Results 41 to 50 of about 125,465 (162)

Immunomodulation and immunosuppression by human herpesvirus 6A and 6B. [PDF]

Future Virol, 2013
Like other members of the Herpesviridae family, human herpesvirus (HHV)-6A and HHV-6B have developed a wide variety of strategies to modulate or suppress host immune responses and, thereby, facilitate their own spread and persistence in vivo. Long considered two variants of the same virus, HHV-6A and HHV-6B have recently been reclassified as distinct ...
Dagna L, Pritchett JC, Lusso P.
europepmc   +6 more sources

Human Herpesvirus 6A U14 Is Important for Virus Maturation. [PDF]

J Virol, 2016
ABSTRACT Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14.
Mori J, Tang H, Kawabata A, Koike M, Mori Y.   +4 more
europepmc   +4 more sources

Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. [PDF]

J Virol, 2017
Immediate early proteins of human herpesvirus 6A (HHV-6A) are expressed at the outset of lytic infection and thereby regulate viral gene expression. Immediate early protein 2 (IE2) of HHV-6A is a transactivator that drives a variety of promoters.
Nishimura M, Wang J, Wakata A, Sakamoto K, Mori Y.   +4 more
europepmc   +2 more sources

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration. [PDF]

PLoS Pathog, 2020
Human herpesviruses 6A and 6B (HHV-6A/B) are unique among human herpesviruses in their ability to integrate their genome into host chromosomes. Viral integration occurs at the ends of chromosomes within the host telomeres. The ends of the HHV-6A/B genomes contain telomeric repeats that facilitate the integration process. Here, we report that productive
Gilbert-Girard S, Gravel A, Collin V, Wight DJ, Kaufer BB, Lazzerini-Denchi E, Flamand L.   +6 more
europepmc   +5 more sources

Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A [PDF]

Journal of Virology, 1999
ABSTRACT Human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) are closely related viruses that can be readily distinguished by comparison of restriction endonuclease profiles and nucleotide sequences. The viruses are similar with respect to genomic and genetic organization, and their genomes cross-hybridize extensively, but ...
G, Dominguez, T R, Dambaugh, F R, Stamey, S, Dewhurst, N, Inoue, P E, Pellett   +5 more
openaire   +2 more sources

The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity. [PDF]

J Virol, 2018
Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a glycoprotein consisting of 830 amino acids and is essential for the growth of the virus. Previously, we reported that a neutralizing monoclonal antibody (MAb) called 87-y-13 specifically reacts with ...
Wakata A, Kanemoto S, Tang H, Kawabata A, Nishimura M, Jasirwan C, Mahmoud NF, Mori Y.   +7 more
europepmc   +2 more sources

Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis. [PDF]

Brain, 2023
Abstract Recent research indicates that multiple sclerosis is preceded by a prodromal phase with elevated levels of serum neurofilament light chain (sNfL), a marker of axonal injury. The effect of environmental risk factors on the extent of axonal injury during this prodrome is unknown. Human herpesvirus 6A (HHV-6A) is associated with an
Grut V, Biström M, Salzer J, Stridh P, Jons D, Gustafsson R, Fogdell-Hahn A, Huang J, Butt J, Lindam A, Alonso-Magdalena L, Bergström T, Kockum I, Waterboer T, Olsson T, Zetterberg H, Blennow K, Andersen O, Nilsson S, Sundström P.   +19 more
europepmc   +5 more sources

Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America. [PDF]

, 2015
The genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies.
Spyrou, MA, Breuer, J, Gompels, UA, Tweedy, J, Depledge, D, Donaldson, CD   +5 more
core   +1 more source

Detection some clinical parameters in patients infected with human herpesvirus 6A that cause infertility

, 2022
Human samples of Human Herpesvirus 6A were collected during October, 13teen, 2021 to 15 of December 2021. Human Herpesvirus 6A was including (15 - 59 years).
Mohan, Douha A'aad, Alameedy, Fadyia Mahdi Muslim   +1 more
core   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source