Results 211 to 220 of about 29,837,368 (252)

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

HIF-1 promotes murine breast cancer brain metastasis by increasing production of integrin β3-containing extracellular vesicles. [PDF]

J Clin Invest
Yang Y, Chen C, Lyu Y, Gololobova O, Guo X, Huang TY, Ramu V, Talwar V, Wicks EE, Salman S, Drehmer D, Dordai D, Zuo Q, Witwer KW, Gabrielson KL, Semenza GL.   +15 more
europepmc   +1 more source

Variance‐Empirical Mode Decomposition Method for Fault Detection in MMC‐HVDC Transmission Lines

Energy Science &Engineering, EarlyView.
A variance‐embedded empirical mode decomposition (VEMD) method is proposed for fast and accurate fault detection in MMC‐HVDC transmission lines. By combining variance analysis with EMD, the method reliably detects various faults without communication links and remains robust to noise and non‐fault transients.
Seyed Amir Hosseini, Behrooz Taheri
wiley   +1 more source

ERBB2 mutations promote recurrence and metastasis in non-muscle-invasive bladder cancer via HIF-1 phosphorylation: Insights from whole exome sequencing. [PDF]

J Pharm Anal
Wang X, Jin L, Zou X, Zhu A, Li M, Fan H.   +5 more
europepmc   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

The role of lipids in promoting hair growth through HIF-1 signaling pathway. [PDF]

Sci Rep
Seo J, Matsumoto K, Nanmo A, Tu S, Jeong DW, Chun YS, Yan L, Kageyama T, Fukuda J.   +8 more
europepmc   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF-1 Pathway in Polycystic Ovary Syndrome. [PDF]

Adv Sci (Weinh)
Wang G, Mao W, Zhang Y, Yang H, Zhu M, Li Y, Chen W, Chen Y, Lou C, Li P, Chang HM, Yuan S, Zhao Y, Mu L.   +13 more
europepmc   +1 more source

Hypoxia and HIF-1 inhibition enhance lentiviral transduction efficiency: a novel strategy for gene delivery optimization. [PDF]

BMC Biotechnol
Huo Q, Wang W, Dai J, Yuan X, Yu D, Xu B, Chi Y, Li H, Pei XL, Zhu G, Zhang L.   +10 more
europepmc   +1 more source