Results 91 to 100 of about 7,974,842 (159)

Host-directed clearance of nuclear tegument U14 terminates NF-κB signaling and supports HHV-6A replication.

PLoS Pathogens
Innate immune and cellular stress responses triggered by infection must be transient and tightly controlled to restrain pathogens without harming the host. Herpesvirus infection induces NF-κB signaling through multiple viral and host inputs, yet how this
Khoir Amaliin, Mansaku Hirai, Salma Aktar, Tetsuo Koshizuka, Yasuko Mori, Jun Arii   +5 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Diagnostic value of HHV-6A/B genotyping in immunocompromised adults

Journal of Clinical Microbiology
Human herpesvirus 6 (HHV-6) comprises two genetically and biologically distinct species, HHV-6A and HHV-6B, yet species-level differentiation is rarely performed in clinical practice.
Virginia Rodríguez-Lorente, Paola Charry, Ares Guardia, Francesc Fernández-Avilés, Montserrat Rovira, María Queralt Salas, Carmen Martínez, Laura Rosiñol, Marta Bodro, Ana Belén Pérez, Isabel Machuca, Ana Cervilla, María del Mar Mosquera, Miguel J. Martínez, María Suárez-Lledó, María Ángeles Marcos   +15 more
doaj   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, Volume 42, Issue 5, September/October 2026.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Multiple human herpesvirus-8 infection [PDF]

, 2003
In Malawian patients with Kaposi sarcoma (KS) and their relatives, we investigated nucleotide-sequence variation in human herpesvirus-8 (HHV-8) subgenomic DNA, amplified from oral and blood samples by use of polymerase chain reaction.
Teo, CG, Kondowe, W, Beyari, MM, Scully, CM, Cook, RD, Molyneux, EM, Porter, SR, Hodgson, TA   +7 more
core  

The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro [PDF]

Proceedings of the National Academy of Sciences, 2010
Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily fluorescence in situ hybridization (FISH)—is indirect. We sought, first, to definitively test these two hypotheses.
Arbuckle, J. H., Medveczky, M. M., Luka, J., Hadley, S. H., Luegmayr, A., Ablashi, D., Lund, T. C., Tolar, J., De Meirleir, K., Montoya, J. G., Komaroff, Anthony, Ambros, P. F., Medveczky, P. G.   +12 more
openaire   +4 more sources

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, Volume 179, Issue 1, Page 54-71, September 2026.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]

, 2015
Human herpesvirus-6A (HHV-6A) and HHV-6B inte-grate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown.
Trempe, Frédéric, Morissette, Guillaume, Louis Flam, Gravel, Annie, Dubuc, Isabelle, Nina Wallaschek, Benedikt B. Kaufer, Collin, Vanessa, Guillaume Morissette, Gilbert-Girard, Shella, Annie Gravel, Wallaschek, Nina, Isabelle Dubuc, Shella Gilbert-girard, Vanessa Collin, Flamand, Louis, Kaufer, Benedikt B.   +16 more
core   +1 more source