The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration. [PDF]
PLoS Pathogens, 2016 Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types.
Nina Wallaschek +6 more
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Human herpesvirus-6A/B binds to spermatozoa acrosome and is the most prevalent herpesvirus in semen from sperm donors. [PDF]
PLoS ONE, 2012 An analysis of all known human herpesviruses has not previously been reported on sperm from normal donors. Using an array-based detection method, we determined the cross-sectional frequency of human herpesviruses in semen from 198 Danish sperm donors ...
Maja D Kaspersen +5 more
doaj +6 more sources
Increased Serological Response Against Human Herpesvirus 6A Is Associated With Risk for Multiple Sclerosis [PDF]
Frontiers in Immunology, 2019 Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish the two viruses.
Elin Engdahl +37 more
doaj +4 more sources
Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration [PDF]
Scientific Reports, 2017 Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs).
Andrew Campbell +6 more
doaj +4 more sources
The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome [PDF]
Viruses, 2018 Human herpesvirus 6A (HHV-6A) replicates in peripheral blood mononuclear cells (PBMCs) and various T-cell lines in vitro. Intriguingly, the virus can also establish latency in these cells, but it remains unknown what influences the decision between lytic
Anirban Sanyal +5 more
doaj +4 more sources
Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. [PDF]
PLoS ONE, 2013 Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the ...
Rasmus K L Gustafsson +7 more
doaj +2 more sources
Human herpesvirus 6A promotes glycolysis in infected T cells by activation of mTOR signaling. [PDF]
PLoS Pathogens, 2020 Human herpesvirus 6 (HHV-6) is an important immunosuppressive and immunomodulatory virus worldwide. However, whether and how HHV-6 infection influences the metabolic machinery of the host cell to provide the energy and biosynthetic resources for virus ...
Zhisheng Wu +10 more
doaj +2 more sources
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +1 more source
Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites
Frontiers in Cellular and Infection Microbiology, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani +11 more
doaj +1 more source
Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. [PDF]
PLoS ONE, 2009 The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53.
Mariane H Schleimann +3 more
doaj +1 more source