Results 161 to 170 of about 78,725 (202)

Title: Latent, early or late HHV-6B expression in adult mesial temporal lobe epilepsy: Association of virus life cycle with inflammatory cytokines in brain tissue and cerebral spinal fluid.

Neuroscience, 2022
BACKGROUND Human herpes virus-6B (HHV-6B) was suggested as an important etiologic factor of mesial temporal lobe epilepsy, while the mechanism is still unknown.
Jia-Qi Wang, Hong-Yu Yang, Xue-qing Shao, Xin-Yue Jiang, Jin-Mei Li   +4 more
semanticscholar   +1 more source

Unique cell tropism of HHV‐6B in an infantile autopsy case of primary HHV‐6B encephalitis

Neuropathology, 2018
Human herpes virus 6 (HHV‐6) is known to cause primary encephalitis in the frontal lobes/cerebral hemisphere or reactivated encephalitis in the hippocampus, but the pathogenesis remains unclear. HHV‐6B has also been detected in hippocampal samples in patients with mesial temporal lobe epilepsy.
Hiroaki Miyahara, Kouki Miyakawa, Haruto Nishida, Shinji Yano, Tomoko Sonoda, So‐ichi Suenobu, Tatsuro Izumi, Tsutomu Daa, Kenji Ihara   +8 more
openaire   +2 more sources

Glycoproteins of HHV-6A and HHV-6B

2018
Recently, human herpesvirus 6A and 6B (HHV-6A and HHV-6B) were classified into distinct species. Although these two viruses share many similarities, cell tropism is one of their striking differences, which is partially because of the difference in their entry machinery.
Huamin, Tang, Yasuko, Mori
openaire   +2 more sources

Serum biomarker kinetics with three different courses of HHV-6B encephalitis

Brain and Development, 2013
Human herpesvirus-6B (HHV-6B) encephalitis can clinically manifest as hemorrhagic shock and encephalopathy syndrome (HSES), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), and acute necrotizing encephalopathy (ANE). To compare the underlying pathophysiology, we measured several biomarkers of interest in patients with ...
Yoshiki, Kawamura, Hidetaka, Nakai, Ken, Sugata, Yoshizo, Asano, Tetsushi, Yoshikawa   +4 more
openaire   +2 more sources

Persistent hyponatremia as a distinctive feature of HHV-6B encephalitis in pediatric hematopoietic stem cell transplant recipients: A case series

Blood
Background: Electrolyte imbalances are a common complication in the context of transplantation, generally presenting as mild and responding well to timely symptomatic management.
Xiao-Lan Li, Yang Wan, Li-Peng Liu, Ao-Li Zhang, Xiao-Yan Zhang, Xia Chen, Yuan-Yuan Ren, Ye Guo, Xiao-Fan Zhu, Wen-Yu Yang, Fang Liu   +10 more
semanticscholar   +1 more source

The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary monocytes infected by HHV-6B.

Virus Research, 2020
Programmed death ligand 1 (PD-L1) up-regulation on antigen presenting cells induces T cell dysfunction, strongly impairing immune response. Human Herpesviruses (HHV) 6B is a β-herpesvirus that, although displays a higher tropism for T cells, can infect ...
M. Romeo, M. S. Gilardini Montani, Rossella Benedetti, L. Giambelli, Rosella D'Aprile, A. Gaeta, A. Faggioni, M. Cirone   +7 more
semanticscholar   +1 more source

Single-cell RNA sequencing reveals distinct immune interaction networks in primary and reactivated HHV-6B infection.

Journal of Infectious Diseases
BACKGROUND Human herpesvirus 6B (HHV-6B) infection causes clinically distinct diseases in primary infection or viral reactivation. Primary infection manifests as exanthem subitum (ES), a common childhood febrile exanthem; whereas reactivation is ...
Yoshiki Kawamura, Y. Sato, Yusuke Tsumura, M. Wakamatsu, Shiori Endo, Takako Suzuki, Yotaro Kondo, Masato Itano, Hiroki Miura, Y. Higashimoto, M. Ihira, Yusuke Okuno, Hiroshi Kimura, Tetsushi Yoshikawa, Jun-Ichi Kawada   +14 more
semanticscholar   +1 more source

Clinical Impact of HHV-6B Reactivation on Engraftment and Outcomes Following Allogeneic Hematopoietic Stem Cell Transplantation.

Transplantation and Cellular Therapy
BACKGROUND Human herpesvirus 6B (HHV-6B) reactivation is a recognized event following allogeneic hematopoietic stem cell transplantation (HSCT). However, its impact on engraftment kinetics and post-transplant outcomes remains incompletely defined ...
S. M. Hosseini-Moghaddam, R. Johnstone, Tony Mazzulli, M. Remberger, I. Pašić, J. Mattsson, Ferdous Parveen, Carol Chen, S. Husain, Florence Runyo, F. Michelis   +10 more
semanticscholar   +1 more source

HHV-6B reduces autophagy and induces ER stress in primary monocytes impairing their survival and differentiation into dendritic cells.

Virus Research, 2019
HHV-6A and HHV-6B are ubiquitous human betaherpesviruses sharing more than 80% homology. HHV-6B is the most common cause of encephalitis in transplant patients and its primary infection may cause the exanthema subitum and febrile seizures in infants. HHV-
M. Romeo, M. S. Gilardini Montani, Luca Falcinelli, A. Gaeta, C. Nazzari, A. Faggioni, M. Cirone   +6 more
semanticscholar   +1 more source

Non‐paraneoplastic limbic encephalitis and central nervous HHV‐6B reactivation: Causality or coincidence?

Neuropathology, 2016
Autoantibody‐related encephalopathies represent an important differential diagnosis in adult onset epilepsy. Here, we report the case of a 25‐year‐old patient with new‐onset epilepsy and psychotic syndrome, who underwent biopsy resection for etiological classification.
Pitt, Niehusmann, Guido, Widman, Anna M, Eis-Hübinger, Susanne, Greschus, Barbara K, Robens, Alexander, Grote, Albert J, Becker   +6 more
openaire   +2 more sources