Results 81 to 90 of about 37,898 (281)

Carnitine is a friend in HFpEF and foe in HFrEF

iScience
Heart failure (HF) is a global concern, particularly HF with preserved ejection fraction (HFpEF), lacking effective treatments. Understanding the differences of metabolic profiles between HFpEF and HFrEF (heart failure with reduced ejection fraction) patients is crucial for therapeutic advancements.
Huiqing Wang, Haoran Wei, Mingming Zhao, Junfang Wu, Min Fei, Nan Lin, Rui Zhan, Qingyuan Liu, Qi Zhang, Xiaodong Yao, Yufei Wu, Wenxin Shan, Hongtu Cui, Liang Ji, Bing Pan, Lu Fang, Yujie Zhu, Xin Li, Yansong Guo, Dao Wen Wang, Lemin Zheng   +20 more
openaire   +3 more sources

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

VDD-ICD Implantation in a Patient with Dextrocardia and Corrected Transposition of the Great Arteries

Cardiologia Hungarica
We present the case of a 52-year-old female patient on optimal medical therapy (OMT) for heart failure with severely reduced ejection fraction. She was diagnosed with dextrocardia and congenital corrected transposition of the great arteries (ccTGA) by ...
Krisztián István Kássa, Zoltán Som, Attila Kardos, Csaba Földesi   +3 more
doaj   +1 more source

The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence

Therapeutics and Clinical Risk Management, 2021
Manasvi Gupta,1 Shiavax Rao,2 Gaurav Manek,1 Gregg C Fonarow,3 Raktim K Ghosh4 1Department of Internal Medicine, University of Connecticut, Hartford, CT, USA; 2Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA; 3Department of ...
Gupta M, Rao S, Manek G, Fonarow GC, Ghosh RK   +4 more
doaj  

Effect of selective heart rate slowing in heart failure with preserved ejection fraction [PDF]

, 2015
Background Heart failure with preserved ejection fraction (HFpEF) is associated with significant morbidity and mortality but is currently refractory to therapy.
Ashrafian, Houman, Dawson, Dana K., Dwight, Jeremy S., Francis, Jane M., Frenneaux, Michael, Mahmod, Masliza, Neubauer, Stefan, Pal, Nikhil, Rudd, Amelia, Singh, Satnam, Sivaswamy, Nadiya, Watkins, Hugh, Yavari, Arash   +12 more
core   +2 more sources

Balloon‐Expandable Versus Self‐Expanding Valves in Bicuspid Aortic Stenosis: Insights From the SWEDEHEART Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter aortic valve replacement (TAVR) is increasingly used in patients with bicuspid aortic valve (BAV) stenosis, but there is limited comparative data on balloon‐expandable (BEV) versus self‐expanding valves (SEV) in this population. Aim To compare clinical and hemodynamic outcomes between BEVs and SEVs in patients with BAV
Antros Louca, Joakim Sundström, Araz Rawshani, Henrik Hagström, Magnus Settergren, Stefan James, Sasha Koul, Kristofer Skoglund, Dan Ioanes, Sebastian Völz, Anna Myredal, Oskar Angerås, Petur Petursson, Truls Råmunddal   +13 more
wiley   +1 more source

Advanced heart failure with reduced ejection fraction at a young age: how long can we wait?

Cardiologia Hungarica
The pharmacotherapy and device therapy for heart failure with reduced ejection fraction (HFrEF) have advanced considerably. However, there are instances where even with optimal therapy following the guidelines’ recommendations, some patients may require ...
Arnold Péter Ráduly, Zsófia Pólik, Ágnes Balogh, László Balogh, Kriszti Medvés-Váczi, Ágnes Rácz, Bertalan Kracskó, Zoltán Csanádi, Attila Borbély   +8 more
doaj   +1 more source

Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model

Health Technology Assessment, 2017
Background: Heart failure (HF) affects around 500,000 people in the UK. HF medications are frequently underprescribed and B-type natriuretic peptide (BNP)-guided therapy may help to optimise treatment.
Maria Pufulete, Rachel Maishman, Lucy Dabner, Syed Mohiuddin, William Hollingworth, Chris A Rogers, Julian Higgins, Mark Dayer, John Macleod, Sarah Purdy, Theresa McDonagh, Angus Nightingale, Rachael Williams, Barnaby C Reeves   +13 more
doaj   +1 more source

Inflammation-Based Scores as a Common Tool for Prognostic Assessment in Heart Failure or Cancer

Frontiers in Cardiovascular Medicine, 2021
Background: Inflammation-based scores are widely tested in cancer and have been evaluated in cardiovascular diseases including heart failure.Objectives: We investigated the impact of established inflammation-based scores on disease severity and survival ...
Henrike Arfsten, Anna Cho, Suriya Prausmüller, Georg Spinka, Johannes Novak, Georg Goliasch, Philipp E. Bartko, Markus Raderer, Heinz Gisslinger, Gabriela Kornek, Wolfgang Köstler, Guido Strunk, Matthias Preusser, Christian Hengstenberg, Martin Hülsmann, Noemi Pavo   +15 more
doaj   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar, Amna Rahman, Grace W.Y. Wong, Rajiv Sankaranarayanan, Fozia Z. Ahmed, Rebecca Taylor, Ahmet Fuat, Iain Squire, John G.F. Cleland, Gregory Y.H. Lip, James H.P. Gamble, Sundas Masudi, Prince Josiah S. Joseph, Kenneth Y.K. Wong   +13 more
wiley   +1 more source