Results 1 to 10 of about 66,683 (210)

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

Frontiers in Immunology, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos   +7 more
doaj   +8 more sources

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis [PDF]

Frontiers in Immunology
BackgroundHuman herpesvirus 6B (HHV-6B) is associated with various central nervous system (CNS) disorders, particularly in immunocompromised patients. We present a rare case of inherited chromosomally integrated HHV-6B (iciHHV-6B), also referred to as ...
Scott Sun, Scott Sun, Konstance Knox, Alexander Romashko, Madhu Kundu, Haiying Zhu, Meei-Li Huang, Denise M. Malicki, Denise M. Malicki, John R. Crawford, John R. Crawford, John R. Crawford   +11 more
doaj   +6 more sources

Characterization of the HHV-6B U20 Immunoevasin. [PDF]

J Virol, 2023
The roseolovirus U20 proteins are virus-encoded integral membrane glycoproteins possessing class I major histocompatibility complex (MHC)-like folds.
Schneider CL, Whyte ML, Konrad SL, Hudson AW.   +3 more
europepmc   +4 more sources

HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant [PDF]

Nature Communications
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT).
Joshua A. Hill, Yeon Joo Lee, Lisa K. Vande Vusse, Hu Xie, E. Lisa Chung, Alpana Waghmare, Guang-Shing Cheng, Haiying Zhu, Meei-Li Huang, Geoffrey R. Hill, Keith R. Jerome, Wendy M. Leisenring, Danielle M. Zerr, Sina A. Gharib, Sanjeet Dadwal, Michael Boeckh   +15 more
doaj   +4 more sources

Uncovering the Cause of Pneumonia: Reactivation of HHV-6B in an Immunocompromised Patient. [PDF]

Eur J Case Rep Intern Med
Human herpesvirus 6 (HHV-6) is a ubiquitous virus that commonly infects the paediatric population and establishes latency in the host following primary infection.
Rodrigues L, Nogueira J, Alves D, Ferreira F, Fonseca J.   +4 more
europepmc   +4 more sources

Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. [PDF]

Open Forum Infect Dis
Background Human herpesvirus 6B (HHV-6B) frequently reactivates following allogeneic stem cell transplant (alloHCT). Consensus guidelines note that haploidentical alloHCT may represent a high-risk population for which there is little evidence; this ...
Handley G, Yepes A, Eliassen E, Dominguez G, Pasikhova Y, Klinkova O, Baluch A, Febres-Aldana AJ, Alsina M, Elmariah H, Khimani F, Hansen DK, Freeman CL, Jain MD, Locke F, Lazaryan A, Liu HD, Mishra A, Mirza AS, Nishihori T, Ochoa L, Perez L, Pidala J, Puglianini OC, Nieder M, Perna F, Kim J, Bejanyan N, Faramand R.   +28 more
europepmc   +4 more sources

HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Bone marrow hematopoietic stem cell transplantation (BMT) is one of the most effective treatments for hematological malignancies, and cord blood hematopoietic stem cell transplantation is one of them [1].
Xu B, Jia Y, Lv L, Chen L, Cheng P, Ren S, Liu H, Zhang M, Zhang H.   +8 more
europepmc   +3 more sources

Persistent viremia in an immunocompetent patient with inherited chromosomally integrated HHV-6B. [PDF]

Access Microbiol, 2021
Human herpesvirus-6 (HHV-6), the virus which causes roseola, has traditionally been associated with benign and self-limited childhood illness. However, HHV-6 establishes lifelong latency and can reactivate in immunocompromised adult patients. In about 1%
Obeid M, Gakhal I, McDonald PJ.
europepmc   +4 more sources

Oral brincidofovir decreases the incidence of HHV-6B viremia after allogeneic HCT. [PDF]

Blood, 2020
Human herpesvirus 6B (HHV-6B) frequently reactivates after allogeneic hematopoietic cell transplantation (HCT). There are no randomized studies of antiviral treatments to prevent HHV-6B reactivation.
Hill JA, Nichols WG, Marty FM, Papanicolaou GA, Brundage TM, Lanier R, Zerr DM, Boeckh MJ.   +7 more
europepmc   +4 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections [PDF]

Journal of Virology, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and
Zhisheng Wu, Huamin Tang
exaly   +3 more sources