Results 71 to 80 of about 29,837,368 (252)
HIF-GC crosstalk-DM Poster.pdf
, 2020 Hypoxia is a pathophysiological condition to which cells rapidly respond via the activity of Hypoxia-Inducible Factors (HIFs) in order to restore homeostasis and to prevent metabolic shutdown. It can be maladaptive and contributes to inflammation, tissue
Freek J. van Eeden (401568) +5 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Известия высших учебных заведений. Поволжский регион: Медицинские наукиBackground. Currently, in the field of molecular genetic research, the study of gene polymorphisms remains relevant. These studies are being conducted to identify a person’s genetic predisposition to various diseases, which can subsequently be used to ...
Kira Yu. Pankina +3 more
doaj +1 more source
Regulation of the Rgs4 gene by the hypoxia inducible factors. [PDF]
, 2012 The transcriptional response to hypoxia is critically dependent on the Hypoxia Inducible Factors HIF-1 and HIF-2, which have roles not only in development and cellular adaptation to low oxygen levels, but also in diseases such as cancer.
Olechnowicz, Sam
core
Advanced Science, EarlyView.The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng +15 more
wiley +1 more source
PLoS Biology, 2004 The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (HIF).
Tammie Bishop +10 more
doaj +1 more source
HIF-1 and VEGF expression levels.
, 2019 SS: sham + sedentary; ST: sham + exercise training; IS: acute MI + sedentary; IT: acute MI + exercise training. Panel A: Hypoxia inducible factor (HIF-1), p (interaction) = 0.032. Panel B: vascular endothelial growth factor (VEGF), though the interaction
Rafael Aguiar Marschner (7378154) +5 more
core +1 more source
Advanced Science, EarlyView.Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang +10 more
wiley +1 more source