Results 1 to 10 of about 40,457 (178)

HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B [PDF]

Viruses, 2017
Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of ...
Vanessa Collin, Louis Flamand
doaj   +7 more sources

High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort [PDF]

Frontiers in Transplantation, 2023
Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase
Arturo Blazquez-Navarro, Arturo Blazquez-Navarro, Toralf Roch, Toralf Roch, Patrizia Wehler, Patrizia Wehler, Sviatlana Kaliszczyk, Sviatlana Kaliszczyk, Chris Bauer, Constantin Thieme, Kamil S. Rosiewicz, Ulrik Stervbo, Ulrik Stervbo, Moritz Anft, Petra Reinke, Christian Hugo, Panagiota Zgoura, Richard Viebahn, Timm Westhoff, Michal Or-Guil, Nina Babel, Nina Babel   +21 more
doaj   +7 more sources

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani, Cosima Zimmerman, Princess Rodriguez, Ellie Hasenohr, Giulia Aimola, Diana Lea Gerrard, Alyssa Richman, Andrea Dest, Louis Flamand, Benedikt Kaufer, Seth Frietze, Seth Frietze   +11 more
doaj   +8 more sources

Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells [PDF]

Frontiers in Immunology, 2022
Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian, Elham Bahramian, Mercede Furr, Jerry T. Wu, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos, Ruben Michael Ceballos   +7 more
doaj   +10 more sources

The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition [PDF]

Frontiers in Immunology, 2021
The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat, Barbara Seliger, Barbara Seliger, Ofer Mandelboim, Dominik Schmiedel, Dominik Schmiedel   +5 more
doaj   +7 more sources

DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]

Frontiers in Microbiology, 2020
ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti, Valentina Gentili, Elisabetta Caselli, Mariangela Sicolo, Irene Soffritti, Maria D’Accolti, Isabel Barao, Isabel Barao, Antonella Rotola, Dario Di Luca, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +4 more sources

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B [PDF]

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +4 more sources

The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]

PLoS Pathogens, 2016
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek, Anirban Sanyal, Fabian Pirzer, Annie Gravel, Yasuko Mori, Louis Flamand, Benedikt B Kaufer   +6 more
doaj   +5 more sources

HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity [PDF]

Frontiers in Microbiology, 2017
Background: We have recently reported the presence of Human herpesvirus-6A (HHV-6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women.
Elisabetta Caselli, Daria Bortolotti, Roberto Marci, Antonella Rotola, Valentina Gentili, Irene Soffritti, Maria D’Accolti, Giuseppe Lo Monte, Mariangela Sicolo, Isabel Barao, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +5 more sources

The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility [PDF]

Frontiers in Pharmacology, 2020
The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom ...
Anna Pegoraro, Daria Bortolotti, Roberto Marci, Roberto Marci, Elisabetta Caselli, Simonetta Falzoni, Elena De Marchi, Francesco Di Virgilio, Roberta Rizzo, Elena Adinolfi   +9 more
doaj   +2 more sources