Results 121 to 130 of about 3,187 (152)

HHV-6A infection induces expression of HERV-K18-encoded superantigen

Journal of Clinical Virology, 2009
The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein-Barr virus (EBV) infection and IFN-alpha treatment.Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other
Albert K, Tai, Janos, Luka, Dharam, Ablashi, Brigitte T, Huber   +3 more
openaire   +2 more sources

PCR Analysis of Human Telomeric Repeats Present on HHV-6A Viral Strains

Virus Genes, 1997
Human herpesvirus 6 (HHV-6) presents a perfect tandem array of human telomeric repeats (TRS) at both identical direct repeats (DR). Several researchers have reported a different TRS copy number by sequence analysis of HHV-6 DR's cloned fragments so it has been hypothesized that number of TRS is unstable. By PCR we show that the TRS copy number of U1102
MIRANDOLA, Prisco, RAVAIOLI T., CASSAI E.   +2 more
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HHV-6A and HHV-6B in Autoimmune Disease

2014
A role for HHV-6 has been proposed in several autoimmune disorders (ADs), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. There are several potential mechanisms by which HHV-6 might induce autoimmune responses.
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AMPK restricts HHV-6A replication by inhibiting glycolysis and mTOR signaling

Virology
AMP-activated protein kinase (AMPK) is a cellular energy sensor regulating metabolic homeostasis. In this study, we investigated the role of AMPK in response to human herpesvirus 6A (HHV-6A) infection. We show that HHV-6A infection significantly downregulates the active phosphorylated state of AMPK in infected T cells.
Xiaodi, Yang, Siyu, Tian, Zhujiang, Min, Emanuela, Garbarino, Jingjing, Ma, Junli, Jia, Huamin, Tang, Lingyun, Li   +7 more
openaire   +2 more sources

HHV-6A, 6B, and 7: molecular basis of latency and reactivation

2007
The human β-herpesvirus subfamily consists of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), and human herpesvirus 7 (HHV-7). HHV-6 and HHV-7 belong to the Roseolovirus genus of the β-herpesviruses, and the HHV-6 species are divided into two variants: HHV-6A and HHV-6B.
Kazuhiro Kondo, Koichi Yamanishi
openaire   +1 more source

HHV-6A, 6B, and 7: persistence in the population: epidemiology and transmission

2007
In common with all human herpesviruses, HHV-6 and HHV-7 establish lifelong infection following initial exposure and seroconversion. True latency as exemplified by HSV-1 and VZV, in which the genome is maintained in a transcriptionally restricted state, has not been conclusively shown for HHV-6 or HHV-7.
Vincent C. Emery, Duncan A. Clark
openaire   +1 more source

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution

Journal of Virology
ABSTRACT Despite the availability of bacterial artificial chromosome (BAC) systems for human herpesvirus 6A (HHV-6A), reconstitution of infectious viruses is very challenging and time consuming. In this study, we developed approaches to improve the reconstitution process and enhance virus replication to overcome ...
Jana Reich, Dilan Serdar, Ann-Christin Weißmann, Benedikt B. Kaufer   +3 more
openaire   +2 more sources

HHV-6A, 6B, and 7: pathogenesis, host response, and clinical disease

2007
Human herpesvirus 6(HHV-6) is a human pathogen of emerging clinical significance. HHV-6 was first isolated from patients with lymphoproliferative disorders in 1986 (Salahuddin et al., 1986). HHV-6 isolates are classified into two groups as variants A(HHV-6A) and variant B(HHV-6B) (Schirmer et al., .
Yasuko Mori, Koichi Yamanishi
openaire   +1 more source

24: IgG avidity for HHV-6A and HHV-6B

Journal of Clinical Virology, 2006
J.O. Virtanen, A. Vaheri, M. Koskiniemi
openaire   +1 more source

Role of P2X7 polymorphisms in idiopathic infertility and HHV-6A infection

2017
P2X7 receptor is an ATP gated ion channel well known for its pro-inflammatory, anti-infectious activity. The human gene for P2X7 receptor is highly polymorphic accounting for more than 1500 SNPs, among which ten loss and three gain of function variants.
Anna Pegoraro, Daria Bortolotti, Mariangela Sicolo, Elisabetta Caselli, Dario Di Luca, Francesco Di Virgilio, Roberto Marci, Roberta Rizzo, Elena Adinolfi   +8 more
openaire   +1 more source