Results 1 to 10 of about 44,824 (211)

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

Frontiers in Immunology, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos   +7 more
doaj   +11 more sources

HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant [PDF]

Nature Communications
Limited understanding of the immunopathogenesis of human herpesvirus 6B (HHV-6B) has prevented its acceptance as a pulmonary pathogen after hematopoietic cell transplant (HCT).
Joshua A. Hill, Yeon Joo Lee, Lisa K. Vande Vusse, Hu Xie, E. Lisa Chung, Alpana Waghmare, Guang-Shing Cheng, Haiying Zhu, Meei-Li Huang, Geoffrey R. Hill, Keith R. Jerome, Wendy M. Leisenring, Danielle M. Zerr, Sina A. Gharib, Sanjeet Dadwal, Michael Boeckh   +15 more
doaj   +5 more sources

DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]

Frontiers in Microbiology, 2020
ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti, Valentina Gentili, Elisabetta Caselli, Mariangela Sicolo, Irene Soffritti, Maria D’Accolti, Isabel Barao, Isabel Barao, Antonella Rotola, Dario Di Luca, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +6 more sources

The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation [PDF]

Frontiers in Immunology
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver, Grant C. Weaver, Christine L. Schneider, Aniuska Becerra-Artiles, Kiera L. Clayton, Kiera L. Clayton, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +9 more
doaj   +6 more sources

Characterization of the HHV-6B U20 Immunoevasin. [PDF]

J Virol, 2023
The roseolovirus U20 proteins are virus-encoded integral membrane glycoproteins possessing class I major histocompatibility complex (MHC)-like folds.
Schneider CL, Whyte ML, Konrad SL, Hudson AW.   +3 more
europepmc   +4 more sources

Case Report: Inherited chromosomally integrated HHV-6B in a pediatric medulloblastoma patient with encephalitis [PDF]

Frontiers in Immunology
BackgroundHuman herpesvirus 6B (HHV-6B) is associated with various central nervous system (CNS) disorders, particularly in immunocompromised patients. We present a rare case of inherited chromosomally integrated HHV-6B (iciHHV-6B), also referred to as ...
Scott Sun, Scott Sun, Konstance Knox, Alexander Romashko, Madhu Kundu, Haiying Zhu, Meei-Li Huang, Denise M. Malicki, Denise M. Malicki, John R. Crawford, John R. Crawford, John R. Crawford   +11 more
doaj   +3 more sources

HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Bone marrow hematopoietic stem cell transplantation (BMT) is one of the most effective treatments for hematological malignancies, and cord blood hematopoietic stem cell transplantation is one of them [1].
Xu B, Jia Y, Lv L, Chen L, Cheng P, Ren S, Liu H, Zhang M, Zhang H.   +8 more
europepmc   +3 more sources

Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production [PDF]

Journal of Virology
Human herpesvirus 6B (HHV-6B), a member of the Betaherpesvirinae subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis.
Haokun Li, Hirohito Ogawa, Da Teng, Yuki Okame, Hikaru Namba, Tomoyuki Honda   +5 more
doaj   +5 more sources

HHV-6B- and HHV-7-associated choroiditis secondary to acute myelogenous leukemia: a case report. [PDF]

J Int Med Res, 2023
We report a case of human herpes virus 6 (HHV-6)- and human herpes virus 7 (HHV-7)-associated choroiditis in an immunocompromised woman. A 42-year-old Chinese woman with a history of acute myelogenous leukemia presented with blurred vision and black ...
Xu J, Chen L, Cen T, Zeng Y, Liu Q.
europepmc   +2 more sources

Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7. [PDF]

Front Immunol, 2022
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins.
Weaver GC, Arya R, Schneider CL, Hudson AW, Stern LJ.   +4 more
europepmc   +2 more sources