Cui B, Chen J, Zhang P, Feng Y.   +5 more
europepmc   +1 more source