Evolutionary analysis of exogenous and integrated HHV-6A/HHV-6B populations. [PDF]
Virus Evol, 2020 Human betaherpesviruses 6A and 6B (HHV-6A and HHV-6B) are highly prevalent in human populations. The genomes of these viruses can be stably integrated at the telomeres of human chromosomes and be vertically transmitted (inherited chromosomally integrated
Forni D +4 more
europepmc +8 more sources
The HHV-6B U20 glycoprotein binds ULBP1, masking it from recognition by NKG2D and interfering with natural killer cell activation [PDF]
Frontiers in ImmunologyIntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cells,
Grant C. Weaver +9 more
doaj +5 more sources
A Sensitive Quantification of HHV-6B by Real-time PCR [PDF]
Biological Procedures Online, 2002 Human herpesvirus (HHV)-6B is a pathogen causing latent infection in virtually all humans. Nevertheless, the interaction of HHV-6B with its host cells is poorly understood. Although HHV-6B is approximately 90% homologous to HHV-6A, it expresses certain B-
Øster Bodil, Höllsberg Per
doaj +4 more sources
Classification of HHV-6A and HHV-6B as distinct viruses. [PDF]
Arch Virol, 2014 Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-
Ablashi D +20 more
europepmc +8 more sources
HHV-6B ribonucleotide reductase sequesters NF-κB subunit p65 to inhibit innate immune responses. [PDF]
iScienceSummary Human herpesvirus 6B (HHV-6B) belongs to the genus Roseolovirus of the betaherpesvirus subfamily, causing exanthema subitum and encephalitis.
Hirai M +5 more
europepmc +4 more sources
DNA Sensors’ Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection [PDF]
Frontiers in Microbiology, 2020 ObjectivesThe host DNA sensor proteins TLR9, STING, IFI16 are central signaling molecules that control the innate immune response to cytosolic nucleic acids. Here we propose to investigate how Natural killer (NK) cell infection by human herpesvirus (HHV)-
Daria Bortolotti +11 more
doaj +3 more sources
Evaluation of a method to measure HHV-6B infection in vitro based on cell size. [PDF]
Virol J, 2018 Human herpesvirus 6 (HHV-6A and HHV-6B) infection of cell cultures can be measured by different methods, including immunofluorescence microscopy, flow cytometry, or quantification of virus DNA by qPCR. These methods are reliable and sensitive but require
Becerra-Artiles A, Santoro T, Stern LJ.
europepmc +7 more sources
HHV-6B- and HHV-7-associated choroiditis secondary to acute myelogenous leukemia: a case report. [PDF]
J Int Med Res, 2023 We report a case of human herpes virus 6 (HHV-6)- and human herpes virus 7 (HHV-7)-associated choroiditis in an immunocompromised woman. A 42-year-old Chinese woman with a history of acute myelogenous leukemia presented with blurred vision and black ...
Xu J, Chen L, Cen T, Zeng Y, Liu Q.
europepmc +2 more sources
The clinical and epidemiological features of HHV-6A and HHV-6B infections in children of Moscow
Детские инфекции (Москва), 2019 Human herpes virus type 6 (HHV-6) is the etiological agent of plenty diseases. The form of the developing pathology depends on the localization of the virus in T-lymphocytes and on virus type: HHV-6A or HHV-6B, but identification of the type is possible ...
M. Yu. Lysenkova +11 more
doaj +4 more sources
Impact of HHV-6A and HHV-6B lytic infection on autophagy and endoplasmic reticulum stress.
Journal of General Virology, 2019 Herpesviruses are known to manipulate autophagy to optimize their replication, counteract immune response and probably to promote tumourigenesis.
M. Romeo +7 more
semanticscholar +5 more sources