STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient
Hypobaric hypoxia elicits several patho-physiological manifestations, some of which are known to be lethal. Among various molecular mechanisms proposed so far, perturbation in redox state due to imbalance between radical generation and antioxidant ...
Subhojit Paul +3 more
doaj +1 more source
Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion. [PDF]
Under acute hypoxic conditions, the muscle oxygen uptake (mV˙O2) during exercise is reduced by the restriction in oxygen-supplied volume to the mitochondria within the peripheral tissue. This suggests the existence of a factor restricting the mV˙O2 under
Furuichi, Yasuro +7 more
core +1 more source
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia +7 more
wiley +1 more source
Effects of exposure to altitude on neuropsychology aspects: a literature review [PDF]
OBJECTIVE: Discuss the effects of altitude exposure on neuropsychological functions. METHOD: We have conducted a literature review using as source indexed articles at Pubmed in the period from 1921 to 2008, using the following key words: cognition and ...
Antunes, Hanna Karen Moreira +5 more
core +1 more source
Pan‐genome analysis reveals that high‐altitude Rhododendron species resist alpine cold stress by rapidly sensing and engaging the chilling response pathway and genes that directly and indirectly protect the plant from UV radiation. Heritable genomic features such as long terminal repeats contribute to the adaptive diversification of Rhododendron ...
Haoyang Zhou +11 more
wiley +1 more source
Impact of Environmental Exposure on Infant Sleep : The Exposome Approach
This review explores how exposure to environmental pollutants during the first 1000 days of life may affect infant sleep. Evidence suggests potential links between chemical exposures and sleep disturbances, underscoring the need for more research on early‐life vulnerability and the impact of pollutants in air, diet, and breast milk.
Zeina Halbouty +6 more
wiley +1 more source
Changes in labial capillary density on ascent to and descent from high altitude. [PDF]
Present knowledge of how the microcirculation is altered by prolonged exposure to hypoxia at high altitude is incomplete and modification of existing analytical techniques may improve our knowledge considerably.
Coppel, J +5 more
core +8 more sources
Post-exercise parasympathetic reactivation and sensibility to hypoxia [PDF]
Introduction Exposure to hypoxia leads to several reactions of the organism, which try to compensate the reduced oxygen level in the blood. Acute response is characterized by an increase in pulmonary ventilation (Hypoxia Ventilatory Response, HVR) and in
Leuzinger, M.
core
Optimizing Cycle Exercise Performance During Normobaric Hypoxia Exposure
Introduction: The purpose of the present study was to examine whether implementing factors of OPTIMAL Theory: Enhanced Expectancies (EE), Autonomy Support (AS), and External Focus (EF) during a cycle exercise bout at a simulated altitude of 21,000 feet ...
Ugale, Cierra Brittany
core +1 more source
Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia
ABSTRACT Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude‐related physiological differences may influence these parameters. Studying adolescents at different very high altitudes is crucial, as subtle environmental variations could affect sleep‐related oxygenation and ...
Keaton Patterson +8 more
wiley +1 more source

