Results 21 to 30 of about 34,730 (280)

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women. [PDF]

, 2020
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations.
Anza-Ramirez, Cecilia, Corante, Noemi, DeYoung, Pamela N, Djokic, Matea A, Gaio, Eduardo, Gilbertson, Dillon, Heinrich, Erica C, Macarlupu, Jose L, Malhotra, Atul, Orr, Jeremy E, Powell, Frank L, Simonson, Tatum S, Villafuerte, Francisco C, Vizcardo-Galindo, Gustavo   +13 more
core   +1 more source

Pharmacokinetics of Acetaminophen and Metformin Hydrochloride in Rats After Exposure to Simulated High Altitude Hypoxia

Frontiers in Pharmacology, 2021
The pharmacokinetic characteristics of drugs were altered under high altitude hypoxia, thereby affecting the absorption, distribution, metabolism, and excretion of drug. However, there are few literatures on the pharmacokinetic changes of antipyretic and
Jun-bo Zhu, Jun-bo Zhu, Jian-xin Yang, Jian-xin Yang, Yong-qiong Nian, Gui-qin Liu, Ya-bin Duan, Xue Bai, Qian Wang, Yang Zhou, Xue-jun Wang, Ning Qu, Xiang-yang Li   +12 more
doaj   +1 more source

Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. [PDF]

, 2019
Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain
Anza-Ramirez, Cecilia, Bosompra, Naa-Oye, DeYoung, Pamela N, Djokic, Matea A, Gilbertson, Dillon, Heinrich, Erica C, Malhotra, Atul, Orr, Jeremy E, Powell, Frank L, Simonson, Tatum S, Wu, Lu   +10 more
core   +2 more sources

Resveratrol Ameliorates High Altitude Hypoxia-Induced Osteoporosis by Suppressing the ROS/HIF Signaling Pathway

Molecules, 2022
Hypoxia at high-altitude leads to osteoporosis. Resveratrol (RES), as an antioxidant, has been reported to promote osteoblastogenesis and suppress osteoclastogenesis.
Changqing Yan, Zirou Wang, Weili Liu, Lingling Pu, Ran Li, Chongyi Ai, Hongbao Xu, Baoyi Zhang, Tianhui Wang, Xiangyu Zhang, Zhaoli Chen, Xinxing Wang   +11 more
doaj   +1 more source

Design and conduct of Xtreme Everest 2: an observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia [PDF]

, 2015
Objective: oxygen availability falls with ascent to altitude and also as a consequence of critical illness. Because cellular sequelae and adaptive processes may be shared in both circumstances, high altitude exposure (‘physiological hypoxia’) assists in ...
Adams, Thomas, Feelisch, Martin, Gilbert-Kawai, Edward, Gilbert-Kawai, Grace, Grocott, Michael, Kumar, Rajendra, Levett, Denny, Martin, Daniel, Mitchell, Kay, Montgomery, Hugh, Murray, Andrew, Mythen, Michael, Peters, Mark, Sheperdigian, Adam   +13 more
core   +3 more sources

High-altitude hypoxia and preeclampsia [PDF]

Frontiers in Bioscience, 2007
The influence of hypoxia (lowered arterial blood and/or tissue PO2) on fetoplacental development and the role of hypoxia in preeclampsia are major research foci in perinatal biology. While animal and cell models are of utility, we do not know whether artificial hypoxic stimuli mimic the pathological conditions attributed to hypoxic stress in vivo; we ...
openaire   +2 more sources

Hypoxic regulation of ion channel function and expression [PDF]

, 2002
Acute hypoxia regulates the activity of specific ion channels in a rapid and reversible manner. Such effects underlie appropriate cellular responses to hypoxia which are designed to initiate cardiorespiratory reflexes and contribute importantly to other ...
Peers, C.
core   +1 more source

Altitude and COVID‐19: Friend or foe? A narrative review

Physiological Reports, 2021
Recent reports suggest that high‐altitude residence may be beneficial in the novel coronavirus disease (COVID‐19) implicating that traveling to high places or using hypoxic conditioning thus could be favorable as well.
Grégoire P. Millet, Tadej Debevec, Franck Brocherie, Martin Burtscher, Johannes Burtscher   +4 more
doaj   +1 more source

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]

, 2013
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
Begley, J, Boos, C, Hooper, T, King, R, Mellor, A, O'Hara, J, Piper, R, Smith, C, Stacey, M, Turner, S, Woods, DR, Yarker, J   +11 more
core   +2 more sources

Identification of key pathways, genes and immune cell infiltration in hypoxia of high-altitude acclimatization via meta-analysis and integrated bioinformatics analysis

Frontiers in Genetics, 2023
Background: For individuals acutely exposed to high-altitude regions, environmental hypobaric hypoxia induces several physiological or pathological responses, especially immune dysfunction.
Qiong Li, Qiong Li, Zhichao Xu, Zhichao Xu, Fujin Fang, Fujin Fang, Yan Shen, Yan Shen, Huan Lei, Huan Lei, Xiaobing Shen, Xiaobing Shen   +11 more
doaj   +1 more source