Results 171 to 180 of about 34,947 (279)

Diagnosing HFpEF

JACC: Cardiovascular Imaging, 2018
openaire   +1 more source

Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
HFD withdrawal results in early restoration of systemic glucose tolerance and PVAT lipid unsaturation that is temporarily dissociated from the reversal of endothelial dysfunction in aorta that may be linked to altered PVAT function featured by impaired guanylate cyclase signaling pathway.
Krzysztof Czamara, Izabela Czyzynska‐Cichon, Anna Bar, Ewa Stanek, Mateusz Wawro, Marta Z. Pacia, Zeinep Berkimbayeva, Brygida Marczyk, Elvira Bragado‐García, Paloma Palma‐Guzman, Maria S. Fernandez‐Alfonso, Stefan Chlopicki   +11 more
wiley   +1 more source

Pre- and post-diagnosis signalling lipid profiles in heart failure with preserved ejection fraction: a prospective cohort study. [PDF]

EBioMedicine
Zhang L, Szili-Torok T, Lamont L, Kindt A, Harms A, Bakker SJL, Gansevoort R, de Borst MH, Hankemeier T.   +8 more
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

MARCH1 Deletion Attenuates HFpEF by Promoting Adipose Beiging. [PDF]

Compr Physiol
Zhu Y, Fan J, Tang L, Zhou Y, Jiang K, Tan D, Huang H, Wu M, Zeng J, Yang H, Zhou S.   +10 more
europepmc   +1 more source

Circulating Level of Growth‐Differentiation Factor 15 and Mortality of Patients With Acute Heart Failure: A Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Elevated admission GDF‐15 levels are associated with increased mortality in acute heart failure. This meta‐analysis of 10 studies (N = 3724) found a pooled RR of 2.82 (95% CI: 2.39–3.32; p < 0.001; I² = 0%), supporting GDF‐15 as a promising biomarker for early risk stratification in AHF patients.
Pingkui Jin, Yanjie Geng, Erwei Huo, Yanhong Xue, Daofeng You, Qinghou Zheng   +5 more
wiley   +1 more source

IGFBP7 and Heart Failure: From Senescence Biomarker to Therapeutic Target. [PDF]

Curr Heart Fail Rep
El-Qendouci M, Chelu R, Abdellatif M, Jhund P, de Boer RA, Suthahar N.   +5 more
europepmc   +1 more source

Clinical Research Nurses, an Untapped Resource of Nurse Researchers?

Nursing Open, Volume 13, Issue 5, May 2026.
ABSTRACT The clinical research nurse (CRN) workforce in the United Kingdom (UK) is considerable and has a level of expertise when it comes to delivering research in a healthcare setting. Yet these same individuals are often overlooked when it comes to developing future academic nursing research leaders within the UK.
Faye Forsyth, Miriam Avery, Sandra Bartolomeu Pires, Chantelle Moorbey, Layla Bolton Saghdaoui, Amanda Skinner, Vittoria Sorice, Mary Harrison, Rosalynn C. Austin   +8 more
wiley   +1 more source

Large language model detects previously undiagnosed heart failure with preserved ejection fraction in patients with metabolic-associated fatty liver disease: A multicenter cohort study. [PDF]

PLOS Digit Health
Lu X, Wang X, Liu D, Zhang Z, Zhang Y, Zhang T, Lu D, Kuang S, Lai C, Piao F, Lin M, Zhu S, Tian Z, Fu W, Dai Y, Yao C, Li G, Zheng Z, Meng X, Luo H.   +19 more
europepmc   +1 more source

Battling Congestion in HFpEF

JACC: Asia, 2022
Alex Pui-Wai Lee, Yiting Fan
openaire   +1 more source