Results 31 to 40 of about 7,974,842 (159)

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways [PDF]

Virology Journal, 2011
Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous
Gu Bin, Zhang Guo-Feng, Li Ling-Yun, Zhou Feng, Feng Dong-Ju, Ding Chuan-Lin, Chi Jing, Zhang Chun, Guo Dan-Dan, Wang Jing-Feng, Zhou Hong, Yao Kun, Hu Wei-Xing   +12 more
doaj   +2 more sources

Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. [PDF]

Microbiol Spectr, 2023
Human herpesvirus 6 (HHV-6) infects almost all humans and integrates into the telomeres of latently infected cells to persist in the host for life. In addition, HHV-6 can also integrate into the telomeres of germ cells, which results in about 80 million individuals worldwide who carry the virus in every cell of their body and can pass it on to their ...
Aimola G, Wight DJ, Flamand L, Kaufer BB.   +3 more
europepmc   +3 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]

J Virol, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Ma J, Jia J, Jiang X, Xu M, Guo J, Tang T, Xu X, Wu Z, Hu B, Yao K, Li L, Tang H.   +11 more
europepmc   +4 more sources

Epstein-Barr virus infection after adolescence and human herpesvirus 6A as risk factors for multiple sclerosis. [PDF]

Eur J Neurol, 2021
Background and purpose: Infections with human herpesvirus 6A (HHV-6A) and Epstein–Barr virus (EBV) have been linked to multiple sclerosis (MS) development.
Biström M, Jons D, Engdahl E, Gustafsson R, Huang J, Brenner N, Butt J, Alonso-Magdalena L, Gunnarsson M, Vrethem M, Bender N, Waterboer T, Granåsen G, Olsson T, Kockum I, Andersen O, Fogdell-Hahn A, Sundström P.   +17 more
europepmc   +2 more sources

Human herpesvirus 6A nuclear matrix protein U37 interacts with heat shock transcription factor 1 and activates the heat shock response. [PDF]

J Virol, 2023
Nascent nucleocapsids of herpesviruses acquire a primary envelope during their nuclear export by budding through the inner nuclear membrane into the perinuclear space between the inner and outer nuclear membranes.
Huang JR, Arii J, Hirai M, Nishimura M, Mori Y.   +4 more
europepmc   +2 more sources

Human Herpesvirus 6A U4 Inhibits Proteasomal Degradation of the Amyloid Precursor Protein. [PDF]

J Virol, 2022
The association of HHV-6A infection with Alzheimer’s disease has attracted increasing attention, although its role and molecular mechanism remain to be established. Our results here indicate that HHV-6A U4 inhibits amyloid precursor protein (APP) degradation.
Tang T, Jia J, Garbarino E, Chen L, Ma J, Li P, Chen X, Wang L, Wen Y, Wang Y, Li L, Yao K, Tang H.   +12 more
europepmc   +3 more sources

Identification of stimuli that enhance human herpesvirus 6A (HHV-6A) replication and reconstitution. [PDF]

J Virol
ABSTRACT Despite the availability of bacterial artificial chromosome (BAC) systems for human herpesvirus 6A (HHV-6A), reconstitution of infectious viruses is very challenging and time consuming. In this study, we developed approaches to improve the reconstitution process and enhance virus replication to overcome ...
Reich J, Serdar D, Weißmann A-C, Kaufer BB.   +3 more
europepmc   +3 more sources

CD46 Isoforms Influence the Mode of Entry by Human Herpesvirus 6A/B in T Cells. [PDF]

J Virol, 2022
CD46 is the receptor used by human herpesvirus 6A (HHV-6A) during infection of T cells, but it is also involved in infection of certain T cells by HHV-6B. The gene for CD46 allows expression of several variants of CD46, known as isoforms, but whether the isoforms matter for infection of T cells is unknown.
Rossen LS, Schack VR, Thuesen KKH, Bundgaard B, Höllsberg P.   +4 more
europepmc   +3 more sources

ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. [PDF]

J Virol, 2022
Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction.
Aktar S, Arii J, Nguyen TTH, Huang JR, Nishimura M, Mori Y.   +5 more
europepmc   +3 more sources

Human Herpesvirus 6A (HHV-6A) Encephalitis in an Immunocompetent Patient and Its Association With Glioblastoma: A Case Report. [PDF]

Cureus
Human herpesvirus 6 (HHV-6) is a neurotropic virus capable of establishing latency in the central nervous system. While its reactivation is well-documented in immunocompromised individuals, its role in immunocompetent hosts remains unclear. Additionally, growing but inconclusive evidence suggests a potential association between HHV-6 and glioblastoma ...
Aleixo R, Sá R, Ramos I, Valente C.
europepmc   +3 more sources