Results 111 to 120 of about 20,268 (224)

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

HFpEF

JACC: Heart Failure, 2018
openaire   +1 more source

Circular RNAs: Unlocking new avenues in cardiometabolic disease management

The Journal of Physiology, EarlyView.
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor, Thomas D. Donelly, Gerald L.M. Naepi, Glenn D. Wadley, Bianca C. Bernardo   +4 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Noncoding and coding mechanisms of aging-related heart failure with preserved ejection fraction associated with thyroid dysfunction

Disease Models & Mechanisms
Sankalpa Chakraborty, Olivia Sloan, Bryce Dickerson, Gourav Chakraborty, Shuang Li, Curren Bounds, Sophia Lemus, Caleb Hickman, J. Mauro Calabrese, Viswanathan Rajagopalan   +9 more
doaj   +1 more source

PVRI‐GoDeep—A Global Meta‐Registry at the Crossroads of Heart and Lung

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
PVRI GoDeep is a global meta‐registry that harmonizes high‐quality patient‐level data from pulmonary hypertension registries worldwide. With over 45,000 enrolees already included, it enables robust phenotyping, international comparisons, and clinically relevant research across all PH subgroups beyond the scope of single‐center or national datasets ...
Meike T. Fuenderich, Athiththan Yogeswaran, Patrick Janetzko, Khodr Tello, Werner Seeger, Raphael W. Majeed, Jochen Wilhelm, GoDeep Consortium, Mauro Acquaro, Imad Al Ghouleh, James Anderson, Jeffrey S. Annis, Anastasia Anthi, Alexandra Arvanitaki, Aparna Balasubramanian, Felix Ballmann, Harm Jan Bogaard, Evan Brittain, Hugh Buzacott, Hector R. Cajigas, John Cannon, Stephen Y. Chan, Victoria Damonte, Effrosyni Dima, Philipp Douschan, Nathan Dwyer, Diego Echazarreta, Christina A. Eichstaedt, Jean Elwing, Kai Förster, Robert Frantz, Marlize Frauendorf, Stefano Ghio, Hossein‐Ardeschir Ghofrani, George Giannakoulas, Friedrich Grimminger, Ekkehard Grünig, Lars Harbaum, Paul M. Hassoun, Melanie Heberling, Anne Hilgendorff, Luke Howard, Arun Jose, Ernesto Junaeda, David G. Kiely, Ingrid King, Hans Klose, Ziad Konswa, Gabor Kovacs, Philipp Krieb, Keiichiro Kuronuma, Edmund M. Lau, Melanie Lavender, Allan Lawrie, Mona Lichtblau, Kurt Marquardt, Hiromi Matsubara, Farhan Mubashir, Horst Olschewski, Mauricio Orozco‐Levi, Karen Osborn, Joanna Pepke‐Zaba, Alba Ramirez‐Sarmiento, Stephan Rosenkranz, Hani Sabbour, Sandeep Sahay, Khaled Saleh, Laura Scelsi, Yuriy Sirenko, Siva Sivakumaran, Andrew J. Sweatt, Thenappan Thenappan, Ioan Tilea, Olena Torbas, Silvia Ulrich, Andrea Varga, Helen M. Whitford, Christoph B. Wiedenroth, Martin R. Wilkins, Paul G. Williams, Shaun Yo, Roham T. Zamanian, Zhenguo Zhai, Zhu Zhang   +83 more
wiley   +1 more source

Early administration of renin-angiotensin system inhibitors improves survival and cardiac remodeling in heart failure with preserved ejection fraction. [PDF]

PLoS One
Kono Y, Sonoda K, Ohtake K, Ota A, Yamamoto S, Nakayama H, Fukuoka T, Kawai Y, Tago H, Watanabe N, Sato I, Hirohata S, Kitamori K, Watanabe S.   +13 more
europepmc   +1 more source

A Scoping Review of Pharmacist‐Based Interprofessional Interventions for Management of Cardiovascular‐Kidney‐Metabolic Conditions

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 4, April 2026.
ABSTRACT Background Co‐existence of multiple cardiovascular‐kidney‐metabolic (CKM) conditions, such as chronic kidney disease (CKD), type 2 diabetes (T2D), and cardiovascular disease, is common. The interconnected nature of CKM conditions emphasizes the need for an interprofessional approach to patient care.
Wendy L. St. Peter, Joshua J. Neumiller, Radica Alicic, Sheryl L. Chow, Hadley Dowell, O. Kenrik Duru, Patrick Gee, Roy O. Mathew, Susanne B. Nicholas, Janani Rangaswami, Glenda V. Roberts, Muthiah Vaduganathan, Katherine R. Tuttle   +12 more
wiley   +1 more source

Flipping the focus - treating post-capillary pulmonary hypertension with pulmonary artery denervation. [PDF]

AsiaIntervention
Hart JP, Davies MG.
europepmc   +1 more source