Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication
Pathogens, 2021 Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections.
Rasmus Gustafsson
doaj +1 more source
Are HHV-6A and HHV-7 Really More Abundant in Alzheimer's Disease? [PDF]
Neuron, 2019 Hyun-hwan Jeong, Zhandong Liu
semanticscholar +3 more sources
Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease
The Scientific World Journal, 2013 Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease ...
Francesco Broccolo +2 more
doaj +1 more source
Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte. [PDF]
Oncotarget, 2016 Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection.
Shao Q +9 more
europepmc +4 more sources
Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]
, 2015 Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown. HHV-6A/B encode a protein that has been proposed to be involved in integration termed
Collin, Vanessa +8 more
core +1 more source
Multiple sclerosis: an example of pathogenic viral interaction? [PDF]
, 2017 A hypothesis is formulated on viral interaction between HHV-6A and EBV as a pathogenic mechanism in Multiple Sclerosis (MS). Evidence of molecular and genetic mechanisms suggests a link between HHV-6A infection and EBV activation in the brain of MS ...
Walter Fierz
core +1 more source
Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. [PDF]
PLoS ONE, 2013 Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the ...
Rasmus K L Gustafsson +7 more
doaj +1 more source
A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion [PDF]
, 2017 The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Beatrice Plougastel-Douglas +11 more
core +2 more sources
Prevalence of Chromosomally Integrated Human Herpesvirus 6 in Patients with Human Herpesvirus 6–Central Nervous System Dysfunction [PDF]
, 2014 We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6).
Beranzoli, Laura +13 more
core +1 more source
Modulatory effects on dendritic cells by human herpesvirus 6 [PDF]
, 2015 Human herpesvirus 6A and 6B are β-herpesviruses approaching 100% seroprevalance worldwide. These viruses are involved in several clinical syndromes and have important immunomodulatory effects.
Anna Fogdell-Hahn +2 more
core +2 more sources