Results 41 to 50 of about 34,730 (280)

Introgressive Hybridization and Hypoxia Adaptation in High-Altitude Vertebrates [PDF]

Frontiers in Genetics, 2021
In natural populations of animals, a growing body of evidence suggests that introgressive hybridization may often serve as an important source of adaptive genetic variation. Population genomic studies of high-altitude vertebrates have provided strong evidence of positive selection on introgressed allelic variants, typically involving a long-term ...
Jay F. Storz, Anthony V. Signore
openaire   +3 more sources

Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia

Frontiers in Pharmacology, 2022
Hypoxia, an essential feature of high-altitude environments, has a significant effect on drug metabolism. The hypoxia–gut microbiota–CYP450/drug transporter axis is emerging as a vital factor in drug metabolism.
Xue Bai, Xue Bai, Jianxin Yang, Guiqin Liu, Junbo Zhu, Qian Wang, Wenqi Gu, Linli La, Xiangyang Li, Xiangyang Li   +9 more
doaj   +1 more source

Metabolomic analysis of human plasma sample after exposed to high altitude and return to sea level.

PLoS ONE, 2023
When ascending to high altitude, it is a rigorous challenge to people who living in the low altitude area to acclimatize to hypoxic environment. Hypoxia exposure can cause dramatic disturbances of metabolism.
Jiayue Gao, Ming Zhao, Xiang Cheng, Xiangpei Yue, Fangbin Hao, Hui Wang, Lian Duan, Cong Han, Lingling Zhu   +8 more
doaj   +2 more sources

Orexin A protects against cerebral ischemia-reperfusion injury by enhancing reperfusion in ischemic cortex via HIF-1α-ET-1/eNOS pathway

Brain Research Bulletin
The purpose of this study was to investigate the protective effect and underlying mechanism of orexin A on cerebral ischemia-reperfusion injury, specifically through vasodilation mediated by the hypoxia inducible factor-1α (HIF-1α)-Endothelin-1(ET-1 ...
Minxia Zhu, Xiaofeng Li, Jing Guo, Zhaojun Zhang, Xu Guo, Zhuoqi Li, Junwei Lin, Pengfei Li, Zixuan Jiang, Yifan Zhu   +9 more
doaj   +1 more source

Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. [PDF]

, 2014
Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).
Huang, Lan, Jin, Jun, Li, Huijie, Qin, Jun, Zhang, Enhao, Zhang, Jihang   +5 more
core   +3 more sources

Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules

Cancer Biology & Therapy
Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against gastric cancer. To analyze the changes of microRNA (miRNA)
Xiaoping Wang, Zhendong Zhang, Xiaolan Cao   +2 more
doaj   +1 more source

Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response

Immunobiology
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI).
Minxia Zhu, Yaqi Lei, Zhaojun Zhang, Xu Guo, Jing Guo, Ruipeng Wu, Xiaofeng Li, Shibo Tian, Yuanhao Zhao   +8 more
doaj   +1 more source

Respiratory parameters at varied altitudes in intermittent mining work [PDF]

, 2017
Objectives: Workers in the mining industry in altitude are subjected to several risk factors, e.g., airborne silica and low barometric pressure. The aim of this study has been to assess the risks for this work category, evaluating single risk factors as ...
Bacaloni, Alessandro, Insogna, Susanna, Sinibaldi, Federica, Steffanina, Alessia, Zamora Saà, Margarita Cecilia   +4 more
core   +2 more sources

IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis

Autoimmunity
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.Objective This study aims to explore the association between IL-4 ...
Xiaoli Liu, Huqiang Mai, Liang Wang, Hengxun Zhang, Xuemei Li, Xuguang Li, Li Wang   +6 more
doaj   +1 more source

Mechanisms of Hemoglobin Adaptation to High Altitude Hypoxia [PDF]

High Altitude Medicine & Biology, 2008
Evidence from a number of vertebrate taxa suggests that modifications of hemoglobin (Hb) function may often play a key role in mediating an adaptive response to high altitude hypoxia. The respiratory functions of Hb are a product of the protein's intrinsic O(2)-binding affinity and its interactions with allosteric effectors such as protons, chloride ...
Storz, Jay F., Moriyama, Hideaki
openaire   +2 more sources