Results 31 to 40 of about 125,465 (162)

Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection [PDF]

Viruses, 2016
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”.
Joshua Tweedy, Maria Alexandra Spyrou, Max Pearson, Dirk Lassner, Uwe Kuhl, Ursula A. Gompels   +5 more
doaj   +2 more sources

Complexities in human herpesvirus-6A and -6B binding to host cells

Virology, 2006
Human herpesvirus-6A and -6B uses the cellular receptor CD46 for fusion and infection of the host cell. The viral glycoprotein complex gH–gL from HHV-6A binds to the short consensus repeat 2 and 3 in CD46. Although all the major isoforms of CD46 bind the
Pedersen, Simon Metz, Höllsberg, Per
core   +4 more sources

Human Herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of Human Leukocyte Antigen G. [PDF]

Sci Rep, 2018
We have previously reported that human herpesvirus 6 (HHV-6) infection of endothelial cells (ECs) induces the loss of angiogenic properties, through the expression of HHV-6 U94, possibly associated to the release of a soluble mediator.
Rizzo R, D'Accolti M, Bortolotti D, Caccuri F, Caruso A, Di Luca D, Caselli E.   +6 more
europepmc   +8 more sources

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways [PDF]

Virology Journal, 2011
Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous
Gu Bin, Zhang Guo-Feng, Li Ling-Yun, Zhou Feng, Feng Dong-Ju, Ding Chuan-Lin, Chi Jing, Zhang Chun, Guo Dan-Dan, Wang Jing-Feng, Zhou Hong, Yao Kun, Hu Wei-Xing   +12 more
doaj   +2 more sources

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. [PDF]

Microbiol Spectr, 2023
Human herpesvirus 6 (HHV-6) infects almost all humans and integrates into the telomeres of latently infected cells to persist in the host for life. In addition, HHV-6 can also integrate into the telomeres of germ cells, which results in about 80 million individuals worldwide who carry the virus in every cell of their body and can pass it on to their ...
Aimola G, Wight DJ, Flamand L, Kaufer BB.   +3 more
europepmc   +3 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]

J Virol, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Ma J, Jia J, Jiang X, Xu M, Guo J, Tang T, Xu X, Wu Z, Hu B, Yao K, Li L, Tang H.   +11 more
europepmc   +4 more sources

Epstein-Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis. [PDF]

Eur J Neurol, 2021
Background and purpose: Infections with human herpesvirus 6A (HHV-6A) and Epstein–Barr virus (EBV) have been linked to multiple sclerosis (MS) development.
Biström M, Jons D, Engdahl E, Gustafsson R, Huang J, Brenner N, Butt J, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bender N, Waterboer T, Granåsen G, Olsson T, Kockum I, Andersen O, Fogdell-Hahn A, Sundström P.   +17 more
europepmc   +2 more sources

Human Herpesvirus 6A U4 Inhibits Proteasomal Degradation of the Amyloid Precursor Protein. [PDF]

J Virol, 2022
The association of HHV-6A infection with Alzheimer’s disease has attracted increasing attention, although its role and molecular mechanism remain to be established. Our results here indicate that HHV-6A U4 inhibits amyloid precursor protein (APP) degradation.
Tang T, Jia J, Garbarino E, Chen L, Ma J, Li P, Chen X, Wang L, Wen Y, Wang Y, Li L, Yao K, Tang H.   +12 more
europepmc   +3 more sources

ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. [PDF]

J Virol, 2022
Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction.
Aktar S, Arii J, Nguyen TTH, Huang JR, Nishimura M, Mori Y.   +5 more
europepmc   +3 more sources

Human Herpesvirus 6A (HHV-6A) Encephalitis in an Immunocompetent Patient and Its Association With Glioblastoma: A Case Report. [PDF]

Cureus
Human herpesvirus 6 (HHV-6) is a neurotropic virus capable of establishing latency in the central nervous system. While its reactivation is well-documented in immunocompromised individuals, its role in immunocompetent hosts remains unclear. Additionally, growing but inconclusive evidence suggests a potential association between HHV-6 and glioblastoma ...
Aleixo R, Sá R, Ramos I, Valente C.
europepmc   +3 more sources