Results 91 to 100 of about 1,344,275 (293)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Thermodynamically consistent concurrent material and structure optimization of elastoplastic multiphase hierarchical systems. [PDF]
Struct Multidiscipl Optim, 2023 Gangwar T, Schillinger D.
europepmc +1 more source
Constructing Hierarchical Rule Systems [PDF]
, 2003 Rule systems have failed to attract much interest in large data analysis problems because they tend to be too simplistic to be use- ful or consist of too many rules for human interpretation. We present a method that constructs a hierarchical rule system, with only a small number of rules at each stage of the hierarchy.
Gabriel, Thomas R., Berthold, Michael R.
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Concurrent material and structure optimization of multiphase hierarchical systems within a continuum micromechanics framework. [PDF]
Struct Multidiscipl Optim, 2021 Gangwar T, Schillinger D.
europepmc +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Hierarchical Scaling in Systems of Natural Cities
Entropy, 2018 Hierarchies can be modeled by a set of exponential functions, from which we can derive a set of power laws indicative of scaling. The solution to a scaling relation equation is always a power law.
Yanguang Chen, Bin Jiang
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
PLAYOUT — A Hierarchical Layout System [PDF]
, 1988 Very Large Scale Intergration (VLSI) has become a technology of large economical importance. Mastering of this technology on one hand means the latest semiconductor processing technology, on the other hand computer aided design. Whereas the first is a problem for physics and chemistry, the progress in the second field results from large activities in ...
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