Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Signpost Testing to Navigate the Parameter Space of the Gaussian Graphical Model With High-Dimensional Data. [PDF]
Biom JRuan K +2 more
europepmc +1 more source
Classification of high dimensional data: High Dimensional Discriminant Analysis
, 2005 We propose a new method of discriminant analysis, called High Dimensional Discriminant Analysis (HHDA). Our approach is based on the assumption that high dimensional data live in dierent subspaces with low dimensionality. Thus, HDDA reduces the dimension for each class independently and regularizes class conditional covariance matrices in order to ...
Bouveyron, Charles +2 more
openaire +1 more source
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Asymmetric canonical correlation analysis of Riemannian and high-dimensional data. [PDF]
Electron J StatBuenfil J, Lila E.
europepmc +1 more source
An Ensemble Outlier Detection Method Based on Information Entropy-Weighted Subspaces for High-Dimensional Data. [PDF]
Entropy (Basel), 2023 Li Z, Zhang L.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown +6 more
wiley +1 more source
Multi-Platform Multivariate Regression with Group Sparsity for High-Dimensional Data Integration. [PDF]
Entropy (Basel)Qin S, Zhang G, Gao X, Wu Y.
europepmc +1 more source
Knockoff procedure for false discovery rate control in high-dimensional data streams. [PDF]
J Appl Stat, 2023 Wai Tsang K, Tsung F, Xu Z.
europepmc +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source