Results 21 to 30 of about 3,187 (152)

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B [PDF]

Nature Communications
Human herpesviruses exhibit diverse pathogenic outcomes and the molecular reasons are not fully understood. Human herpesvirus 6B (HHV-6B) causes exanthema subitum and encephalitis, whereas the closely related HHV-6A is typically asymptomatic.
Jun Arii, Salma Aktar, Jing Rin Huang, Mansaku Hirai, Yoshiki Kawamura, Hiroki Miura, Bochao Wang, Satoshi Nagamata, Mitsuhiro Nishimura, Tetsushi Yoshikawa, Reuben S. Harris, Yasuko Mori   +11 more
doaj   +2 more sources

gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections [PDF]

Journal of Virology, 2020
Although new clinical importance has been revealed for human herpesviruses 6A (HHV-6A) and 6B, much is still unknown about the life cycles of these viruses in target cells. We identified a novel cellular factor, gp96, that is critical for both HHV-6A and -6B entry into host cells.
Zhisheng Wu, Huamin Tang
exaly   +5 more sources

DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]

Frontiers in Microbiology, 2020
ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti, Valentina Gentili, Elisabetta Caselli, Mariangela Sicolo, Irene Soffritti, Maria D’Accolti, Isabel Barao, Isabel Barao, Antonella Rotola, Dario Di Luca, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +2 more sources

The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility [PDF]

Frontiers in Pharmacology, 2020
The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom ...
Anna Pegoraro, Daria Bortolotti, Roberto Marci, Roberto Marci, Elisabetta Caselli, Simonetta Falzoni, Elena De Marchi, Francesco Di Virgilio, Roberta Rizzo, Elena Adinolfi   +9 more
doaj   +2 more sources

HHV-6A Infection of Endometrial Epithelial Cells Induces Increased Endometrial NK Cell-Mediated Cytotoxicity [PDF]

Frontiers in Microbiology, 2017
Background: We have recently reported the presence of Human herpesvirus-6A (HHV-6A) DNA in the 43% of endometrial epithelial cells from primary idiopathic infertile women, with no positivity in fertile women.
Elisabetta Caselli, Daria Bortolotti, Roberto Marci, Antonella Rotola, Valentina Gentili, Irene Soffritti, Maria D’Accolti, Giuseppe Lo Monte, Mariangela Sicolo, Isabel Barao, Dario Di Luca, Roberta Rizzo   +11 more
doaj   +2 more sources

SARS-CoV-2 Infection Associated with HHV-6A Reactivation and an Inhibitory KIR2DL2/HLA-C1 Immunogenetic Profile [PDF]

Microorganisms
Natural killer (NK) cells are central to antiviral immunity through a balance of activating and inhibitory receptors, including killer immunoglobulin-like receptors (KIRs).
Sabrina Rizzo, Matteo Ferraresi, Giovanni Strazzabosco, Marcello Baroni, Juana Maria Sanz, Angelina Passaro, Daria Bortolotti, Roberta Rizzo, Giovanna Schiuma   +8 more
doaj   +2 more sources

Coinfection of human herpesviruses 6A (HHV-6A) and HHV-6B as demonstrated by novel digital droplet PCR assay. [PDF]

PLoS ONE, 2014
The human herpesviruses HHV-6A and HHV-6B have been associated with various neurologic disorders partly due to the detection of elevated viral DNA levels in patients compared to controls.
Emily C Leibovitch, Giovanna S Brunetto, Breanna Caruso, Kaylan Fenton, Joan Ohayon, Daniel S Reich, Steven Jacobson   +6 more
doaj   +2 more sources

Molecular Mimicry Between Epstein-Barr Virus and Human Herpesvirus-6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study. [PDF]

Immun Inflamm Dis
ABSTRACT Background The Epstein‐Barr virus (EBV) and human herpesvirus 6 (HHV‐6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis. These viruses may induce autoimmune reactions by molecular mimicry, leading to damage to self‐epitopes in the central nervous
Almulla AF, Normatov MG, Supasitthumrong T, Maes M.   +3 more
europepmc   +2 more sources

Herpesvirus genome integration in whole-genome sequences of dementia and control cohorts. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The infectious hypothesis suggests that microbes like herpesviruses may play a role in the pathogenesis of Alzheimer's disease (AD) and other related dementias through methods that may include viral genome integration. The occurrence of herpesvirus genome integration in dementia patients has not been thoroughly characterized ...
Piotrowski SL, Allnutt MA, Johnson K, Tanaka T, Ferrucci L, Morris H, Hardy J, PROSPECT Consortium, Ryten M, United Kingdom Brain Expression Consortium (UKBEC), Logroscino G, Troncoso J, Beach TG, Serrano GE, Cruchaga C, Dickson DW, Ross OA, Chiò A, International LBD Genomics Consortium, International ALS Genomics Consortium, Houlden H, American Genome Center, Dalgard CL, Ding J, Gibbs JR, Traynor BJ, Scholz SW, Jacobson S.   +27 more
europepmc   +2 more sources

Clinical and epidemiological features of infections caused by HHV-6A and HHV-6B [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Objective. To determine the detection rates of HHV-6A and HHV-6B compared to other herpes viruses in children of different age groups. Materials and Methods.
Lysenkova M.Yu., Karazhas N.V., Rybalkina T.N., Veselovsky P.A., Burmistrov E.M., Boshyan R.E., Melekhina E.V., Svitich O.A., Muzyka A.D., Petukhova E.V., Gorelov A.V.   +10 more
doaj   +3 more sources