Results 161 to 170 of about 2,707 (196)
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Managing high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands on prostate biopsy

Nature Reviews Urology, 2017
Prostate biopsy is the gold standard for diagnosing prostate cancer and reliable pathological assessment is essential for guiding management. Research efforts over the past few years have aimed to establish a more universal approach to management according to pathological grading; however, high-grade prostatic intraepithelial neoplasia (HGPIN) and ...
Jeffrey J, Tosoian   +4 more
openaire   +2 more sources

Management of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN)

2012
The diagnosis of isolated high-grade prostatic intraepithelial neoplasia (HGPIN) is based on findings of atypical nuclei in cells lining architecturally benign glands. This premalignant entity is associated with increased risk of coexistent cancer or delayed progression to carcinoma.
Krishna Ramaswamy   +2 more
openaire   +1 more source

Prognostic Significance of High-Grade Prostatic Intraepithelial Neoplasia (HGPIN): Risk of Prostatic Cancer on Repeat Biopsies

Urology, 2008
To verify prognostic significance of high-grade prostatic intraepithelial neoplasia (HGPIN) in 65 patients who underwent repeat biopsies with a mean follow-up of 36 months.In June 2007, after a retrospective revision of the biopsy reports that were performed between January 2002 and December 2006 because of prostate specific antigen (PSA) values ...
Fabrizio, Gallo   +4 more
openaire   +2 more sources

Randomized trial of toremifene to reduce high grade prostatic intraepithelial neoplasia (HGPIN) prior to radical prostatectomy (RP)

Journal of Clinical Oncology, 2007
5150 Background HGPIN may be a precursor lesion for prostate cancer (PCA). The selective estrogen-receptor modulator toremifene (TOR) has shown chemopreventive activity in preclinical models of PCA. The effect of TOR on HGPIN was studied in men with PCA prior to RP.
R. Day   +7 more
openaire   +1 more source

[A proteomic study of the serum proteins in BPH and HGPIN patients].

Zhonghua nan ke xue = National journal of andrology, 2008
To evaluate two-dimensional gel electrophoresis (2DGE) and mass spectrometry in the studies of the serum proteins expressed in patients with BPH and those with high-grade prostatic intraepithelial neoplasm (HGPIN).We extracted serum proteins from BPH and HGPIN patients by 2DGE and cut the differentially expressed interesting protein spots from the gel.
Xiao-Jian, Gu   +6 more
openaire   +1 more source

Effects of Soy Protein Isolate Consumption on Prostate Cancer Biomarkers in Men With HGPIN, ASAP, and Low-Grade Prostate Cancer

Nutrition and Cancer, 2007
Fifty-eight men at high risk of prostate cancer or with low-grade prostate cancer were randomly assigned to consume 1 of 3 protein isolates containing 40 g protein: 1) soy protein (SPI+, 107 mg isoflavones/d); 2) alcohol-washed soy protein (SPI-,
Jill M, Hamilton-Reeves   +4 more
openaire   +2 more sources

Abstract 3899: Genetic insights into clonal evolution from normal prostate epithelium to cancer via HGPIN

Cancer Research
Backgrounds: Prostate cancer (PC) is one of the most prevalent cancers in the developed world, where its incidence is still increasing. Most PCs are thought to arise from high-grade prostatic intraepithelial neoplasia (HGPIN), a well-recognized precursor lesion.
Kohsuke Hishiki   +9 more
openaire   +1 more source

117 Natural history of HGPIN and ASAP

European Urology Supplements, 2015
M. Barale   +14 more
openaire   +1 more source

Role of endorectal MR and MR-spectroscopy in patients with HGPIN and elevated PSA. Our experience.

2012
Purpose Methods and Materials Results Conclusion References Personal ...
openaire   +1 more source

Molecular Markers of Estrogen Metabolism and Progression From High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) to Prostate Cancer

2003
Abstract : The purpose of this case-control study is to investigate the association between genetic and endocrine markers of estrogen metabolism and prostate cancer progression. Androgens (e.g., testosterone) may be critical in prostate cancercinogenesis, but there is accumulating evidence that estrogens facilitate progress during the later stages of ...
Scott Shappell   +3 more
openaire   +1 more source

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