Chromosomal integration of HHV-6A during non-productive viral infection [PDF]
Scientific Reports, 2017 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported.
Nitish Gulve +3 more
doaj +7 more sources
HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity [PDF]
Frontiers in Microbiology, 2017 Background: We have recently reported the presence of Human herpesvirus-6A (HHV-6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women.
Elisabetta Caselli +11 more
doaj +8 more sources
Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility. [PDF]
PLoS ONE, 2016 To elucidate the roles of human herpesvirus (HHV)-6 primary unexplained infertile women, a prospective randomized study was conducted on a cohort of primary unexplained infertile women and a cohort of control women, with at least one successful pregnancy.
Roberto Marci +8 more
doaj +7 more sources
Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations. [PDF]
Virus Evol, 2020 Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated
Forni D +4 more
europepmc +7 more sources
gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]
J Virol, 2020 Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and
Ma J +11 more
europepmc +5 more sources
SARS-CoV-2 Infection Associated with HHV-6A Reactivation and an Inhibitory KIR2DL2/HLA-C1 Immunogenetic Profile [PDF]
MicroorganismsNatural killer (NK) cells are central to antiviral immunity through a balance of activating and inhibitory receptors, including killer immunoglobulin-like receptors (KIRs).
Sabrina Rizzo +8 more
doaj +3 more sources
HHV-6A Infection of Endometrial Epithelial Cells Affects miRNA Expression and Trophoblast Cell Attachment. [PDF]
Reprod Sci, 2020 We recently reported that human herpesvirus 6 (HHV-6) infection is frequently present in endometrial tissue of women with unexplained infertility, and that virus infection induces a profound remodulation of miRNA expression in human cells of different ...
Bortolotti D +6 more
europepmc +5 more sources
Herpes viral infection and the multiple sclerosis prodrome: is HHV-6A infection a second hit? [PDF]
Brain, 2023 This scientific commentary refers to ‘Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis’ by Grut et al. (https://doi.org/10.1093/brain/awad374).
Cree BAC.
europepmc +2 more sources
HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression. [PDF]
Viruses, 2023 Recent studies have shown that thyrocytes are permissive to HHV-6A infection and that the virus may contribute to the pathogenesis of autoimmune thyroiditis.
Mardente S +5 more
europepmc +2 more sources
The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated. [PDF]
Genes (Basel), 2023 Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DRR) region.
Kusakin AV +11 more
europepmc +2 more sources