Results 81 to 90 of about 130,487 (185)

High incidence and viral load of HHV-6A in a multi-centre kidney transplant cohort

Frontiers in Transplantation, 2023
Human herpesvirus 6 (HHV-6) is a common opportunistic pathogen in kidney transplant recipients. Two distinct species of HHV-6, HHV-6A and HHV-6B, have been identified, of which the latter seems to be dominant. However, it is unclear whether they increase
Arturo Blazquez-Navarro, Arturo Blazquez-Navarro, Toralf Roch, Toralf Roch, Patrizia Wehler, Patrizia Wehler, Sviatlana Kaliszczyk, Sviatlana Kaliszczyk, Chris Bauer, Constantin Thieme, Kamil S. Rosiewicz, Ulrik Stervbo, Ulrik Stervbo, Moritz Anft, Petra Reinke, Christian Hugo, Panagiota Zgoura, Richard Viebahn, Timm Westhoff, Michal Or-Guil, Nina Babel, Nina Babel   +21 more
doaj   +1 more source

Protein chainmail variants in dsDNA viruses. [PDF]

, 2015
First discovered in bacteriophage HK97, biological chainmail is a highly stable system formed by concatenated protein rings. Each subunit of the ring contains the HK97-like fold, which is characterized by its submarine-like shape with a 5-stranded β ...
Chiou, Joshua, Zhou, Z Hong
core   +2 more sources

Complexities in human herpesvirus-6A and -6B binding to host cells

Virology, 2006
Human herpesvirus-6A and -6B uses the cellular receptor CD46 for fusion and infection of the host cell. The viral glycoprotein complex gH-gL from HHV-6A binds to the short consensus repeat 2 and 3 in CD46. Although all the major isoforms of CD46 bind the virus, certain isoforms may have higher affinity than others for the virus.
Pedersen, Simon Metz, Höllsberg, Per
openaire   +3 more sources

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders [PDF]

, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Aavani, Agut, Albright, Andreasen, Arbuckle, Atmaca, Baldacara, Benros, Bornand, Brambilla, Carvalho, Cerminara, Challoner, Chan, Chen, Conejero-Goldberg, Cuomo, da Silveira, Das, Del Guerra, DelBello, Dhepakson, Donati, Dunham, Esposito, Fatemi, Garcia Bueno, Gerber, Gulve, Hagberg, Johnson, Kawai, Khandaker, Laidi, Loginov, Luppi, Maloku, Moberget, Mori, Munger, Murakami, Nicolson, Niebuhr, Ouwendijk, Parboosing, Pfeiffer, Phillips, Prusty, Prusty, Prusty, Readhead, Reeber, Reynaud, Ritchie, Sakamoto, Santoro, Schindelin, Schmitt, Shi, Stich, Su, Takeda, Torrey, Tran, Ueland, Wang, Williams, Yavarian, Yu   +68 more
core   +2 more sources

Circadian control of interferon-sensitive gene expression in murine skin. [PDF]

, 2020
The circadian clock coordinates a variety of immune responses with signals from the external environment to promote survival. We investigated the potential reciprocal relationship between the circadian clock and skin inflammation.
Andersen, Bogi, Dragan, Morgan, Greenberg, Elyse Noelani, Gudjonsson, Johann E, Jin, Suoqin, Marshall, Michaela Ellen, Nie, Qing, Takahashi, Joseph S, Tsoi, Lam C, Venkatesh, Sanan   +9 more
core   +2 more sources

Neuroinflammation as a result of non‐neurotropic herpesvirus infection

Immunology &Cell Biology, Volume 104, Issue 5, Page 443-451, May‐June 2026.
Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Christian Münz
wiley   +1 more source

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways

Virology Journal, 2011
Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous
Gu Bin, Zhang Guo-Feng, Li Ling-Yun, Zhou Feng, Feng Dong-Ju, Ding Chuan-Lin, Chi Jing, Zhang Chun, Guo Dan-Dan, Wang Jing-Feng, Zhou Hong, Yao Kun, Hu Wei-Xing   +12 more
doaj   +1 more source

Multiple sclerosis: an example of pathogenic viral interaction? [PDF]

, 2017
A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS ...
Walter Fierz
core   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Identification of the Human Herpesvirus 6A gQ1 Domain Essential for Its Functional Conformation [PDF]

Journal of Virology, 2013
ABSTRACT Human herpesvirus 6 is a T lymphotropic herpesvirus, long classified into variants A and B (HHV-6A and HHV-6B) based on differences in sequence and pathogenicity. Recently, however, HHV-6A and HHV-6B were reclassified as different species.
Takahiro, Maeki, Mayuko, Hayashi, Akiko, Kawabata, Huamin, Tang, Koichi, Yamanishi, Yasuko, Mori   +5 more
openaire   +2 more sources