Results 21 to 30 of about 55,098 (145)

The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated. [PDF]

Genes (Basel), 2023
Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DRR) region.
Kusakin AV, Goleva OV, Danilov LG, Krylov AV, Tsay VV, Kalinin RS, Tian NS, Eismont YA, Mukomolova AL, Chukhlovin AB, Komissarov AS, Glotov OS.   +11 more
europepmc   +2 more sources

Investigation of Inherited Chromosomally Integrated Human Herpesvirus-6A+ and -6B+ in a Patient with Ulipristal Acetate-Induced Fulminant Hepatic Failure

Viruses, 2021
Inherited chromosomally integrated (ici) human herpes virus 6 (HHV-6) is estimated to occur in 0.6–2.7% of people worldwide. HHV-6 comprises two distinct species: HHV-6A and HHV-6B. Both HHV-6A and HHV-6B integration have been reported. Several drugs are
Laure Izquierdo, Clémence M. Canivet, Eleonora De Martin, Teresa M. Antonini, Anne-Marie Roque-Afonso, Audrey Coilly, Claire Deback   +6 more
doaj   +1 more source

Classification of HHV-6A and HHV-6B as distinct viruses. [PDF]

Arch Virol, 2014
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses.
Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T.   +20 more
europepmc   +2 more sources

Multiple Sclerosis and Viruses: « Liaisons Dangereuses ». [PDF]

Rev Med Virol
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Plavina S, Malakovska D, Kalnina J, Trapina I, Leonova E, Habib M, Schifmann S, Paramonovs J, Sjakste N, Vassetzky Y, Drouet E, Paramonova N.   +11 more
europepmc   +2 more sources

Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis

Frontiers in Immunology, 2022
The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to detect ...
Wangko Lundström, Rasmus Gustafsson
doaj   +1 more source

Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. [PDF]

PLoS Pathogens, 2013
Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory demyelinating disease affecting the ...
Emily Leibovitch, Jillian E Wohler, Sheila M Cummings Macri, Kelsey Motanic, Erin Harberts, María I Gaitán, Pietro Maggi, Mary Ellis, Susan Westmoreland, Afonso Silva, Daniel S Reich, Steven Jacobson   +11 more
doaj   +1 more source

Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis. [PDF]

PLoS ONE, 2014
To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up.We collected 2163 serum samples from ...
Isabel Ortega-Madueño, Marta Garcia-Montojo, Maria Inmaculada Dominguez-Mozo, Angel Garcia-Martinez, Ana Maria Arias-Leal, Ignacio Casanova, Rafael Arroyo, Roberto Alvarez-Lafuente   +7 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Complete Genome Sequence of the Human Herpesvirus 6A Strain AJ from Africa Resembles Strain GS from North America. [PDF]

, 2015
The genome sequence of human herpesvirus 6A (HHV-6A) strain AJ was determined in a comparison of target enrichment and long-range PCR using next-generation sequencing methodologies.
Spyrou, MA, Breuer, J, Gompels, UA, Tweedy, J, Depledge, D, Donaldson, CD   +5 more
core   +1 more source

Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication

Pathogens, 2021
Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections.
Rasmus Gustafsson
doaj   +1 more source