Results 41 to 50 of about 635,362 (294)

scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution

Genome Biology, 2021
High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task.
Chantriolnt-Andreas Kapourani, Ricard Argelaguet, Guido Sanguinetti, Catalina A. Vallejos   +3 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

LOCALIZED DATA FOR EDUCATIONAL EQUITY: SMALL AREA ESTIMATION OF OUT-OF-SCHOOL CHILDREN IN BALI AND NUSA TENGGARA

Barekeng
This study aims to estimate the percentage of out-of-school children aged 7–17 years in Bali and Nusa Tenggara using the Small Area Estimation (SAE) method with a Hierarchical Bayes.
Sherina Rafidah Khairunnisa, Azka Ubaidillah, Ahmad Sovi Hidayat, Alya Nur Septiyana, Shalihati Melani Putri, Ahmad Tegar Prananggalih, Arya Candra Kusuma, Shafiyah Asy Syahidah   +7 more
doaj   +1 more source

Empirical E-Bayesian estimation of hierarchical poisson and gamma model using scaled squared error loss function

Alexandria Engineering Journal, 2023
The hierarchical models have not only a major concern with developing computational schemes but also assist in inferring the multi-parameter problems.
Azeem Iqbal, Muhammad Yousaf Shad, Mansour F. Yassen   +2 more
doaj   +1 more source

Hierarchical Bayesian sparse image reconstruction with application to MRFM [PDF]

, 2008
This paper presents a hierarchical Bayesian model to reconstruct sparse images when the observations are obtained from linear transformations and corrupted by an additive white Gaussian noise. Our hierarchical Bayes model is well suited to such naturally
Hero, Alfred O., Dobigeon, Nicolas, Tourneret, Jean-Yves   +2 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Bayes linear kinematics in the analysis of failure rates and failure time distributions [PDF]

, 2010
Collections of related Poisson or binomial counts arise, for example, from a number of different failures in similar machines or neighbouring time periods.
Farrow, Malcolm, Wilson, Kevin
core   +4 more sources

SMALL AREA ESTIMATION OF CHILD UNDERNOURISHMENT PREVALENCE IN BALI AND NUSA TENGGARA

Barekeng
Children under the age of 17 are particularly prone to undernutrition. Undernutrition can impair children’s growth and development. In the process of policy formulation, it is necessary to calculate a reliable estimate of the prevalence of child ...
Amalia Ndaru Nuriyo, Huda Muhammad Fajar, Jeremia Novaldi, Meautia Rahmi, Sabrina Do Miswa, Cucu Sumarni   +5 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Empirical Bayes methodology for estimating equipment failure rates with application to power generation plants [PDF]

, 2008
Many reliability databases pool event data for equipment across different plants. Pooling may occur both within and between organizations with the intention of sharing data across common items within similar operating environments to provide better ...
Hutchison, Kenneth, Raza, M., Walls, L.A., Quigley, John   +3 more
core   +4 more sources