Results 31 to 40 of about 130,487 (185)

Human herpesvirus 6A accelerates AIDS progression in macaques [PDF]

Proceedings of the National Academy of Sciences, 2007
Although HIV is the necessary and sufficient causative agent of AIDS, genetic and environmental factors markedly influence the pace of disease progression. Clinical and experimental evidence suggests that human herpesvirus 6A (HHV-6A), a cytopathic T-lymphotropic DNA virus, fosters the progression to AIDS in synergy with HIV-1.
Lusso P, Crowley RW, Malnati MS, DI SERIO , MARIACLELIA, PONZONI , MAURILIO, Biancotto A, Markham PD, Gallo RC   +7 more
openaire   +4 more sources

Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A [PDF]

Journal of Virology, 1999
ABSTRACT Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but ...
G, Dominguez, T R, Dambaugh, F R, Stamey, S, Dewhurst, N, Inoue, P E, Pellett   +5 more
openaire   +2 more sources

Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. [PDF]

Future Virol, 2013
Like other members of the Herpesviridae family, human herpesvirus (HHV)-6A and HHV-6B have developed a wide variety of strategies to modulate or suppress host immune responses and, thereby, facilitate their own spread and persistence in vivo. Long considered two variants of the same virus, HHV-6A and HHV-6B have recently been reclassified as distinct ...
Dagna L, Pritchett JC, Lusso P.
europepmc   +6 more sources

Human Herpesvirus 6A (HHV-6A) Encephalitis in an Immunocompetent Patient and Its Association With Glioblastoma: A Case Report. [PDF]

Cureus
Human herpesvirus 6 (HHV-6) is a neurotropic virus capable of establishing latency in the central nervous system. While its reactivation is well-documented in immunocompromised individuals, its role in immunocompetent hosts remains unclear. Additionally, growing but inconclusive evidence suggests a potential association between HHV-6 and glioblastoma ...
Aleixo R, Sá R, Ramos I, Valente C.
europepmc   +3 more sources

Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration. [PDF]

J Virol, 2017
ABSTRACT Human herpesviruses 6A/B (HHV-6A/B) can integrate their viral genomes in the telomeres of human chromosomes. The viral and cellular factors contributing to HHV-6A/B integration remain largely unknown, mostly due to the lack of efficient and reproducible cell culture models to study HHV-6A/B integration. In this study, we
Gravel A, Dubuc I, Wallaschek N, Gilbert-Girard S, Collin V, Hall-Sedlak R, Jerome KR, Mori Y, Carbonneau J, Boivin G, Kaufer BB, Flamand L.   +11 more
europepmc   +4 more sources

Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites

Frontiers in Cellular and Infection Microbiology, 2021
Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani, Cosima Zimmerman, Princess Rodriguez, Ellie Hasenohr, Giulia Aimola, Diana Lea Gerrard, Alyssa Richman, Andrea Dest, Louis Flamand, Benedikt Kaufer, Seth Frietze, Seth Frietze   +11 more
doaj   +1 more source

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration. [PDF]

PLoS Pathog, 2020
Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. Viral integration occurs at the ends of chromosomes within the host telomeres. The ends of the HHV-6A/B genomes contain telomeric repeats that facilitate the integration process. Here, we report that productive
Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L.   +6 more
europepmc   +5 more sources

A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion [PDF]

, 2017
The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Beatrice Plougastel-Douglas, Daved H. Fremont, David Wang, Elvin J. Lauron, Eugene Park, Guoyan Zhao, Ian B. Harvey, Jennifer Poursine-Laurent, Swapneel J. Patel, Vinay R. Penna, Wandy L. Beatty, Wayne M. Yokoyama   +11 more
core   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. [PDF]

PLoS ONE, 2009
The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53.
Mariane H Schleimann, Janni M L Møller, Emil Kofod-Olsen, Per Höllsberg   +3 more
doaj   +1 more source