Results 141 to 150 of about 387,064 (296)
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
An LEO Constellation Early Warning System Decision-Making Method Based on Hierarchical Reinforcement Learning. [PDF]
Sensors (Basel), 2023 Cheng Y, Wei C, Sun S, You B, Zhao Y.
europepmc +1 more source
Advanced Science, EarlyView.Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi +5 more
wiley +1 more source
Hierarchical Reinforcement Learning, Sequential Behavior, and the Dorsal Frontostriatal System. [PDF]
J Cogn Neurosci, 2022 Janssen M +3 more
europepmc +1 more source
Subgoals in Hierarchical Reinforcement Learning
Hierarchy is an important feature of efficient cognition, including learning and reasoning. In the hierarchical reinforcement learning framework, complex learning problems are decomposed into sub-components that lead to subgoals; subgoals can, in turn, be flexibly combined and used to solve a problem in the absence of immediate rewards.
Milena Rmus +2 more
openaire +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Hierarchical & Factored Reinforcement Learning
, 2010 Cette thèse a été réalisée dans un contexte de simulation industrielle qui s'intéresse aux problèmes de la modélisation du comportement humain dans les simulateurs d'entraînement militaire ou de sécurité civile. Nous avons abordé cette problématique sous l'angle de l'apprentissage et de la planification dans l'incertain, en modélisant les problèmes que
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Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang +12 more
wiley +1 more source
Toward an Adaptive Threshold on Cooperative Bandwidth Management Based on Hierarchical Reinforcement Learning. [PDF]
Sensors (Basel), 2021 Mobasheri M, Kim Y, Kim W.
europepmc +1 more source
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Advanced Science, EarlyView.Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source