Results 181 to 190 of about 29,837,368 (252)

Acalypha australis L. induces autophagic cell death in colorectal cancer cells by increasing ROS through suppression of the AKT/mTOR/HIF-1 pathway. [PDF]

Front Oncol
Du C, Li J, Zhou K, Sun H, Liang A, Tan R, Zhai J, Huang W, Yang B, Tang D.   +9 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Computational biological analysis reveals that HIF-1 and FoxO signaling pathways influence cognitive impairment in patients with depression. [PDF]

Transl Psychiatry
Zhuo C, Zhang Y, Zhang Q, Yang L, Chen X, Ma X, Li R, Wang L, Tian H, Mao F.   +9 more
europepmc   +1 more source

Multifunctional hyaluronic acid hydrogel integrating exosome‐encapsulating gelatin microspheres accelerates skeletal muscle regeneration via TGF‐β1 activation and enhanced myogenic cell viability

BMEMat, EarlyView.
Schematic illustration of preparation of injectable H/G@Co@miR‐206 hydrogel for efficient skeletal muscle regeneration in cardiotoxin‐induced skeletal muscle injury SD rat model. Abstract The effective treatment of acute skeletal muscle injuries remains challenging, necessitating therapeutic strategies that concurrently reestablish vascular perfusion ...
Zhengzhe Han, Zongyue Li, Ang Li, Zheng Jiang, Saiyu Shi, Zhipeng Wang, Jishizhan Chen, Yun Qian, Yuanyang Gu, Xianyou Zheng   +9 more
wiley   +1 more source

HIF-1 and DEC-1 levels in acute ischaemic stroke patients: Could DEC-1 be a new biomarker in stroke? [PDF]

Biomed J
Demirdöğen F, Bilge N, Eren A.
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

A warming-yang herbal decoction protects against high-altitude hypoxia-induced osteoblast injury through modulation of HIF-1 signaling. [PDF]

Front Pharmacol
Liu X, Qi Y, Zhao R, Jia B, Lei X, Li H, Wang D, Zhang H, Wang W, Song Z.   +9 more
europepmc   +1 more source

Homologous tumor‐targeting biomimetic nanozyme for synergistic NIR‐II photothermal and chemodynamic therapy

BMEMat, EarlyView.
Studies reveal that a biomimetic nanoplatform based on a cancer cell membrane‐camouflaged Au‐MnOx nanozyme (Au‐MnOx@CCM) can achieve synergistic antitumor therapy by combining NIR‐II mediated PTT with enhanced CDT, offering a promising strategy for precise and efficient tumor therapy. Abstract The therapeutic potential of nanozyme‐mediated chemodynamic
Xiaonan Li, Siman Luo, Yucheng Zuo, Liheng Chen, Houjuan Zhu, Jing‐Yi Zhu, Wei Xue   +6 more
wiley   +1 more source

Epitranscriptomic regulation of HIF-1: bidirectional regulatory pathways. [PDF]

Mol Med
Benak D, Alanova P, Holzerova K, Chalupova M, Opletalova B, Kolar F, Pavlinkova G, Hlavackova M.   +7 more
europepmc   +1 more source

Recent Update of Natural Compounds as HIF-1α Inhibitors in Colorectal Carcinoma

Pratibha Pandey,1,2 Sorabh Lakhanpal,3 Danish Mahmood,4 Lalji Baldaniya,5 Han Na Kang,6 Sungho Hwang,7 Sojin Kang,7 Min Choi,7 Seungjoon Moon,7 Shivam Pandey,8 Kamlesh Chaudhary,9 Fahad Khan,10 Bonglee Kim6,7 1Centre for Research Impact & Outcome ...
Kang HN, Moon S, Kim B, Hwang S, Kang S, Pandey P, Chaudhary K, Choi M, Pandey S, Mahmood D, Khan F, Baldaniya L, Lakhanpal S   +12 more
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