Results 31 to 40 of about 461,020 (267)

Research Advances in Targeted Therapy for Heart Failure

Reviews in Cardiovascular Medicine, 2023
Cardiovascular disease is one of the major diseases threatening the health of Chinese residents, and the death rate has long been the highest on the disease spectrum in China.
Liu Miao, Yan-Li Liu
doaj   +1 more source

Comparison of Hartree Factor and Density Function Theory in Calculating Coating Constants and NMR Parameters of Chromate and Molecular Complexes with Alanine and Glycine [PDF]

International Journal of New Chemistry, 2017
Chromium and molybdenum are intermediate elements of a periodic table group, both of which are both low but essential in nutrition because they play a key role in the metabolism of the chemical activity of the body.
Vinod Nguyen
doaj   +1 more source

Comparison of Symptomatic and Functional Responses to Vagus Nerve Stimulation in ANTHEM-HF, INOVATE-HF, and NECTAR-HF [PDF]

ESC Heart Failure, 2020
Abstract Aims Clinical studies of vagal nerve stimulation (VNS) for heart failure with reduced ejection fraction have had mixed results to date. We sought to compare VNS delivery and associated changes in symptoms and function in autonomic regulation therapy via left or right cervical vagus ...
Anand, Inder S, Konstam, Marvin A, Klein, Helmut U, Mann, Douglas L, Ardell, Jeffrey L, Gregory, Douglas D, Massaro, Joseph M, Libbus, Imad, DiCarlo, Lorenzo A, Udelson, John James E, Butler, Javed, Parker, John D, Teerlink, John R   +12 more
openaire   +5 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Comparison of frequency domain parameters of heart rate variability between women with polycystic ovarian disease and apparently healthy women

Journal of Family Medicine and Primary Care, 2022
Background: Polycystic ovary syndrome (PCOS) patients shows common features like increased insulin resistance and adiposity, which have been known to correlate with sympathetic hyperactivity.
Ritu Tiwari, Manish Bajpai, Sunita Tiwari, Smriti Agrawal   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evalueringsrapport. Steiner HF

, 2023
Denne rapport har til formål at sammenfatte, hvordan HF-uddannelsen på Steinersko-lerne har fungeret, siden den implementeredes i 2018. Evalueringen har over en 2-årig periode fulgt to hovedspor, nemlig på den ene side et spørgeskema til alle elever på Steiner HF og på den anden side kvalitative interviews med rektorer og lærere ved de 5 HF-skoler ...
Niels Rosendal Jensen,, Malene Engsig Brodersen, Naya Hansen   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Studies of dispersion energy in hydrogen-bonded systems. H2O–HOH, H2O–HF, H3N–HF, HF–HF

The Journal of Chemical Physics, 1984
Dispersion energy is calculated in the systems H2O–HOH, H2O–HF, H3N–HF, and HF–HF as a function of the intermolecular separation using a variety of methods. M≂ller–Plesset perturbation theory to second and third orders is applied in conjunction with polarized basis sets of 6-311G** type and with an extended basis set including a second set of ...
Szczesniak, M. M., Scheiner, Steve
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source