Results 91 to 100 of about 13,128 (181)

Leveraging Quantitative Proteomics and Extracellular Vesicle Data to Uncover Druggable Receptor Kinases Across Cancers

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Extracellular vesicles (EVs) play an important role in cancer progression and metastasis. The increasing clinical proteomics data provides an opportunity to uncover new biomarkers and therapeutic targets in cancer specific EVs. Here, we present an integrated data analysis approach that leverages a comprehensive protein catalog from EVs, blood ...
Jina Kim, Su Yeon Yeon, Kyerim Choi, Hojung Kim, Hyoyoung Kim, Daehee Hwang, Sungyong You   +6 more
wiley   +1 more source

Derby database for mapping secondary to primary HGNC gene symbols

, 2022
Tooba Abbassi‐Daloii
openalex   +3 more sources

Minority Stress and Leukocyte Gene Expression In Sexual Minority Men Living With Treated HIV Infection [PDF]

, 2018
Sexual minority (i.e., non-heterosexual) individuals experience poorer mental and physical health, accounted for in part by the additional burden of sexual minority stress occurring from being situated in a culture favoring heteronormativity. Informed by
Aouizerat, Bradley E., Carrico, Adam W., Flentje, Annesa, Flowers, Elana, Heck, Nicholas C., Kober, Kord M., Neilands, Torsten B.   +6 more
core   +2 more sources

Unveiling the Immunopharmacological Mechanisms of Biejiajian Pills (BJJP) Underlying the Treatment of Hepatic Fibrosis: Insights From Network Pharmacology and Experimental Validation

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This study employed an integrated workflow combining network pharmacology, machine learning, molecular docking, UHPLC‐HRMS, and in vivo validation. The core design aimed to identify key compounds and signature genes of BJJP against HF, explore their immune‐related mechanisms, and verify the therapeutic targets and pathways through experimental ...
Chan Mo, Zhuolin Wei, Jinnan He, Yuan Liu, Jiaorong Zheng, Min Hong, Yuhong Song   +6 more
wiley   +1 more source

Protein Ontology: A controlled structured network of protein entities [PDF]

, 2013
The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level ...
Arighi Cecilia, N., Blake Judith, A., Bult Carol, J., Christie Karen, R., Diehl Alexander, D., Drabkin Harold, J., Julie, Cowart, Natale Darren, A., Olivia, Helfer, Others, Peter, D’Eustachio, Smith, Barry   +11 more
core  

Pharmacodynamics, Efficacy, and Safety of Intraputaminal Eladocagene Exuparvovec Administered to Pediatric Patients With Aromatic L‐Amino Acid Decarboxylase Deficiency Using an MR‐Compatible Cannula: 48 Weeks of Follow‐Up

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Aromatic ʟ‐amino acid decarboxylase (AADC) deficiency is a rare pediatric neurotransmitter disorder that typically necessitates lifelong care, and that carries a risk of childhood mortality. Eladocagene exuparvovec gene therapy is designed to restore AADC production.
Daniel J. Curry, Phillip L. Pearl, Scellig S. D. Stone, Donald L. Gilbert, Sudhakar Vadivelu, Bruria Ben‐Zeev, Matthew Vestal, Muhammad Zafar, Chun‐Hwei Tai, Sheng‐Che Chou, Zion Zibly, Lior Ungar, Mered Parnes, Mariam Hull, Lisa Emrick, Christian Werner, Alexis Krolick, Vinay Penematsa, Antonia Wang, Rezwanur Rahman, Lee Golden, Yin‐Hsiu Chien, Paul Wuh‐Liang Hwu   +22 more
wiley   +1 more source

Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels [PDF]

, 2015
Background: Geraniol (G) is a natural isoprenoid present in the essential oils of several aromatic plants, with various biochemical and pharmacologic properties.
Castro, Maria Agustina, Crespo, Rosana, Galle, Marianela Edith, García de Bravo, Margarita, Lacunza, Ezequiel, Montero Villegas, Sandra, Polo, Monica Patricia, Rodenak Kladniew, Boris Emilio   +7 more
core   +2 more sources

Folinic Acid Improves Healing of Diabetic Foot Ulcers

Wound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT A novel folinic acid (FA) wound treatment (FAWT) significantly (p < 0.05) improved healing (re‐epithelialization) of chronic diabetic foot ulcers (DFUs). In a double‐blind RCT, 10 (n = 10) chronic DFU subjects received daily topical treatment in either the Control group [(n = 5); PluroGel] or the FAWT group [(n = 5); PluroGel with FA 2.5 ...
Glenn D. Hoke, Annjanette Stone, Michael A. Bauer, Weleetka C. Carter, Megan R. Newsom, Joseph V. Boykin Jr.   +5 more
wiley   +1 more source

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. [PDF]

, 2014
© 2014 Haider et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Jemal, A Stathis, Ai Nagano, Aldo Scarpa, Ami Desai, AV Biankin, C Curtis, C Winter, Cancer Genome Atlas Research Network, CGA Network, Claude Chelala, CQ Zhu, D Cox, EA Collisson, F Maione, FM Buffa, G Zhang, H Huang, H Janouskova, H Pei, Hemant M Kocher, HH Wong, I Kovacevic, J Adachi, JA Tercero, JD Mosley, JK Stratford, John F Marshall, Jude Fitzgibbon, Jun Wang, K Yoshihara, L Badea, Laurent Dumartin, M Hidalgo, M Taniwaki, MA Tempero, MF Brennan, MM Al-Hawary, MW Muller, N Wasif, NF Li, Nicholas R Lemoine, NL Anderson, PA Perez-Mancera, PC Boutros, PG Febbo, PJ Campbell, Prabhu Arumugam, R Grutzmann, R Grutzmann, RR Plentz, S Jones, SJ Coleman, SV Srinivasan, Syed Haider, T Barrett, Tatjana Crnogorac-Jurcevic, Thorsten Hagemann, TR Donahue, VH Coupland   +59 more
core   +4 more sources

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source