Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis. [PDF]
Brain, 2023 Abstract Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an
Grut V +19 more
europepmc +5 more sources
Prevalence of Chromosomally Integrated Human Herpesvirus 6 in Patients with Human Herpesvirus 6–Central Nervous System Dysfunction [PDF]
, 2014 We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6).
Beranzoli, Laura +13 more
core +1 more source
Characterization of the human herpesvirus 6A U23 gene
Virology, 2014 Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A ...
Hayashi, Mayuko +6 more
openaire +2 more sources
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?
Neural Regeneration Research, 2019 Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease, a common form of dementia that afflicts a large percentage of elderly individuals.
Maria Anele Romeo +2 more
doaj +1 more source
Human Herpesviruses 6A and 6B in Reproductive Diseases
Frontiers in Immunology, 2021 Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)—collectively, HHV-6A/B—are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable ...
Anthony L. Komaroff +2 more
doaj +1 more source
A human herpesvirus 6A-encoded microRNA: role in viral lytic replication. [PDF]
J Virol, 2015 ABSTRACT Human herpesvirus 6A (HHV-6A), a member of the betaherpesvirus family, is associated with several human diseases. Like all herpesviruses, HHV-6A establishes a lifelong, latent infection in its host. Reactivation of HHV-6A is frequent within the immunosuppressed and immunocompromised populations and results in lytic viral replication ...
Nukui M, Mori Y, Murphy EA.
europepmc +4 more sources
Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]
, 2015 Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown. HHV-6A/B encode a protein that has been proposed to be involved in integration termed
Collin, Vanessa +8 more
core +1 more source
Recent developments in animal models for human herpesvirus 6A and 6B. [PDF]
Curr Opin Virol, 2014 Progress in the identification of suitable animal models for human herpesvirus (HHV)-6A and HHV-6B infections has been slow. Recently, new models have been established, mainly for HHV-6A, which reproduce some pathological features seen in humans. Neuroinflammatory signs were observed in infected marmosets and CD46-transgenic mice; although viral ...
Horvat B, Berges BK, Lusso P.
europepmc +6 more sources
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]
, 2017 KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara +7 more
core +2 more sources