Results 61 to 70 of about 275,491 (268)
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Hierarchical Blockchain Energy Trading Platform and Microgrid Management Optimization
EnergiesIn this paper, we describe a solution that has been developed to create an intelligent software platform for the optimal management of energy trade (specifically a P2P trade) in microgrids.
Kristián Košt’ál +2 more
doaj +1 more source
Multiple parallel fuzzy expert systems utilizing a hierarchical fuzz model
Agricultural Economics (AGRICECON), 2007 Business, economic, and agricultural YES-or-NO decision making problems often require multiple, different and specific expertises. This is due to the nature of such problems in which decisions may be influenced by multiple different, relevant aspects ...
S. Aly, I. Vrana
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Constructing Hierarchical Rule Systems [PDF]
, 2003 Rule systems have failed to attract much interest in large data analysis problems because they tend to be too simplistic to be use- ful or consist of too many rules for human interpretation. We present a method that constructs a hierarchical rule system, with only a small number of rules at each stage of the hierarchy.
Gabriel, Thomas R., Berthold, Michael R.
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
A hierarchical coordinated control strategy of air‐conditioning loads for peak regulation service
IET Generation, Transmission & DistributionThe increased penetration of renewable energy sources and the intensification of peak‐valley differences present challenges to peak regulation in the power system.
Wei Wang +7 more
doaj +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Thermodynamically consistent concurrent material and structure optimization of elastoplastic multiphase hierarchical systems. [PDF]
Struct Multidiscipl Optim, 2023 Gangwar T, Schillinger D.
europepmc +1 more source