The HHV-6A Proteins U20 and U21 Target NKG2D Ligands to Escape Immune Recognition
Frontiers in Immunology, 2021 The coevolution of the human immune system and herpesviruses led to the emergence and diversification of both cellular danger molecules recognized by immune cells on the one hand and viral countermeasures that prevent the expression of these proteins on ...
Abigael Eva Chaouat +5 more
doaj +1 more source
Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2. [PDF]
J Virol, 2017 Immediate early proteins of human herpesvirus 6A (HHV-6A) are expressed at the outset of lytic infection and thereby regulate viral gene expression. Immediate early protein 2 (IE2) of HHV-6A is a transactivator that drives a variety of promoters.
Nishimura M +4 more
europepmc +2 more sources
Higher-Order Chromatin Structures of Chromosomally Integrated HHV-6A Predict Integration Sites
Frontiers in Cellular and Infection Microbiology, 2021 Human herpesvirus -6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes. Viral integration can occur in several cell types, including germinal cells, resulting in individuals that harbor the viral genome in every cell ...
Michael Mariani +11 more
doaj +1 more source
Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America. [PDF]
, 2015 The genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies.
Spyrou, MA +5 more
core +1 more source
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. [PDF]
PLoS ONE, 2009 The SalI-L fragment from human herpesvirus 6A (HHV-6A) encodes a protein DR7 that has been reported to produce fibrosarcomas when injected into nude mice, to transform NIH3T3 cells, and to interact with and inhibit the function of p53.
Mariane H Schleimann +3 more
doaj +1 more source
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?
Neural Regeneration Research, 2019 Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease, a common form of dementia that afflicts a large percentage of elderly individuals.
Maria Anele Romeo +2 more
doaj +1 more source
Human Herpesviruses 6A and 6B in Reproductive Diseases
Frontiers in Immunology, 2021 Human herpesviruses 6A (HHV-6A) and human herpesvirus 6B (HHV-6B)—collectively, HHV-6A/B—are recently-discovered but ancient human viruses. The vast majority of people acquire one or both viruses, typically very early in life, producing an ineradicable ...
Anthony L. Komaroff +2 more
doaj +1 more source
The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity. [PDF]
J Virol, 2018 Human herpesvirus 6A (HHV-6A) glycoprotein B (gB) is a glycoprotein consisting of 830 amino acids and is essential for the growth of the virus. Previously, we reported that a neutralizing monoclonal antibody (MAb) called 87-y-13 specifically reacts with ...
Wakata A +7 more
europepmc +2 more sources
The U94 Gene of Human Herpesvirus 6: A Narrative Review of Its Role and Potential Functions
Cells, 2020 Human herpesvirus 6 (HHV-6) is a β-herpesvirus that is highly prevalent in the human population. HHV-6 comprises two recognized species (HHV-6A and HHV-6B).
Elisabetta Caselli +12 more
doaj +1 more source