Results 71 to 80 of about 150,809 (224)

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source

Re‐PERFUSE: Phase 1b study of AZD3427, a novel relaxin receptor agonist, on renal perfusion in HFrEF patients

ESC Heart Failure, Volume 12, Issue 6, Page 4495-4502, December 2025.
Abstract Aims Renal impairment frequently coexists with heart failure (HF) and is associated with increased risk of poor clinical outcomes. This highlights the urgent need for therapies targeting both cardiac and renal dysfunction. AZD3427, a long‐acting recombinant fusion protein and relaxin analogue that selectively activates the relaxin family ...
Marcin Ufnal, Macarena P. Quintana‐Hayashi, Kathleen Connolly, Daniel Pettersen, Zsolt Cselényi, Aurelija Jucaite, Magnus Schou, Andrea Varrone, Melanie Chan, Lars H. Lund   +9 more
wiley   +1 more source

Effects of hibernation on two important contractile tissues in tibetan frogs, Nanorana parkeri: a perspective from transcriptomics and metabolomics approaches

BMC Genomics
Background In response to seasonal cold and food shortage, the Xizang plateau frogs, Nanorana parkeri (Anura: Dicroglossidae), enter a reversible hypometabolic state where heart rate and oxygen consumption in skeletal muscle are strongly suppressed ...
Yonggang Niu, Xuejing Zhang, Shengkang Men, Tisen Xu, Haiying Zhang, Xiangyong Li, Kenneth B. Storey, Qiang Chen   +7 more
doaj   +1 more source

MP-453090-11 HIBERNATING MYOCARDIUM IS ASSOCIATED WITH A LOWER INCIDENCE OF SUSTAINED VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY [PDF]

, 2023
Boldizsar Kovacs, Dominik C. Benz, Valon Gllareva, Frank Ruschitzka, Fırat Duru, Philipp A. Kaufmann, Ronny R. Buechel, Ardan M. Saguner   +7 more
openalex   +1 more source

Guideline‐directed medical therapy after revascularization and outcomes in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 6, Page 4442-4450, December 2025.
Among patients with ischaemic heart failure undergoing revascularisation, those receiving GDMT had lower unadjusted mortality rates. The combination of GDMT and CABG was associated with the best long‐term outcomes. In real‐world practice, the use of GDMT increased over time, reflecting a growing emphasis on guideline‐based therapy even after ...
Carlos Moliner‐Abós, Maria Calvo‐Barceló, Eduard Solé‐Gonzalez, Andrea Borrellas Martín, Paula Fluvià Brugués, Jesus Sánchez Vega, Joan Vime Jubany, Maria Ferré Vallverdú, Manel Taurón Ferrer, Pablo Eduardo Tobias Castillo, Juan Carlos de la Fuente Mancera, Pau Vilardell Rigau, Rosa Vila Olives, Carles Diez López, Antoni Bayés‐Genís, Dabit Arzamendi Aizpurua, Ignacio Ferreira González, Sònia Mirabet Pérez   +17 more
wiley   +1 more source

Myocardial cytoprotection and ischemic myocardial dysfunction correction in stable angina patients after transluminal balloon angioplasty or coronary artery stenting

Российский кардиологический журнал, 2006
The results of myocardial cytoprotection with mildronate and trimethazidine (Preductal MB) in stable angina patients with left ventricular (LV) myocardial dysfunction, including hibernation, are presented.
I. G. Gordeev, V. A. Lusov, E. A. Bekchiu, N. A. Volov, E. E. Ilina, A. Yu. Lebedeva   +5 more
doaj  

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Systemic muscle wasting is a prevalent condition that predicts adverse health outcomes in aging and disease. Despite its clinical relevance, the development of predictive biomarkers and effective pharmacological therapies remains limited. Peptides have recently gained attention for their diverse bioactive functions, positioning them
Petar Naumovski, Bart De Spiegeleer, Aster Wakjira, Christophe Van De Wiele, Vincent Mouly, Katarzyna Goljanek‐Whysall, Kauê Santana da Costa, Ewerton Cristhian Lima de Oliveira, Evelien Wynendaele, Anton De Spiegeleer   +9 more
wiley   +1 more source

Changes in local left and right ventricular myocardial contractility in patients with recurrent atrial fibrillation

Кардиоваскулярная терапия и профилактика, 2006
Aim. To evaluate local contractility of left and right ventricular (LV, RV) myocardium, as well as its dynamics in acute drug test (AMT) with nitroglycerin (NG) in patients with recurrent atrial fibrillation (AF), during sinus rhythm maintenance period ...
I. G. Fomina, N. E. Gaidamakina, A. I. Tarzimanova   +2 more
doaj  

P‐Wave Parameter Changes After Pulsed‐Field Ablation, Cryoballoon Ablation and Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: An Observational Cohort Study

Journal of Arrhythmia, Volume 41, Issue 6, December 2025.
Pulsed‐field ablation, radiofrequency, and cryoballoon ablation produced similar acute changes in P‐wave indices on surface ECG. Increased post‐procedural P‐wave duration was the only robust predictor of atrial fibrillation recurrence, highlighting its prognostic value across modalities despite the limited sensitivity of body surface ECG for modality ...
Ibrahim Antoun, Ahmed Abdelrazik, Xin Li, Mahmoud Eldesouky, Kaung Myat Thu, Riyaz Somani, G. André Ng   +6 more
wiley   +1 more source

Long-term preservation of myocardial energetic in chronic hibernating myocardium.

Am J Physiol Heart Circ Physiol, 2011
Jameel MN, Li Q, Mansoor A, Xiong Q, Swingen C, Zhang J.   +5 more
europepmc   +2 more sources