DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS
ABSTRACT A variety of malignancies can be found in the sinonasal tract including the nasal cavity, paranasal sinuses, and skull base. Many of these are attributed to viruses, for example, carcinomas with the presence of transcriptionally active high‐risk human papillomavirus, as well as Epstein–Barr virus associated malignant lymphoepithelial carcinoma
Maria K. Jauhiainen +7 more
wiley +1 more source
Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6
Background Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in ...
Alexander L. Greninger +19 more
doaj +1 more source
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna +19 more
core
Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras +6 more
wiley +1 more source
EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang +4 more
wiley +1 more source
A humán immundeficiencia vírus látens humán herpeszvírus 6-ot aktiváló és NK sejteket fertőző képességének vizsgálata = Studies on the ability of human immunodeficiency virus activate latent human herpesvirus-6 and to infect NK cells [PDF]
A macrophagok mind a humán herpeszvírus 6 A (HHV-6A), mind a humán immundeficiencia vírus 1 (HIV-1) fontos célsejtjei, így jelentős szerepet játszanak e két vírus disszeminációjában, patogenezisében.
Andrikó, István +7 more
core
Regulation of the retinoblastoma proteins by the human herpesviruses [PDF]
Viruses are obligate intracellular parasites that alter the environment of infected cells in order to replicate more efficiently. One way viruses achieve this is by modulating cell cycle progression.
Kalejta Robert F, Hume Adam J
core +2 more sources
Herpesvirus genome integration in whole‐genome sequences of dementia and control cohorts
Abstract INTRODUCTION The infectious hypothesis suggests that microbes like herpesviruses may play a role in the pathogenesis of Alzheimer's disease (AD) and other related dementias through methods that may include viral genome integration. The occurrence of herpesvirus genome integration in dementia patients has not been thoroughly characterized ...
Stacey L. Piotrowski +27 more
wiley +1 more source
Abstract The choice of cell source for generating induced pluripotent stem cells (iPSCs) is influenced by several factors, including accessibility, reprogramming efficiency, and the invasiveness of the cell collection procedure. Traditional sources such as skin fibroblasts or peripheral blood mononuclear cells often require invasive sampling, which can
Laurie Martineau +4 more
wiley +1 more source
GP96 interacts with HHV-6 during viral entry and directs it for cellular degradation.
CD46 and CD134 mediate attachment of Human Herpesvirus 6A (HHV-6A) and HHV-6B to host cell, respectively. But many cell types interfere with viral infection through rapid degradation of viral DNA.
Bhupesh K Prusty +4 more
doaj +1 more source

