Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites
Frontiers in Cellular and Infection Microbiology, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani +11 more
doaj +1 more source
Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America. [PDF]
, 2015 The genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies.
Spyrou, MA +5 more
core +1 more source
Characterization of the human herpesvirus 6A U23 gene
Virology, 2014 Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A ...
Hayashi, Mayuko +6 more
openaire +2 more sources
Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. [PDF]
PLoS ONE, 2009 The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53.
Mariane H Schleimann +3 more
doaj +1 more source
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?
Neural Regeneration Research, 2019 Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease, a common form of dementia that afflicts a large percentage of elderly individuals.
Maria Anele Romeo +2 more
doaj +1 more source
Mapping the telomere integrated genome of human herpesvirus 6A and 6B. [PDF]
Virology, 2013 Human herpesvirus 6B (HHV-6B) is the causative agent of roseola infantum. HHV-6A and 6B can reactivate in immunosuppressed individuals and are linked with severe inflammatory response, organ rejection and central nervous system diseases. About 0.85% of the US and UK population carries an integrated HHV-6 genome in all nucleated cells through germline ...
Arbuckle JH +6 more
europepmc +3 more sources
Human Herpesviruses 6A and 6B in Reproductive Diseases
Frontiers in Immunology, 2021 Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)—collectively, HHV-6A/B—are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable ...
Anthony L. Komaroff +2 more
doaj +1 more source
A human herpesvirus 6A-encoded microRNA: role in viral lytic replication. [PDF]
J Virol, 2015 ABSTRACT Human herpesvirus 6A (HHV-6A), a member of the betaherpesvirus family, is associated with several human diseases. Like all herpesviruses, HHV-6A establishes a lifelong, latent infection in its host. Reactivation of HHV-6A is frequent within the immunosuppressed and immunocompromised populations and results in lytic viral replication ...
Nukui M, Mori Y, Murphy EA.
europepmc +4 more sources
The U94 Gene of Human Herpesvirus 6: A Narrative Review of Its Role and Potential Functions
Cells, 2020 Human herpesvirus 6 (HHV-6) is a β-herpesvirus that is highly prevalent in the human population. HHV-6 comprises two recognized species (HHV-6A and HHV-6B).
Elisabetta Caselli +12 more
doaj +1 more source
Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS
Viruses, 2022 A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous ...
Keng-Shuo Pi +11 more
doaj +1 more source