Results 31 to 40 of about 3,187 (152)

The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated. [PDF]

Genes (Basel), 2023
Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DRR) region. It has been shown experimentally that perfect telomeric repeats (pTMR) in the DRR region are required for the ...
Kusakin AV, Goleva OV, Danilov LG, Krylov AV, Tsay VV, Kalinin RS, Tian NS, Eismont YA, Mukomolova AL, Chukhlovin AB, Komissarov AS, Glotov OS.   +11 more
europepmc   +3 more sources

Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations. [PDF]

Virus Evol, 2020
AbstractHuman betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6A/HHV-6B, iciHHV-6A/iciHHV-6B).
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +5 more sources

Classification of HHV-6A and HHV-6B as distinct viruses. [PDF]

Arch Virol, 2014
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-
Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T.   +20 more
europepmc   +6 more sources

Retraction to: A complex evolutionary relationship between HHV-6A and HHV-6B. [PDF]

Virus Evol, 2019
[This retracts the article DOI: 10.1093/ve/vez043.].
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +4 more sources

Investigation of Inherited Chromosomally Integrated Human Herpesvirus-6A+ and -6B+ in a Patient with Ulipristal Acetate-Induced Fulminant Hepatic Failure

Viruses, 2021
Inherited chromosomally integrated (ici) human herpes virus 6 (HHV-6) is estimated to occur in 0.6–2.7% of people worldwide. HHV-6 comprises two distinct species: HHV-6A and HHV-6B. Both HHV-6A and HHV-6B integration have been reported. Several drugs are
Laure Izquierdo, Clémence M. Canivet, Eleonora De Martin, Teresa M. Antonini, Anne-Marie Roque-Afonso, Audrey Coilly, Claire Deback   +6 more
doaj   +1 more source

A complex evolutionary relationship between HHV-6A and HHV-6B.

Virus Evol, 2019
Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6, iciHHV6). We reconstructed the population structure of HHV-6 and we show that HHV-6A genomes
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +4 more sources

Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis

Frontiers in Immunology, 2022
The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to detect ...
Wangko Lundström, Rasmus Gustafsson
doaj   +1 more source

Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. [PDF]

PLoS Pathogens, 2013
Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory demyelinating disease affecting the ...
Emily Leibovitch, Jillian E Wohler, Sheila M Cummings Macri, Kelsey Motanic, Erin Harberts, María I Gaitán, Pietro Maggi, Mary Ellis, Susan Westmoreland, Afonso Silva, Daniel S Reich, Steven Jacobson   +11 more
doaj   +1 more source

Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis. [PDF]

PLoS ONE, 2014
To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up.We collected 2163 serum samples from ...
Isabel Ortega-Madueño, Marta Garcia-Montojo, Maria Inmaculada Dominguez-Mozo, Angel Garcia-Martinez, Ana Maria Arias-Leal, Ignacio Casanova, Rafael Arroyo, Roberto Alvarez-Lafuente   +7 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source