Persistent viremia in an immunocompetent patient with inherited chromosomally integrated HHV-6B. [PDF]
Access Microbiol, 2021 Human herpesvirus-6 (HHV-6), the virus which causes roseola, has traditionally been associated with benign and self-limited childhood illness. However, HHV-6 establishes lifelong latency and can reactivate in immunocompromised adult patients. In about 1% of cases, it integrates into the human genome as inherited chromosomally integrated HHV-6 (iciHHV-6)
Obeid M, Gakhal I, McDonald PJ.
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HHV-6B- and HHV-7-associated choroiditis secondary to acute myelogenous leukemia: a case report [PDF]
J Int Med Res, 2023 We report a case of human herpes virus 6 (HHV-6)- and human herpes virus 7 (HHV-7)-associated choroiditis in an immunocompromised woman. A 42-year-old Chinese woman with a history of acute myelogenous leukemia presented with blurred vision and black ...
Jing Xu +4 more
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TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV [PDF]
Front ImmunolBackground The role of CD4 T cells in the control of viral infections beyond their traditional helper activity has been increasingly recognized, and CD4 T cells with cytotoxic capacity have been reported for the nearly ubiquitous betaherpesviruses HCMV ...
Aniuska Becerra-Artiles +3 more
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Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7 [PDF]
Front Immunol, 2022 Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins.
Grant C Weaver +4 more
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Donepezil ameliorates fatigue and depression in PASC patients with HHV-6B SITH-1-induced acetylcholine deficiency [PDF]
Front PharmacolIntroduction The pathogenesis of post-acute sequelae of SARS-CoV-2 infection (PASC) remains poorly understood, and no effective treatment has been established.
Naomi Oka +9 more
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American Society for Transplantation and Cellular Therapy Series #9: Management of HHV-6B After Hematopoietic Cell Transplantation and Chimeric Antigen Receptor (CAR)-T-Cell Therapy [PDF]
Transplant Cell TherThe Practice Guidelines Committee and the Transplant Infectious Disease Special Interest Group of the American Society for Transplantation and Cellular Therapy developed guidelines focusing on human herpes virus 6B (HHV-6B).
E. Kampouri +12 more
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Role of HHV-6B Infection in Mesial Temporal Lobe Epilepsy. [PDF]
Pediatr Neurol Briefs, 2015 Investigators from Fujita Health University, Toyoake, and National Epilepsy Center, Shizuoka, Japan, studied the pathogenic role of HHV-6B in patients with mesial temporal lobe epilepsy (MTLE).
Millichap JJ, Millichap JG.
europepmc +6 more sources
A Patient-Derived iPSC-Based Model Reveals Neural Lineage-Specific Transcription of Endogenous HHV-6B [PDF]
J Infect DisBackground Endogenous human herpesvirus 6 (eHHV-6), in which the entire viral genome is integrated into human chromosomes, is present in approximately 1% of the population and has been associated with various clinical conditions, including neurological ...
Hiroki Miura +13 more
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Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay. [PDF]
PLoS ONE, 2014 The human herpesviruses HHV-6A and HHV-6B have been associated with various neurologic disorders partly due to the detection of elevated viral DNA levels in patients compared to controls.
Emily C Leibovitch +6 more
doaj +2 more sources
2094. A prospective multicenter study of HHV-6B genomic DNA and gene transcription in paired bronchoalveolar lavage fluid and blood from HCT recipients [PDF]
Open Forum Infect Dis, 2022 Background We previously demonstrated frequent detection of HHV-6B DNA in bronchoalveolar lavage fluid (BALF) and its positive association with mortality in HCT recipients from 1992-2015 with lower respiratory tract disease (LRTD). Whether these findings
J. Hill +16 more
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