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High-Density Lipoprotein Infusions
Cardiology Clinics, 2018High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL.
Kohei Takata +2 more
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Plasma High-Density Lipoproteins
New England Journal of Medicine, 1978WHY all the recent excitement about highdensity lipoproteins (HDL)? Because of the strong inverse relation between plasma levels of HDL and mortality from cardiovascular disease.1,2 Increased serum...
Donald Small, Alan R. Tall
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Genetics of high-density lipoproteins [PDF]
Current Opinion in Cardiology, 2006 High-density lipoproteins have multi-factorial anti-atherosclerosis properties: they have potent anti-oxidant effects and prevent the oxidation of low-density lipoproteins; they have anti-inflammatory effects; they modulate vascular endothelial cell function and transport cholesterol back to the liver for excretion into the bile - a process called ...
Zari Dastani +3 more
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High density lipoprotein and lipoprotein oxidation
Current Opinion in Lipidology, 1996HDL protects LDL from oxidative damage known to contribute to the onset and progression of atherosclerosis. This antioxidant protection by HDL is mediated by intrinsic hydrolytic enzyme systems, by accelerated selective uptake of lipid peroxides from HDL and by antioxidant molecules.
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High-Density Lipoprotein Mimetics: Focus on Synthetic High-Density Lipoprotein
The American Journal of Cardiology, 2007Epidemiologic studies show an inverse relation between high-density lipoprotein (HDL) cholesterol levels and coronary artery disease, and proof-of-concept experimental studies suggest that HDL and its apolipoproteins, specifically apolipoprotein (apo) A-I , have atheroprotective effects.
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High density lipoprotein structure
Frontiers in Bioscience, 2003HDL particles possess important antiatherogenic functionalities and understanding of the molecular mechanisms underlying these effects requires detailed knowledge of HDL structure. This review summarizes current understanding of HDL structure. The various HDL subclasses are compared in terms of their lipid and protein compositions.
Stephen T. Thuahnai +3 more
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High-density lipoprotein--the clinical implications of recent studies.
New England Journal of Medicine, 1989DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in athero...
D. Gordon, B. Rifkind
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High density lipoprotein in octogenarians
Biochemical Medicine, 1983High density lipoprotein (HDL) cholesterol, total cholesterol, and total triglyceride levels were assayed in the plasma of 42 octogenarians. No differences were found in the levels of HDL cholesterol and total triglycerides when comparing subjects with and without ischemic heart disease.
J.Gerald Brook +2 more
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High-density lipoprotein turnover
American Heart Journal, 1987High-density lipoprotein (HDL) metabolism has been reviewed from information derived from turnover studies in humans. The two major HDL apoproteins AI and AII have different removal rates, reflecting the faster catabolism of HDL2 than of HDL3. This is caused by the continual cycle of formation of HDL2 from HDL3 and its reversion to HDL3, in response to
Paul J. Nestel, Paul J. Nestel
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Diet and high density lipoproteins
Lipids, 1981AbstractThe acute and subacute effects of different diets on serum high density lipoprotein (HDL) cholesterol concentration and/or HDL composition are described. In obese normolipemic, hypercholesterolemic (type II) and hypertriglyceridemic (type IV) patients, low HDL cholesterol values remained low during total starvation for 2 weeks. Prudent diets in
Peter Oster +5 more
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