Results 61 to 70 of about 1,615,031 (256)

High-density lipoproteins during sepsis: from bench to bedside

Critical Care, 2020
High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver conferring them a cardioprotective ...
Sébastien Tanaka, D. Couret, Alexy Tran-Dinh, J. Duranteau, P. Montravers, A. Schwendeman, O. Meilhac   +6 more
semanticscholar   +1 more source

LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans

Journal of Lipid Research, 2015
The mechanisms by which LDLs and HDLs cross the vascular endothelium from plasma into interstitial fluid are not understood, and have never been studied in humans in vivo.
C. Charles Michel, M. Nazeem Nanjee, Waldemar L. Olszewski, Norman E. Miller   +3 more
doaj  

Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.

Journal of Clinical Investigation, 1998
HDL levels are inversely related to the risk of developing atherosclerosis. In serum, paraoxonase (PON) is associated with HDL, and was shown to inhibit LDL oxidation.
M. Aviram, M. Rosenblat, C. Bisgaier, R. Newton, S. Primo-Parmo, B. Du   +5 more
semanticscholar   +1 more source

Prevention of low density lipoprotein aggregation by high density lipoprotein or apolipoprotein A-I.

Journal of Lipid Research, 1990
We have shown previously that low density lipoprotein (LDL) subjected to vortexing forms self-aggregates that are avidly phagocytosed by macrophages. That phagocytic uptake is mediated by the LDL receptor.
JC Khoo, E Miller, P McLoughlin, D Steinberg   +3 more
doaj  

Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution

Journal of Lipid Research, 2002
Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and ...
Susan J. Murdoch, Molly C. Carr, Hal Kennedy, John D. Brunzell, John J. Albers   +4 more
doaj  

High density lipoprotein mediates anti-inflammatory transcriptional reprogramming of macrophages via the transcriptional repressor ATF3

Nature Immunology, 2013
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases.
D. De Nardo, L. Labzin, H. Kono, R. Seki, S. Schmidt, M. Beyer, Dakang Xu, S. Zimmer, Catharina Lahrmann, F. Schildberg, J. Vogelhuber, Michael Kraut, T. Ulas, A. Kerksiek, Wolfgang Krebs, Niklas Bode, A. Grebe, M. Fitzgerald, N. J. Hernandez, Bryan R. G. Williams, P. Knolle, M. Kneilling, M. Röcken, D. Lütjohann, S. Wright, J. Schultze, E. Latz   +26 more
semanticscholar   +1 more source

High Density Lipoproteins: Metabolism, Function, and Therapeutic Potential

Frontiers in Cardiovascular Medicine, 2020
High Density Lipoproteins (HDLs) have long been considered as “good cholesterol,” beneficial to the whole body and, in particular, to cardio-vascular health.
A. Jomard, E. Osto
semanticscholar   +1 more source

Apolipoprotein M expression increases the size of nascent preβ HDL formed by ATP binding cassette transporter A1

Journal of Lipid Research, 2010
Apolipoprotein M (apoM) is a novel apolipoprotein that is reportedly necessary for preβ HDL formation; however, its detailed function remains unknown. We investigated the biogenesis and properties of apoM and its effects on the initial steps of nascent ...
Anny Mulya, Jeongmin Seo, Amanda L. Brown, Abraham K. Gebre, Elena Boudyguina, Gregory S. Shelness, John S. Parks   +6 more
doaj  

Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein.

Journal of Clinical Investigation, 1995
Our group has previously demonstrated that oxidized phospholipids in mildly oxidized LDL (MM-LDL) produced by oxidation with lipoxygenase, iron, or cocultures of artery wall cells increase monocyte-endothelial interactions and this sequence of events is ...
Andrew, D. Watson, Judith, A. Berliner, Susan, Y. Hama, Bert, N. La, Du, Kym, F., Faull, Alan, M. Fogelman, Mohamad, Navabt   +15 more
semanticscholar   +1 more source

High-density lipoprotein cholesterol, coronary artery disease, and cardiovascular mortality.

European Heart Journal, 2013
AIMS High-density lipoprotein (HDL) cholesterol is a strong predictor of cardiovascular mortality. This work aimed to investigate whether the presence of coronary artery disease (CAD) impacts on its predictive value. METHODS AND RESULTS We studied 3141
G. Silbernagel, B. Schöttker, S. Appelbaum, H. Scharnagl, M. Kleber, T. Grammer, A. Ritsch, U. Mons, B. Holleczek, G. Goliasch, A. Niessner, B. Boehm, R. Schnabel, H. Brenner, S. Blankenberg, U. Landmesser, W. März   +16 more
semanticscholar   +1 more source