Results 91 to 100 of about 125,465 (162)

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]

, 2015
Human herpesvirus-6A (HHV-6A) and HHV-6B inte-grate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown.
Trempe, Frédéric, Morissette, Guillaume, Louis Flam, Gravel, Annie, Dubuc, Isabelle, Nina Wallaschek, Benedikt B. Kaufer, Collin, Vanessa, Guillaume Morissette, Gilbert-Girard, Shella, Annie Gravel, Wallaschek, Nina, Isabelle Dubuc, Shella Gilbert-girard, Vanessa Collin, Flamand, Louis, Kaufer, Benedikt B.   +16 more
core   +1 more source

The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro [PDF]

Proceedings of the National Academy of Sciences, 2010
Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily fluorescence in situ hybridization (FISH)—is indirect. We sought, first, to definitively test these two hypotheses.
Arbuckle, J. H., Medveczky, M. M., Luka, J., Hadley, S. H., Luegmayr, A., Ablashi, D., Lund, T. C., Tolar, J., De Meirleir, K., Montoya, J. G., Komaroff, Anthony, Ambros, P. F., Medveczky, P. G.   +12 more
openaire   +4 more sources

TNF Pathway‐Mediated Tolerogenic T‐Cell Trajectory Driven by Allergen Immunotherapy

Allergy, Volume 81, Issue 6, Page 2184-2197, June 2026.
The study shows that AIT re‐establishes local immune equilibrium by restoring Th17/Treg balance, while circulating Th17 cells remain functionally impaired. The transition from pro‐inflammatory Th17 to regulatory T cell states during AIT identifies Tr17 cells as an intermediate cell population.
Helen S. Charles, Amr A. Gabr, Shu‐Hung Wang, Ulrich M. Zissler, Sonja Heine, Alexander Heldner, Sebastian Kotz, Lisa Pechtold, Lynn S. zur Bonsen, Dimitrii Pogorelov, Josephine Kau, Mirjam Plaschke, Miriam Hills, Ferdinand Guerth, Madlen Oelsner, Caspar Ohnmacht, Francesca Alessandrini, Simon Blank, Adam M. Chaker, Carsten B. Schmidt‐Weber, Constanze A. Jakwerth   +20 more
wiley   +1 more source

Molecular Mimicry Between Epstein‐Barr Virus and Human Herpesvirus‐6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background The Epstein‐Barr virus (EBV) and human herpesvirus 6 (HHV‐6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis. These viruses may induce autoimmune reactions by molecular mimicry, leading to damage to self‐epitopes in the central nervous
Abbas F. Almulla, Muslimbek G. Normatov, Thitiporn Supasitthumrong, Michael Maes   +3 more
wiley   +1 more source

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6

BMC Genomics, 2018
Background Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in ...
Alexander L. Greninger, Giselle M. Knudsen, Pavitra Roychoudhury, Derek J. Hanson, Ruth Hall Sedlak, Hong Xie, Jon Guan, Thuy Nguyen, Vikas Peddu, Michael Boeckh, Meei-Li Huang, Linda Cook, Daniel P. Depledge, Danielle M. Zerr, David M. Koelle, Soren Gantt, Tetsushi Yoshikawa, Mary Caserta, Joshua A. Hill, Keith R. Jerome   +19 more
doaj   +1 more source

Drug‐induced hypersensitivity syndrome followed by exacerbation of Crohn's disease

Pediatric Investigation, EarlyView.
Mei Kamidani, Ryo Tanaka, Hiroshi Oue, Risa Fukuda, Rena Hashimoto, Ichiro Takeuchi, Takako Yoshioka, Naoya Tonegawa, Akira Ishiguro, Katsuhiro Arai, Kazue Yoshida   +10 more
wiley   +1 more source

Progress and Prospects of Rare Metal‐Based Electrochemiluminescence Sensors for Detection of Water Environmental Pollutants

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Water pollution is becoming increasingly severe, posing a serious hazard to human health and ecological security. Therefore, it is necessary to develop rapid, sensitive, and universal analytical methods to detect residual pollutants in actual water.
Yi Xing, Ru Wu, Min Zhang, Faliang Cheng, Jun‐Jie Zhu   +4 more
wiley   +1 more source

Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules

, 2007
Like all other members of the herpesvirus family, the closely related human herpesviruses-6 and -7 (HHV-6,7) persist in their host throughout life. In so doing, without exception, every member of the herpesvirus family has evolved mechanisms to avoid ...
Hudson, Amy W., Glosson, Nicole L.
core   +1 more source

Neuroinflammation as a result of non‐neurotropic herpesvirus infection

Immunology &Cell Biology, Volume 104, Issue 5, Page 443-451, May‐June 2026.
Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Christian Münz
wiley   +1 more source

Gene expression studies of lytic infection and chromosomal integration of human herpesvirus 6.

, 2008
Human herpesvirus 6 (HHV-6) was discovered in 1986 in patients with lymphoproliferative diseases and it has a predominant tropism for CD4+ T cells in vitro and in vivo.
Tsao, E.H.F.
core