Results 21 to 30 of about 130,487 (185)
The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome [PDF]
Viruses, 2018 Human herpesvirus 6A (HHV-6A) replicates in peripheral blood mononuclear cells (PBMCs) and various T-cell lines in vitro. Intriguingly, the virus can also establish latency in these cells, but it remains unknown what influences the decision between lytic
Anirban Sanyal +5 more
doaj +2 more sources
Excision of Integrated Human Herpesvirus 6A Genomes Using CRISPR/Cas9 Technology. [PDF]
Microbiol Spectr, 2023 Human herpesvirus 6 (HHV-6) infects almost all humans and integrates into the telomeres of latently infected cells to persist in the host for life. In addition, HHV-6 can also integrate into the telomeres of germ cells, which results in about 80 million individuals worldwide who carry the virus in every cell of their body and can pass it on to their ...
Aimola G +3 more
europepmc +3 more sources
ATF1 Restricts Human Herpesvirus 6A Replication via Beta Interferon Induction. [PDF]
J Virol, 2022 Human herpesvirus 6A (HHV-6A) is a ubiquitous herpesvirus implicated in Alzheimer’s disease, although its role in its pathogenesis has not been confirmed. Here, we showed that the transcription factor ATF1 restricts HHV-6A replication, mediated by IFN-β induction.
Aktar S +5 more
europepmc +3 more sources
Prevalence of human herpesvirus 6A and 6B during pregnancy [PDF]
Acta Microbiologica et Immunologica Hungarica, 2017 The aim of the present study was to assess the frequency of human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) infection during pregnancy. 100–100 blood samples were collected from pregnant and non-pregnant women, then nucleic acid was isolated from both plasma and leukocytes fraction.
Csoma, Eszter +3 more
core +4 more sources
Purification of infectious human herpesvirus 6A virions and association of host cell proteins [PDF]
Virology Journal, 2007 Background Viruses that are incorporating host cell proteins might trigger autoimmune diseases. It is therefore of interest to identify possible host proteins associated with viruses, especially for enveloped viruses that have been suggested to play a ...
Garoff Henrik +4 more
doaj +3 more sources
gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections. [PDF]
J Virol, 2020 Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Ma J +11 more
europepmc +4 more sources
Human Herpesvirus 6A U4 Inhibits Proteasomal Degradation of the Amyloid Precursor Protein. [PDF]
J Virol, 2022 The association of HHV-6A infection with Alzheimer’s disease has attracted increasing attention, although its role and molecular mechanism remain to be established. Our results here indicate that HHV-6A U4 inhibits amyloid precursor protein (APP) degradation.
Tang T +12 more
europepmc +3 more sources
Human Herpesvirus 6A U14 Is Important for Virus Maturation. [PDF]
J Virol, 2016 ABSTRACT Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14.
Mori J +4 more
europepmc +4 more sources
Human herpesvirus 6A and 6B and NK cells [PDF]
Acta Microbiologica et Immunologica Hungarica, 2018 Human herpesvirus 6 (HHV-6) comprises two viral species, HHV-6A and HHV-6B, closely related but differing for pathogenic and biological characteristics. Both viral species are predominantly lymphotropic, infecting T lymphocytes and other lymphoid cells, including natural killer (NK) cells.
Roberta Rizzo, Dario Di Luca
openaire +4 more sources
The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +1 more source