Results 41 to 50 of about 817,589 (162)

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, Volume 15, Issue 10, Page 1552-1569, October 2025.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Molecular Evolution and Gene Diversity of Dermatan Sulfate Sulfotransferases in Ascidians

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT Ascidians (Chordata, Tunicata) are model organisms for studying molecules, particularly sulfated glycosaminoglycans (GAGs), due to their phylogenetic proximity to vertebrates and unique GAG variants. Over‐sulfated dermatan sulfate (DS) contributes to proteoglycan diversity and cellular processes in metazoans.
Vanessa de Sousa Rizzo‐Valente, Mauro S. G. Pavão   +1 more
wiley   +1 more source

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar, Clément Daviaud, Hugo Main, Rachel Havret, Claire Debarnot, Laure Favot‐Laforge, Jean‐François Jégou, Ingrid Fruitier‐Arnaudin, Antoine Dufour, Romain Vivès, Franck Morel, Yves Bourne, Kévin Baranger   +12 more
wiley   +1 more source

Anacardic Acids and Ferric Ion Chelation [PDF]

, 2007
6-Pentadeca(e)nylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae), commonly known as anacardic acids, inhibited the linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, type 1) competitively ...
Hayashi, Akio, Tsujimoto, Kazuo, Joung Ha, Tae, Kubo, Isao   +3 more
core  

Amino acids and central fatigue

, 2001
There is an increasing interest in the mechanisms behind central fatigue, particularly in relation to changes in brain monoamine metabolism and the influence of specific amino acids on fatigue.
Blomstrand, Eva,, Blomstrand, E
core   +1 more source

Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria [PDF]

, 2007
Background. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall.
Robert C Reynolds, Coxon, Geoffrey D., Dover, Lynn, Geoffrey D Coxon, Besra, Gurdyal; id_orcid, Besra, Gurdyal S., Besra, Gurdyal, Dover, Lynn G., Reynolds, Robert C., Laurent Kremer, Trivelli, X, Trivelli, Xavier, James C Sacchettini, Sacchettini, JC, Anuradha Alahari, Lynn G Dover, Kremer, Laurent, Kremer, L, Guérardel, Yann, Dover, Lynn G, Coxon, Geoffrey D, Coxon, GD, Gurdyal S Besra, Sacchettini, James C., Reynolds, Robert, Yann Guérardel, Reynolds, Robert C, Reynolds, RC, Coxon, Geoffrey, Gu��rardel, Yann, Alahari, Anuradha, Sacchettini, James C, Gu rardel, Y, Alahari, A, Besra, Gurdyal S, Xavier Trivelli, El-Shemy, Hany, Sacchettini, James   +37 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, Volume 599, Issue 15, Page 2190-2200, August 2025.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

The inhibition of T-lymphocyte proliferation by fatty acids is via an eicosanoid-independent mechanism

, 1992
Eicosanoids, in particular prostaglandin E2 (PGE2), are potent inhibitors of a number of immune responses, including lymphocyte proliferation. We have previously shown that fatty acids, especially polyunsaturated fatty acids (PUFA), inhibit mitogen ...
Calder, P.C., Newsholme, E.A., Bevan, S.J.   +2 more
core   +1 more source

Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
This study investigates the phytochemical composition and biopharmacological potential of the extracts from three Hypericum species (H. scabrum, H. lysimachioides, and H. uniglandulosum) from Turkey. The results indicate significant therapeutic potential for these extracts, supporting their development as natural agents against oxidative stress ...
Muammer Bahsi, Simonetta Cristina Di Simone, Dimitrina Zheleva‐Dimitrova, Gokhan Zengin, Gaia Cusumano, Giancarlo Angeles Flores, Paola Angelini, Carla Emiliani, Mehmet Veysi Cetiz, Annalisa Chiavaroli, Luigi Menghini, Guistino Orlando, Claudio Ferrante   +12 more
wiley   +1 more source

Alveolar Glycocalyces During Health and Critical Illness

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source