Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Hierarchical games and their applications in reasoning about reactive systems
We present a unified game-based approach for branching-time model checking of hierarchical systems. Such systems are exponentially more succinct than standard state-transition graphs, as repeated sub-systems are described only once.
MURANO, ANIELLO, O. Kupferman
core
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
A hierarchical multi-label classification ant colony algorithm for protein function prediction [PDF]
This paper proposes a novel ant colony optimisation (ACO) algorithm tailored for the hierarchical multi-label classification problem of protein function prediction.
Otero, Fernando E.B. +5 more
core +1 more source
Hierarchical Blockchain Energy Trading Platform and Microgrid Management Optimization
In this paper, we describe a solution that has been developed to create an intelligent software platform for the optimal management of energy trade (specifically a P2P trade) in microgrids.
Kristián Košt’ál +2 more
doaj +1 more source
Multiple parallel fuzzy expert systems utilizing a hierarchical fuzz model
Business, economic, and agricultural YES-or-NO decision making problems often require multiple, different and specific expertises. This is due to the nature of such problems in which decisions may be influenced by multiple different, relevant aspects ...
S. Aly, I. Vrana
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Hierarchical location-allocation models for congested systems [PDF]
In this paper we address the issue of locating hierarchical facilities in the presence of congestion. Two hierarchical models are presented, where lower level servers attend requests first, and then, some of the served customers are referred to higher ...
Daniel Serra, Vladimir Marianov
core
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
A hierarchical coordinated control strategy of air‐conditioning loads for peak regulation service
The increased penetration of renewable energy sources and the intensification of peak‐valley differences present challenges to peak regulation in the power system.
Wei Wang +7 more
doaj +1 more source

