Pharmaceuticals, 2022 (1) Background: High-altitude hypoxia has been shown to affect the pharmacokinetic properties of drugs. Although there is a high incidence of cardiovascular disease among individuals living in high-altitude areas, studies on the effect of high-altitude ...
朱俊博, Delong Duo, Xue Bai
exaly +3 more sources
High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal HIF2a/Iron-Metabolism Pathway [PDF]
Biomedicines, 2023 Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE.
Sisi Zhou, Jun Yan, Kang Song, Ri-Li Ge
doaj +2 more sources
Physiological Genomics of Adaptation to High-Altitude Hypoxia
Annual Review of Animal Biosciences, 2021 Population genomic studies of humans and other animals at high altitude have generated many hypotheses about the genes and pathways that may have contributed to hypoxia adaptation. Future advances require experimental tests of such hypotheses to identify causal mechanisms.
Jay F Storz
exaly +4 more sources
The gut–kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor [PDF]
Annals of MedicineBackground The high-altitude plateau environment, defined by hypobaric hypoxia, poses considerable health risks to human populations. Due to their substantial oxygen requirements, the kidneys are particularly susceptible, as are the intestines, with ...
Peiwen Wu +6 more
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High-altitude hypoxia exacerbates chemotherapy-induced myelosuppression by lowering serum G-CSF/GM-CSF and regulating apoptosis and proliferation [PDF]
Discover OncologyThe unique hypoxic environment in high-altitude regions is increasingly drawing attention for its impact on the health of residents, particularly in patients post-chemotherapy.
Jing Shi +6 more
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High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis [PDF]
Cell Death DiscoveryTraumatic brain injury (TBI) is one of the leading causes of disability and mortality, which was classified as low-altitude TBI and high-altitude TBI. A large amount of literature shows that high-altitude TBI is associated with more severe neurological ...
Peng Zou +13 more
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Controlled Ascent Rate Enhances Autophagy and Mitigates Acute Lung Injury in Rats Exposed to High‐Altitude Hypoxia by Inhibiting Oxidative Stress and Inflammation [PDF]
Global ChallengesThe gradual ascent strategy, an effective measure to prevent acute mountain sickness by enabling the body to adapt to high–altitude hypoxia, has an unclear mechanism.
Kairui Huang +4 more
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Novel mechanisms of intestinal flora regulation in high-altitude hypoxia [PDF]
HeliyonBackground: This study investigates the molecular mechanisms behind firmicutes-mediated macrophage (Mψ) polarization and glycolytic metabolic reprogramming through HIF-1α in response to intrinsic mucosal barrier injury induced by high-altitude hypoxia ...
Fang Yan +4 more
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Research progress of orexin on the regulation of cardiovascular activities [PDF]
Jichu yixue yu linchuang, 2023 Orexin(OX) is a neuropeptide mainly released by the hypothalamus. In the central nervous system, orexin neurons form extensive connections with other neuronal nuclei and participate in energy metabolism, sleep cycle and cardiovascular activity regulation.
ZHU Minxia
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Hypoxia Conditioning for High-Altitude Pre-acclimatization [PDF]
Journal of Science in Sport and Exercise, 2022 Abstract Purpose Main purposes of pre-acclimatization by hypoxia conditioning (HC) are the prevention of high-altitude illnesses and maintenance of aerobic exercise performance. However, robust evidence for those effects or evidence-based guidelines for exposure strategies, including recommendations to ensure safety, are
Martin Burtscher +2 more
openaire +2 more sources