Results 41 to 50 of about 52,056 (173)

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A

Frontiers in Microbiology, 2019
Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Anthony J. Saviola, Cosima Zimmermann, Michael P. Mariani, Sylvia A. Signorelli, Diana L. Gerrard, Joseph R. Boyd, Darren J. Wight, Guillaume Morissette, Annie Gravel, Isabelle Dubuc, Louis Flamand, Benedikt B. Kaufer, Seth Frietze   +12 more
doaj   +1 more source

Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. [PDF]

PLoS ONE, 2013
Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the ...
Rasmus K L Gustafsson, Elin E Engdahl, Oscar Hammarfjord, Sanjaya B Adikari, Magda Lourda, Jonas Klingström, Mattias Svensson, Anna Fogdell-Hahn   +7 more
doaj   +1 more source

Features of Human Herpesvirus-6A and -6B Entry

Advances in Virology, 2012
Human herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species ...
Takahiro Maeki, Yasuko Mori
doaj   +1 more source

Impact of Host Telomere Length on HHV-6 Integration

Viruses, 2022
Human herpesvirus 6A and 6B are two closely related viruses that infect almost all humans. In contrast to most herpesviruses, HHV-6A/B can integrate their genomes into the telomeres during the infection process.
Darren J. Wight, Giulia Aimola, Georg Beythien, Louis Flamand, Benedikt B. Kaufer   +4 more
doaj   +1 more source

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

Frontiers in Microbiology, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty, Bhupesh K. Prusty, Nitish Gulve, Sheila Govind, Gerhard R. F. Krueger, Julia Feichtinger, Julia Feichtinger, Lee Larcombe, Richard Aspinall, Dharam V. Ablashi, Carla T. Toro, Carla T. Toro   +11 more
doaj   +1 more source

Human herpesvirus 6A promotes glycolysis in infected T cells by activation of mTOR signaling.

PLoS Pathogens, 2020
Human herpesvirus 6 (HHV-6) is an important immunosuppressive and immunomodulatory virus worldwide. However, whether and how HHV-6 infection influences the metabolic machinery of the host cell to provide the energy and biosynthetic resources for virus ...
Zhisheng Wu, Junli Jia, Xianyi Xu, Mengyuan Xu, Guangyong Peng, Jingjing Ma, Xuefeng Jiang, Jialin Yao, Kun Yao, Lingyun Li, Huamin Tang   +10 more
doaj   +1 more source

Complete Genome Sequence of Germline Chromosomally Integrated Human Herpesvirus 6A and Analyses Integration Sites Define a New Human Endogenous Virus with Potential to Reactivate as an Emerging Infection

Viruses, 2016
Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”.
Joshua Tweedy, Maria Alexandra Spyrou, Max Pearson, Dirk Lassner, Uwe Kuhl, Ursula A. Gompels   +5 more
doaj   +1 more source

A complex evolutionary relationship between HHV-6A and HHV-6B.

Virus Evol, 2019
Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated HHV-6, iciHHV6). We reconstructed the population structure of HHV-6 and we show that HHV-6A genomes
Forni D, Cagliani R, Clerici M, Pozzoli U, Sironi M.   +4 more
europepmc   +3 more sources

Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators.

, 2014
Human herpesvirus-6A (HHV-6A) is rarer than HHV-6B in many infant populations. However, they are similarly prevalent as germline, chromosomally integrated genomes (ciHHV-6A/B).
Spyrou, MA, Hubacek, P, Lassner, D, Kuhl, U, Gompels, UA, Tweedy, J   +5 more
core   +1 more source

Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways

Virology Journal, 2011
Background Human herpesvirus 6 (HHV-6) is a T-lymphtropic and neurotropic virus that can infect various types of cells. Sequential studies reported that apoptosis of glia and neurons induced by HHV-6 might act a potential trigger for some central nervous
Gu Bin, Zhang Guo-Feng, Li Ling-Yun, Zhou Feng, Feng Dong-Ju, Ding Chuan-Lin, Chi Jing, Zhang Chun, Guo Dan-Dan, Wang Jing-Feng, Zhou Hong, Yao Kun, Hu Wei-Xing   +12 more
doaj   +1 more source