Results 61 to 70 of about 29,837,368 (252)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. [PDF]
, 2015 International audienceHelicobacter pylori infection triggers chronic inflammation of the gastric mucosa that may progress to gastric cancer. The hypoxia-inducible factors (HIFs) are the central mediators of cellular adaptation to low oxygen levels ...
Mathieu, Jacques R. R. +27 more
core +1 more source
Advanced Functional Materials, EarlyView.Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro +25 more
wiley +1 more source
Contribution of hypoxia inducible factor-1 during viral infections
Virulence, 2020 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes +5 more
doaj +1 more source
Mouse models for preeclampsia: disruption of redox-regulated signaling [PDF]
, 2009 The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-Omethyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia ...
Chambers, Anne E. +8 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma +13 more
wiley +1 more source
Reproductive Biology and Endocrinology, 2012 Background Spermatic cord torsion can lead to testis ischemia (I) and subsequent ischemia-reperfusion (I/R) causing germ cell-specific apoptosis.
Palladino Michael A +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn +6 more
wiley +1 more source
Hypoxia regulated pathways in urological malignancies
, 2009 Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses inthe UK each year. Patient survival has improved over the past few decades; however themechanisms of this are yet to be fully elucidated.
Charlesworth, Philip J.S. +1 more
core +1 more source
Сибирский онкологический журнал, 2016 The aim of the study was to investigate the NF-κB, HIF-1 and VEGF expressions and the proteasome and calpain activities in localized and disseminated kidney cancers.Material: The study included 87 patients with clear cell kidney cancer.
L. V. Spirina +4 more
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