Results 1 to 10 of about 35,145 (190)

Classification of HHV-6A and HHV-6B as distinct viruses. [PDF]

Arch Virol, 2014
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-
Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T.   +20 more
europepmc   +8 more sources

Outcomes of Haploidentical Stem Cell Transplant Recipients With HHV-6B Reactivation. [PDF]

Open Forum Infect Dis
Abstract Background Human herpesvirus 6B (HHV-6B) frequently reactivates following allogeneic stem cell transplant (alloHCT). Consensus guidelines note that haploidentical alloHCT may represent a high-risk population for which there is little evidence; this warrants further investigation.
Handley G, Yepes A, Eliassen E, Dominguez G, Pasikhova Y, Klinkova O, Baluch A, Febres-Aldana AJ, Alsina M, Elmariah H, Khimani F, Hansen DK, Freeman CL, Jain MD, Locke F, Lazaryan A, Liu HD, Mishra A, Mirza AS, Nishihori T, Ochoa L, Perez L, Pidala J, Puglianini OC, Nieder M, Perna F, Kim J, Bejanyan N, Faramand R.   +28 more
europepmc   +3 more sources

Oral brincidofovir decreases the incidence of HHV-6B viremia after allogeneic HCT. [PDF]

Blood, 2020
Abstract Human herpesvirus 6B (HHV-6B) frequently reactivates after allogeneic hematopoietic cell transplantation (HCT). There are no randomized studies of antiviral treatments to prevent HHV-6B reactivation. Brincidofovir has high in vitro activity against HHV-6B and other DNA viruses, but its in vivo activity for HHV-6B has not been ...
Hill JA, Nichols WG, Marty FM, Papanicolaou GA, Brundage TM, Lanier R, Zerr DM, Boeckh MJ.   +7 more
europepmc   +3 more sources

Role of HHV-6B Infection in Mesial Temporal Lobe Epilepsy. [PDF]

Pediatr Neurol Briefs, 2015
Investigators from Fujita Health University, Toyoake, and National Epilepsy Center, Shizuoka, Japan, studied the pathogenic role of HHV-6B in patients with mesial temporal lobe epilepsy (MTLE).
Millichap JJ, Millichap JG.
europepmc   +6 more sources

Retraction to: A complex evolutionary relationship between HHV-6A and HHV-6B. [PDF]

Virus Evol, 2019
[This retracts the article DOI: 10.1093/ve/vez043.].
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +4 more sources

Evaluation of a method to measure HHV-6B infection in vitro based on cell size. [PDF]

Virol J, 2018
Human herpesvirus 6 (HHV-6A and HHV-6B) infection of cell cultures can be measured by different methods, including immunofluorescence microscopy, flow cytometry, or quantification of virus DNA by qPCR. These methods are reliable and sensitive but require long processing times and can be costly.
Becerra-Artiles A, Santoro T, Stern LJ.
europepmc   +6 more sources

The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation [PDF]

Frontiers in Immunology
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver, Grant C. Weaver, Christine L. Schneider, Aniuska Becerra-Artiles, Kiera L. Clayton, Kiera L. Clayton, Amy W. Hudson, Lawrence J. Stern, Lawrence J. Stern, Lawrence J. Stern   +9 more
doaj   +2 more sources

Clinical and epidemiological features of infections caused by HHV-6A and HHV-6B [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Objective. To determine the detection rates of HHV-6A and HHV-6B compared to other herpes viruses in children of different age groups. Materials and Methods.
Lysenkova M.Yu., Karazhas N.V., Rybalkina T.N., Veselovsky P.A., Burmistrov E.M., Boshyan R.E., Melekhina E.V., Svitich O.A., Muzyka A.D., Petukhova E.V., Gorelov A.V.   +10 more
doaj   +3 more sources

A complex evolutionary relationship between HHV-6A and HHV-6B.

Virus Evol, 2019
Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6, iciHHV6). We reconstructed the population structure of HHV-6 and we show that HHV-6A genomes
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +3 more sources

HHV-6B infection after umbilical cord blood stem cell transplantation with pruritus as the first symptom. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Xu B, Jia Y, Lv L, Chen L, Cheng P, Ren S, Liu H, Zhang M, Zhang H.   +8 more
europepmc   +2 more sources