Results 61 to 70 of about 7,619,474 (155)

Acute Human Herpesvirus-6A infection of human mesothelial cells modulates HLA molecules

, 2015
Human herpesvirus 6A (HHV-6A) causes ubiquitous infections, and has been associated with several diseases in immunosuppressed and immune dysregulated individuals.
RIZZO, Roberta, CASELLI, Elisabetta, DI LUCA, Dario, CUNEO, Antonio, CAVAZZINI, Francesco, GENTILI, Valentina, BORTOLOTTI, Daria, CAMPIONI, Diana   +7 more
core   +1 more source

Chromosomal integration of HHV-6A during non-productive viral infection

Scientific Reports, 2017
Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are two different species of betaherpesviruses that integrate into sub-telomeric ends of human chromosomes, for which different prevalence rates of integration have been reported.
Nitish Gulve, Celina Frank, Maximilian Klepsch, Bhupesh K. Prusty   +3 more
doaj   +1 more source

High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort

Frontiers in Transplantation, 2023
Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase
Arturo Blazquez-Navarro, Arturo Blazquez-Navarro, Toralf Roch, Toralf Roch, Patrizia Wehler, Patrizia Wehler, Sviatlana Kaliszczyk, Sviatlana Kaliszczyk, Chris Bauer, Constantin Thieme, Kamil S. Rosiewicz, Ulrik Stervbo, Ulrik Stervbo, Moritz Anft, Petra Reinke, Christian Hugo, Panagiota Zgoura, Richard Viebahn, Timm Westhoff, Michal Or-Guil, Nina Babel, Nina Babel   +21 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways

Virology Journal, 2011
Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous
Gu Bin, Zhang Guo-Feng, Li Ling-Yun, Zhou Feng, Feng Dong-Ju, Ding Chuan-Lin, Chi Jing, Zhang Chun, Guo Dan-Dan, Wang Jing-Feng, Zhou Hong, Yao Kun, Hu Wei-Xing   +12 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis [PDF]

, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Contrant, M, Johanna Viiliäinen, Vladimir Benes, Päivi M. Ojala, Voinnet Olivier, Gros, Frédéric, Voinnet, Olivier, Viiliainen, J, Mihaela Zavolan, Benes, Vladimir, Haas Juergen G., Suffert, G, Georg Malterer, Guillaume Suffert, Malterer, G, Frédéric Gros, Gros Frédéric, Ojala, Päivi M, Viiliäinen, Johanna, Suffert, Guillaume, Olivier Voinnet, Hausser Jean, Fender, A, Malterer Georg, Benes, V, Zavolan Mihaela, Ojala Päivi M., Haas, JG, Päivi M Ojala, Hausser, J, Viiliäinen Johanna, Zavolan, Mihaela, Hausser, Jean, Voinnet, O, Suffert Guillaume, Maud Contrant, Pfeffer Sébastien, Haas, Jürgen G., Zavolan, M, Jean Hausser, Tomi Ivacevic, Contrant Maud, Malterer, Georg, Benes Vladimir, Sébastien Pfeffer, Fender Aurélie, Haas, Juergen G, Ivacevic, T, Ojala, PM, Juergen G Haas, Ivacevic, Tomi, Aurélie Fender, Fender, Aurélie, Ojala, Päivi M., Pfeffer, Sébastien, Gros, F, Pfeffer, S, Contrant, Maud, Juergen G. Haas, Ivacevic Tomi, Haas, Juergen G.   +60 more
core   +1 more source

Diagnostic value of HHV-6A/B genotyping in immunocompromised adults

Journal of Clinical Microbiology
Human herpesvirus 6 (HHV-6) comprises two genetically and biologically distinct species, HHV-6A and HHV-6B, yet species-level differentiation is rarely performed in clinical practice.
Virginia Rodríguez-Lorente, Paola Charry, Ares Guardia, Francesc Fernández-Avilés, Montserrat Rovira, María Queralt Salas, Carmen Martínez, Laura Rosiñol, Marta Bodro, Ana Belén Pérez, Isabel Machuca, Ana Cervilla, María del Mar Mosquera, Miguel J. Martínez, María Suárez-Lledó, María Ángeles Marcos   +15 more
doaj   +1 more source