Human Herpesvirus 6A U14 Is Important for Virus Maturation. [PDF]
J Virol, 2016 ABSTRACT Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14.
Mori J +4 more
europepmc +4 more sources
Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. [PDF]
Future Virol, 2013 Like other members of the Herpesviridae family, human herpesvirus (HHV)-6A and HHV-6B have developed a wide variety of strategies to modulate or suppress host immune responses and, thereby, facilitate their own spread and persistence in vivo. Long considered two variants of the same virus, HHV-6A and HHV-6B have recently been reclassified as distinct ...
Dagna L, Pritchett JC, Lusso P.
europepmc +6 more sources
Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A [PDF]
Journal of Virology, 1999 ABSTRACT Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but ...
G, Dominguez +5 more
openaire +2 more sources
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +1 more source
HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q [PDF]
, 2016 Primary effusion lymphomas (PEL) are associated with human herpesvirus-8 (HHV-8) and usually occur in immunocompromised individuals. However, there are numerous reports of HHV-8-unrelated PEL-like lymphomas with unknown aetiology. Here we characterize an
Nicola J. Royle (7581539) +14 more
core +4 more sources
Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. [PDF]
J Virol, 2017 Immediate early proteins of human herpesvirus 6A (HHV-6A) are expressed at the outset of lytic infection and thereby regulate viral gene expression. Immediate early protein 2 (IE2) of HHV-6A is a transactivator that drives a variety of promoters.
Nishimura M +4 more
europepmc +2 more sources
Detection some clinical parameters in patients infected with human herpesvirus 6A that cause infertility [PDF]
, 2022 Human samples of Human Herpesvirus 6A were collected during October, 13teen, 2021 to 15 of December 2021. Human Herpesvirus 6A was including (15 - 59 years).
Mohan, Douha A'aad +3 more
core +1 more source
Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration. [PDF]
PLoS Pathog, 2020 Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. Viral integration occurs at the ends of chromosomes within the host telomeres. The ends of the HHV-6A/B genomes contain telomeric repeats that facilitate the integration process. Here, we report that productive
Gilbert-Girard S +6 more
europepmc +5 more sources
Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis. [PDF]
Brain, 2023 Abstract Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an
Grut V +19 more
europepmc +5 more sources
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source