Results 61 to 70 of about 9,650,037 (303)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Hierarchical task analysis: Developments, applications and extensions [PDF]
, 2006 Hierarchical Task Analysis (HTA) is a core ergonomics approach with pedigree of over thirty years continuous use. At its heart, HTA is based upon a theory of performance and has only three governing principles.
Stanton, Neville A., Stanton, NA
core +1 more source
Order reduction of hierarchical interconnected dynamical systems [PDF]
Advances in Radio Science, 2018 The simulation of large scale nonlinear dynamical interconnected systems, as they arise in all modern engineering disciplines, is a usual task. Due to the high complexity of the considered systems, the principle of thinking in hierarchical structures ...
M. Popp, W. Mathis
doaj +1 more source
Frontiers in Public Health, 2022 BackgroundIn order to maintain high standards of healthcare, it is necessary for medical departments to provide high-quality and affordable medical services to local residents.
Chen Liang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
A Hierarchical Classification of Farm Systems
Experimental Agriculture, 1988 SummaryA framework is proposed for the classification of farm systems, which are defined as decisionmaking units comprising farm household, cropping and livestock systems that transform land, capital and labour into products for consumption and sale. Two general principles underlying the classification are outlined.
Fresco, L.O., Westphal, E.
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Towards Energy-aware Multiprocessor Hierarchical Scheduling of Real-time Systems
, 2013 Multiprocessor platforms are becoming increasingly more popular. Providing more computation capacity on a single hardware platform, multiprocessors make it possible to integrate previously federated real-time systems onto a single platform ...
Moghaddami Khalilzad, Nima, +3 more
core +7 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source