Results 41 to 50 of about 2,790 (157)

Oligosaccharides mapping of nitrous acid degraded heparin through UHPLC-HILIC/WAX-MS [PDF]

, 2020
Building blocks characterization is a significant approach for understanding the molecular structure of heparin and its derivatives. Nitrous acid (HONO) depolymerization of heparin generates oligosaccharides that maintain the epimerization conformation ...
Chi, Lianli,, Zhang, Tianji,, Tan, Tianwei,, Sun, Qianyun,, Li, Jin-Ping,, Xie, Shaoshuai,, Zhang, Rui,, Liu, Xin,, Wang, Zhangjie,, Li, Hongmei,   +9 more
core   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, Volume 15, Issue 10, Page 1552-1569, October 2025.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Molecular Evolution and Gene Diversity of Dermatan Sulfate Sulfotransferases in Ascidians

Proteoglycan Research, Volume 3, Issue 4, October 2025.
ABSTRACT Ascidians (Chordata, Tunicata) are model organisms for studying molecules, particularly sulfated glycosaminoglycans (GAGs), due to their phylogenetic proximity to vertebrates and unique GAG variants. Over‐sulfated dermatan sulfate (DS) contributes to proteoglycan diversity and cellular processes in metazoans.
Vanessa de Sousa Rizzo‐Valente, Mauro S. G. Pavão   +1 more
wiley   +1 more source

The Pathophysiological Functions of Heparanases: From Evolution, Structural and Tissue‐Specific Perspectives

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Heparanase 1 (HPSE1) and Heparanase 2 (HPSE2) exhibit opposing expression patterns and functions in pathological contexts, such as cancer. Here, we describe their specific expression in immune cells and their implications in skin diseases. Although they are structurally similar and considered to be ‘cousins’, we found no common ancestor and that HPSE2 ...
Elham Vahdatahar, Clément Daviaud, Hugo Main, Rachel Havret, Claire Debarnot, Laure Favot‐Laforge, Jean‐François Jégou, Ingrid Fruitier‐Arnaudin, Antoine Dufour, Romain Vivès, Franck Morel, Yves Bourne, Kévin Baranger   +12 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, Volume 599, Issue 15, Page 2190-2200, August 2025.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
This study investigates the phytochemical composition and biopharmacological potential of the extracts from three Hypericum species (H. scabrum, H. lysimachioides, and H. uniglandulosum) from Turkey. The results indicate significant therapeutic potential for these extracts, supporting their development as natural agents against oxidative stress ...
Muammer Bahsi, Simonetta Cristina Di Simone, Dimitrina Zheleva‐Dimitrova, Gokhan Zengin, Gaia Cusumano, Giancarlo Angeles Flores, Paola Angelini, Carla Emiliani, Mehmet Veysi Cetiz, Annalisa Chiavaroli, Luigi Menghini, Guistino Orlando, Claudio Ferrante   +12 more
wiley   +1 more source

Alveolar Glycocalyces During Health and Critical Illness

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source

The state of the connective tissue in patients with peptic ulcer accompanied by lesions of the hepatobiliary system in the dynamics of treatment by "Erbisol" [PDF]

, 2000
Дослідження проведені у 54 хворих на виразкову хворобу з супутнім ураженням гепатобіліарної системи. При цьому встановлений позитивний вплив "Ербісолу'' на стан сполучної тканини, про що свідчить підвищення коефіцієнту відношення вмісту білковозв'язаного
Федів, Олександр Іванович, Fediv, O.I.   +1 more
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Disaccharide Analysis of Glycosaminoglycans From Twenty‐Four Organs of Young and Aged Mice

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT Glycosaminoglycans (GAGs) are abundant negatively charged polysaccharides ubiquitously expressed in mammalian organs, having essential biological functions in development and homeostasis. It has been scarcely reported that GAG structures are changed in aged and diseased human organs; however, an overall landscape of GAGs in individual organs ...
Emil Tykesson, Malin Eriksson, Jin‐Ping Li, Marco Maccarana   +3 more
wiley   +1 more source

Salivary diagnostics is informative method for assessment of stress reactivity in people [PDF]

, 2013
У статті наведено дослідження біохімічних показників ротової рідини – вмісту кортизолу та гексуронових кислот у людей, що знаходились у стані природного психоемоційного напруження.
Цубер, Вікторія Юріївна, Tsuber, V. Yu., Тарасенко, Костянтин Володимирович, Омельченко, Александр Евгеньевич, Омельченко, Олександр Євгенійович, Omelchenko, А. Е., Цубер, Виктория Юрьевна, Тарасенко, Константин Владимирович, Tarasenko, K. V.   +8 more
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