Results 61 to 70 of about 150,809 (224)

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Comparative analysis of multiple cell culture models. The 3D microfluidic organ‐on‐a‐chip, which is superior to the existing models in multiple aspects, can be more conducive to new studies and discoveries related to human beings. Created with BioRender (www.biorender.com).
Xuxia Cao, Congmin Xia, Caifeng Li, Shiwen Deng, Junxian Cao, Hongjun Yang, Shaoping Wang, Peng Chen   +7 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Cardiovascular magnetic resonance myocardial feature tracking detects quantitative wall motion during dobutamine stress

Journal of Cardiovascular Magnetic Resonance, 2011
Background Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis is typically based on visual assessment with considerable operator dependency.
Beerbaum Philipp, Bigalke Boris, Makowski Marcus R, Parish Victoria, Gribben Paul, Danford David A, Kutty Shelby, Padiyath Asif, Schuster Andreas, Nagel Eike   +9 more
doaj   +1 more source

Vat photopolymerization‐based bioprinting: Shaping next‐generation tissues with light

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
Vat photopolymerization‐based bioprinting is revolutionizing biofabrication by enabling high‐precision construction of biological structures. This review systematically examines photopolymerization mechanisms and variants in printing techniques, discusses design principles and composition of bio‐inks, and highlights recent progress toward next ...
Wei Long Ng, Carlos T. B. Paula, Arménio C. Serra, Jorge F. J. Coelho, Paulo Bartolo   +4 more
wiley   +1 more source

Myocardial feature tracking reduces observer-dependence in low-dose dobutamine stress cardiovascular magnetic resonance.

PLoS ONE, 2015
ObjectivesTo determine whether quantitative wall motion assessment by CMR myocardial feature tracking (CMR-FT) would reduce the impact of observer experience as compared to visual analysis in patients with ischemic cardiomyopathy (ICM).Methods15 ...
Andreas Schuster, Matthias Paul, Nuno Bettencourt, Shazia T Hussain, Geraint Morton, Shelby Kutty, Boris Bigalke, Amedeo Chiribiri, Divaka Perera, Eike Nagel, Philipp Beerbaum   +10 more
doaj   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 58-72, January 2026.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Cardiovascular biomarkers and preeclampsia: A narrative review

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Preeclampsia (PE) is a complex pregnancy disorder linked to cardiovascular disease (CVD) through shared risk factors and epidemiological associations. Cardiovascular biomarkers are valuable for predicting, diagnosing and assessing PE, as well as estimating future CVD risk. This review explores current cardiovascular biomarkers used in clinical practice
Johana Ullmo, Madalina Nicoleta Nan, Mónica Cruz‐Lemini, Carmen Garrido‐Gimenez, Judit Platero, Álvaro García‐Osuna, Pablo García‐Manau, Marcel Twickler, Elisa Llurba   +8 more
wiley   +1 more source

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
wiley   +1 more source

Prediction of long-term segmental and global functional recovery of hibernating myocardium after revascularisation based on low dose dobutamine and late gadolinium enhancement cardiovascular magnetic resonance

Journal of Cardiovascular Magnetic Resonance, 2014
BackgroundThis study sought to evaluate the relation between long-term segmental and global functional outcome after revascularisation in patients with chronic ischaemic left ventricular dysfunction (LVD) and baseline markers of viability: late ...
S. Glaveckaitė, N. Valevičienė, D. Palionis, R. Puronaitė, P. Serpytis, A. Laucevičius   +5 more
semanticscholar   +1 more source