Results 1 to 10 of about 78,725 (202)

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

Frontiers in Immunology, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos   +7 more
doaj   +11 more sources

HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant [PDF]

Nature Communications
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT).
Joshua A. Hill, Yeon Joo Lee, Lisa K. Vande Vusse, Hu Xie, E. Lisa Chung, Alpana Waghmare, Guang-Shing Cheng, Haiying Zhu, Meei-Li Huang, Geoffrey R. Hill, Keith R. Jerome, Wendy M. Leisenring, Danielle M. Zerr, Sina A. Gharib, Sanjeet Dadwal, Michael Boeckh   +15 more
doaj   +5 more sources

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B [PDF]

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +6 more sources

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis [PDF]

Frontiers in Immunology
BackgroundHuman herpesvirus 6B (HHV-6B) is associated with various central nervous system (CNS) disorders, particularly in immunocompromised patients. We present a rare case of inherited chromosomally integrated HHV-6B (iciHHV-6B), also referred to as ...
Scott Sun, Scott Sun, Konstance Knox, Alexander Romashko, Madhu Kundu, Haiying Zhu, Meei-Li Huang, Denise M. Malicki, Denise M. Malicki, John R. Crawford, John R. Crawford, John R. Crawford   +11 more
doaj   +6 more sources

DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]

Frontiers in Microbiology, 2020
ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti, Valentina Gentili, Elisabetta Caselli, Mariangela Sicolo, Irene Soffritti, Maria D’Accolti, Isabel Barao, Isabel Barao, Antonella Rotola, Dario Di Luca, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +4 more sources

The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation [PDF]

Frontiers in Immunology
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver, Grant C. Weaver, Christine L. Schneider, Aniuska Becerra-Artiles, Kiera L. Clayton, Kiera L. Clayton, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +9 more
doaj   +5 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]

Journal of Virology, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and
Zhisheng Wu, Huamin Tang, Junli Jia
exaly   +3 more sources

Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress

Journal of General Virology, 2019
Herpesviruses are known to manipulate autophagy to optimize their replication, counteract immune response and probably to promote tumourigenesis.
Laura MASUELLI, Maria Saveria Gilardini Montani, Aurelia Gaeta   +2 more
exaly   +3 more sources

Hippocampal Atrophy in Pediatric Transplant Recipients with Human Herpesvirus 6B

Microorganisms, 2021
The aim of this study was to determine whether human herpesvirus 6B (HHV-6B) infection can impair the hippocampus in pediatric hematopoietic stem cell transplant (HSCT) recipients.
Misa Miyake, Yoshiki Kawamura, Naoko Ishihara, Shigetaka Suzuki, Hiroki Miura, Yoko Sakaguchi, Masaharu Tanaka, Yoshiyuki Takahashi, Seiji Kojima, Hiroshi Toyama, Jun Natsume, Tetsushi Yoshikawa   +11 more
doaj   +1 more source

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

mBio, 2021
HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood.
Xuefeng Jiang, Tian Tang, Jinfeng Guo, Yuhang Wang, Peipei Li, Xiangjun Chen, Lily Wang, Yiqun Wen, Junli Jia, Garbarino Emanuela, Benshun Hu, Shuhua Chen, Kun Yao, Linyun Li, Huaming Tang   +14 more
doaj   +1 more source