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High-Density Lipoprotein Infusions
Cardiology Clinics, 2018High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL.
Kohei, Takata +2 more
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High density lipoprotein structure
Frontiers in Bioscience, 2003HDL particles possess important antiatherogenic functionalities and understanding of the molecular mechanisms underlying these effects requires detailed knowledge of HDL structure. This review summarizes current understanding of HDL structure. The various HDL subclasses are compared in terms of their lipid and protein compositions.
Sissel, Lund-Katz +3 more
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High-Density Lipoprotein Metabolism
1980Publisher Summary Cholesterol is an essential structural component of all cell membranes. The cholesterol of extrahepatic tissues appears to be derived from receptor-mediated uptake of plasma low-density lipoprotein, to a lesser extent from endogenous synthesis, and also from direct transfer from cholesterol-rich lipoproteins. Most tissues are unable
A, Nicoll, N E, Miller, B, Lewis
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High-density lipoprotein subclasses
Current Opinion in Lipidology, 1994This review describes recent advances that have been made in the separation of HDL subfractions by physicochemical and immunological methods and the relationship between the particles obtained by the different procedures. The metabolic interconversions that occur as a result of cholesteryl ester transfer protein (CETP), lecithin:cholesterol ...
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High-density lipoprotein turnover
American Heart Journal, 1987High-density lipoprotein (HDL) metabolism has been reviewed from information derived from turnover studies in humans. The two major HDL apoproteins AI and AII have different removal rates, reflecting the faster catabolism of HDL2 than of HDL3. This is caused by the continual cycle of formation of HDL2 from HDL3 and its reversion to HDL3, in response to
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High-Density Lipoprotein Mimetics: Focus on Synthetic High-Density Lipoprotein
The American Journal of Cardiology, 2007Epidemiologic studies show an inverse relation between high-density lipoprotein (HDL) cholesterol levels and coronary artery disease, and proof-of-concept experimental studies suggest that HDL and its apolipoproteins, specifically apolipoprotein (apo) A-I , have atheroprotective effects.
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High density lipoprotein and lipoprotein oxidation
Current Opinion in Lipidology, 1996HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules.
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Quantitation of high density lipoproteins
Lipids, 1978AbstractThe demand for high density lipoprotein (HDL) quantitation has dramatically increased with the renewed awareness of the importance of HDL as a negative risk factor for coronary heart disease. HDL is usually estimated by specific precipitation of the non‐HDL apoB‐containing lipoproteins by polyanions and divalent cations followed by measurement ...
J J, Albers, G R, Warnick, M C, Chenng
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2007
Low plasma levels of cholesterol carried by high-density lipoprotein (HDL) particles are firmly established as a major cardiovascular risk factor. Paradoxically, cardiovascular mortality is also elevated at extremely high levels of HDL cholesterol. Furthermore, genetic epidemiology often does not support a causal relationship between HDL cholesterol ...
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Low plasma levels of cholesterol carried by high-density lipoprotein (HDL) particles are firmly established as a major cardiovascular risk factor. Paradoxically, cardiovascular mortality is also elevated at extremely high levels of HDL cholesterol. Furthermore, genetic epidemiology often does not support a causal relationship between HDL cholesterol ...
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Alcohol: High Density Lipoproteins, Apolipoproteins
Alcoholism: Clinical and Experimental Research, 1986Plasma lipids, including high density lipoproteins (HDL) components, were studied tn 26 healthy male alcohol abusers. Age‐ and gender‐matched controls denied the use of substances or behaviors associated with increased HDL. On admission to abstinence treatment, the alcohol abusers' total cholesterol and triglycerides were usualy normal.
P, Cushman, J, Barboriak, J, Kalbfleisch
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