Results 61 to 70 of about 125,465 (162)

Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators.

, 2014
Human herpesvirus-6A (HHV-6A) is rarer than HHV-6B in many infant populations. However, they are similarly prevalent as germline, chromosomally integrated genomes (ciHHV-6A/B).
Spyrou, MA, Hubacek, P, Lassner, D, Kuhl, U, Gompels, UA, Tweedy, J   +5 more
core   +1 more source

Human herpesvirus 6A infection and immunopathogenesis in humanized Rag2⁻/⁻ γc⁻/⁻ mice. [PDF]

J Virol, 2013
ABSTRACTAlthough serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral infections to disease. HHV-6A and HHV-6B have recently been classified as two distinct viruses, and in this study we focused specifically on developing
Tanner A, Carlson SA, Nukui M, Murphy EA, Berges BK.   +4 more
europepmc   +4 more sources

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Diagnosis of human herpesvirus 6A association infertility by RT-qPCR and detection sanger sequencing

, 2022
Human samples of Human Herpesvirus 6A were collected during 13 October 2021 to 15 of December 2021. Human Herpesvirus 6A was including (15-49years). The real time polymerase chain reaction (RT-qPCR) method was detected of all samples, the results showed ...
Mohan, Douha A'aad, Alameedy, Fadyia Mahdi Muslim   +1 more
core   +1 more source

Enhanced virus reconstitution of human herpesvirus 6A (HHV-6A)

BMC Methods
Abstract Background Human herpesvirus 6A (HHV-6A) is a member of the betaherpesvirus family and is associated with neurotropic diseases. Despite its clinical significance, HHV-6A research has been hampered by challenges in the generation of recombinant viruses.
Reich, Jana, Serdar, Dilan, Ospina, Jenny M., Cheng, Yingnan, Weißmann, Ann-Christin, Woude, Roosmarijn van der, Beythien, Georg, Whyte, Melissa L., Gravel, Annie, Hennig, Thomas, Flamand, Louis, Hudson, Amy, Kaufer, Benedikt B.   +12 more
openaire   +1 more source

Comparative characteristics of human betaherpesviruses 6A and 6B. A modern view on the problem

Журнал инфектологии, 2021
This review is devoted to the comparative characteristics of human herpesvirus 6A (HHV6A) and human herpesvirus 6B (HHV6B), taking into account their exogenous and endogenous (inherited chromosomally integrated) forms. The analysis of the literature data
M. I. Popkova, O. V. Utkin, D. A. Bryzgalova   +2 more
doaj   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Identification of the Human Herpesvirus 6A gQ1 Domain Essential for Its Functional Conformation [PDF]

Journal of Virology, 2013
ABSTRACT Human herpesvirus 6 is a T lymphotropic herpesvirus, long classified into variants A and B (HHV-6A and HHV-6B) based on differences in sequence and pathogenicity. Recently, however, HHV-6A and HHV-6B were reclassified as different species.
Takahiro, Maeki, Mayuko, Hayashi, Akiko, Kawabata, Huamin, Tang, Koichi, Yamanishi, Yasuko, Mori   +5 more
openaire   +2 more sources

Human Herpesviruses-encoded dUTPases: A Family of Proteins that Modulate Dendritic Cell Function and Innate Immunity

Frontiers in Microbiology, 2014
We have previously shown that Epstein-Barr virus (EBV)-encoded dUTPase can modulate innate immune responses through the activation of TLR2 and NF-kappaB signaling. However, whether this novel immune function of the dUTPase is specific for EBV or a common
Maria Eugenia eAriza, Ronald eGlaser, Marshall Vance Williams   +2 more
doaj   +1 more source

Clinical and etiological aspects of human Betaherpesvirus infection 6: a review

Журнал инфектологии, 2022
The literature review is devoted to the modern concept of human betaherpesvirus 6 (human herpesvirus 6; HHV-6). The analysis of the literature mainly for the last five years was carried out.
N. S. Tian, O. V. Goleva, I. V. Babachenko   +2 more
doaj   +1 more source